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Biomedical subjects

P Pras

Publications and source records attributed to P Pras.

At least 19 recordsLinked to original sources
PubMed2001

[Long-term treatment of Alzheimer's disease: followup of a cohort of 255 patients treated with lacrine for four years].

We describe the follow-up of a cohort of 255 Alzheimer's disease (AD) patients (81 males, 174 females) treated by tacrine during 4 years. We performed the survey of hepatic, cholinergic and general tolérance. Drug efficacy was measured by MMS examination on weeks 0, 18, 30, 52, 104, 156 and 208. A total of 190 patients (74.5 percent) were dropped out of this study, 75 (29 percent) for adverse events. We found 85 hepatic (33 percent), 79 cholinergic (31 percent), 31 (12 percent) neuropsychiatric and 72 general (28 percent) side effects. In term of drug efficacy we observed a global decline of 2.5 MMS points during the first year and 2 MMS points between W52 and W156. Tacrine's symptomatic efficacy, defined as the number of patients improved or stabilized at W30, was present in 50 patients (46 percent) among the 109 patients reaching W30. The intensity of symptomatic efficacy was expressed by a 2.7 MMS points increase in 37 patients improved on W30. The long term effects of Tacrine, measured by the MMS score at one year, showed a positive impact as the MMS was 2.5 points above the expected score in non treated AD patients. This study raises the practical problem of optimal cholinesterase inhibitors use in AD and the theoretical question of long term action of cholinesterase inhibitors on cerebral lesions of AD.

Aged↗
PubMed1985

[Exercise test in patients over 70 years of age].

One hundred and sixty-four out of 171 prescribed tests were carried out (96 p. 100) in 48 women aged 70 to 85 years (mean 74,3 years), and 116 men aged 70 to 84 years (mean 73,4 years). The indications were: coronary artery disease (113 cases), cardiac arrhythmias (44 cases), cardiac failure (12 cases), hypertension (9 cases) and assessment of apparently normal subjects (7 cases). The tests were performed on a bicycle ergometer in the upright position; the work load was increased stepwise every 3 minutes with automatic electrocardiographic recording. 37.2 p. 100 of subjects exceeded 90 p. 100 of the maximal predicted heart rate for age; 23.2 p. 100 failed to achieve 75 p. 100 of the target heart rate. There were no serious complications but 4.2 p. 100 minor incidents occurred. The mean maximum work load was 66,5 watts (71.9 W for men and 53.5 W for women). These results show that exercise testing is possible in geriatric patients and provides information of comparable value to that obtained in younger patients. The investigation is safe when performed under strict medical supervision.

Aged↗
PubMed1984

[Hypochromic anemia and small bowel diverticula].

The authors appreciate the possible responsibility of small intestine diverticulosis in three patients with iron deficiency anemia. In the first case, anemia was associated with colo-duodenal fistula. In the second and third cases, because of the negativity of gastric and large bowel investigations, a barium opacification was done, which showed diverticulosis. This was considered as probably responsible for the anemia. After a review of the literature, the authors conclude that small intestine diverticulosis may lead to iron deficiency anemia through chronic blood loss.

Aged↗
PubMed1983

[The effect of various diseases on the zinc plasma level].

Zinc, an important enzymatic cofactor, takes part in numerous metabolic pathways. In man, zinc deficiencies may be due either to deficient absorption or to excessive use. In this study in 285 patients hospitalized in a department of internal medicine for acute or chronic conditions, serum zinc assays have shown the following results: serum zinc concentrations are significantly decreased in acute critical conditions (cardiovascular ischemic disorders, heart failure, infections); in chronic conditions, serum zinc is decreased in some instances (renal failure, cancer, alcoholism, diarrhea), while it remains normal in others (compensated heart failure, non-insulin dependent diabetes, arterial hypertension, obesity). The fall in serum zinc concentrations is usually correlated with the severity of the clinical condition.

Acute Disease↗
PubMed1981

[Clinical value of the determination of serum digoxin levels (author's transl)].

The authors refer to the technique of the serum digoxin enzyme immunoassay, and they report the results of 297 dosages concerning 111 hospitalized patients. The normal plasmatic rates are of 1,4 +/- 0,6 microgram/l in patients who present no sign of digitalic overdosage. The rates are of 5,2 +/- 1,6 microgram/l in cases of intoxication. The difference between these rates is greatly significant (p less than 0.001). The limit between therapeutic and toxic rates is situated around 3 microgram/l with an overlapping from 2 to 3 microgram/l. Authors then examine the individual factors that intervene in digoxin metabolism and especially study the influence of age, myocardic factors and renal insufficiency. On the basis of these results and review of the literature, they emphasize the interest of serum digoxin determination in the diagnosis of digitalis toxicity, as well as in the management of high risk patients, and of cardiopathies difficult to stabilize.

Aged↗
PubMed1979

[A case of idiopathic disseminated pulmonary ossification (author's transl)].

A patient aged 92 years was discovered to have disseminated pulmonary ossification of the interstitial tissues without any valvular cardiopathy. The authors underline the rarety of such ectopic ossifications and review their radiological, anatomical, and etiological characteristics as reported in the published literature.

Adult↗
PubMed1979

[Pulmonary mycobacteriosis due to Mycobacterium chelonei: a report on a new case (authors' transl)].

Mycobacterium chelonei is a saprophytic germ usually devoid of pathogenic activity. Over a period of about the last ten years, however, several cases have been reported, including twelve cases of bronchopulmonary affections, in which it has been the infecting organism. The radiographic appearance is in every respect similar to that observed in pulmonary tuberculosis. A positive diagnosis of infection due to this germ can be made by the absence of Kuch's bacillus the lack of therapeutic effect of antituberculous medication, a positive skin reaction to specific antigens, and positive Mycobacterium Chelonei cultures from biopsy specimens. A new case of this infection is reported.

Humans↗
PubMed1977

[Radioclinical aspects of tibio-tibial diaphyseal toxo-pachyosteosis. Weismann-Netter and Stuhl disease. Two new cases (author's transl)].

The authors report two cases of individuals sufferring from bow-leggedness, which they attribute to tibio-fibular thoxo-pachyosteosis. On the basis of these new cases, they review the radioclinical characteristics of the diagnosis of Weismann-Netter and Stuhl tibio-fibular toxo-pachy-osteosis. This dysmorphic syndrome is usually familial, very likely of genetic origin, and characterised by the small stature of those affected with curving of the tibia and fibula with an anterior convexity and thickening of the posterior cortex of the bony diaphysis. This clinical and radiological individuality permits its differential diagnosis from rickets and congenital syphilis, with which it was long confused. This dysmorphy causes no problems and therefore requires no general treatment.

Aged↗