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P Prevost

Publications and source records attributed to P Prevost.

29 records · Page 2Linked to original sources
PubMed1988

Multiple drug combinations with "low-dose" cyclosporin for renal transplantation. Multivariate analysis of risk factors determining short-term graft survival within one renal transplant center.

The factors affecting graft survival in transplant recipients receiving cyclosporin (CsA) are still being debated. Our report is based on an analysis of 202 successive transplantations performed in our institution from May 1984 to December 1986, using low-dose CsA as the basic means of immunosuppression. A total of 142 patients received the triple combination CsA, azathioprine (AZA), and corticosteroids. Sixty patients received a prophylactic combination of CsA, corticosteroids, and antilymphocyte globulins (ALG). From January to December 1986, both regimens were compared in a prospective randomized trial. The factors that affect graft survival were analyzed using the Cox multivariate hazard analysis. The relative risks were calculated for pretransplant baseline risk factors and for outcome-dependent post-transplant risk factors for surviving grafts at 1 month. Transplants performed with a prolonged ischemia time and patients whose graft did not function immediately were statistically at higher risk of graft loss. Adding prophylactic ALG to CsA was associated with better graft survival. Patients who experienced more than 1 rejection crisis and patients whose 1-month CsA dose was lower than or equal to 5 mg/kg per day were also at significantly higher risk of further graft loss. Neither HLA matching, peak panel reactivity, age of the recipient, occurrence of post-transplant renal dysfunction nor 1-month renal function affected the short-term graft outcome.

Adrenal Cortex Hormones↗
PubMed1984

Genetic polymorphism of the fourth component of complement and type 1 (insulin-dependent) diabetes.

The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in propositi than in non-affected siblings (40 out of 74 versus 36 out of 92, p less than 0.05). When comparing the distribution of the phenotype C4BQ0 in Type 1 diabetic patients and normal control subjects, the difference was significant in patients bearing DR3 or DR4 (56% and 25%, respectively, p less than 0.003). The main linkage disequilibria were observed among the 74 propositi: B18, BfF1, C4, A3, BQ0, DR3; B12, BfS, C4, A3, BQ0, DR4. The existence of a silent allele at the C4 B locus is known to be associated with a defective immune response.

Complement C4↗
PubMed1984

Distribution of HLA-A,B alleles in 13 panels of blood donors in France.

In this study, we analysed 13 samples of the French population--4147 non-related individuals living in Bordeaux, Brest, Caen, Dijon, Limoges, Lyon, Marseille, Nancy, Paris, Poitiers, Rennes, Strasbourg and Toulouse--all of whom were typed for 10 alleles of the HLA-A locus and 16 alleles of the HLA-B locus. The results showed a strong heterogeneity (chi 2 = 675.13 for 324 df, p less than 10(5)). A diagram has been drawn up, showing the matrix of genetic distances obtained thanks to the B2 of Balkrishnan & Sanghvi (1968). This diagram enables us to envisage the hypothesis of 6 homogeneous clusters. A partition of chi 2 was used to test this 6 luster hypothesis: Paris and Caen (p = 0.98); Nancy, Strasbourg (p less than 5%); Rennes, Brest (p less than 1%); Dijon, Lyon, Marseille (p = 0.89); Limoges, Poitiers (p = 0.18); Toulouse, Bordeaux (p less than 10(-5)). The heterogeneity within these clusters represents only 1/43 of the total heterogeneity.

Alleles↗
PubMed1981

[Prethoracic aesophagoplasty in incurable stenosis of aesophagus (author's transl)].

The dermato-oesophagoplasty had its hour of glory. The complexity of the dermato-oesophagoplasty has made it totally abandoned and it presents only a historic advantage today. However, the unexpected arrival after 45 years of a canceration of cutaneous duct like that was observed on the second case of dermato-oesophagoplasty published in France comes to solve some problems of pathogeny of a surgical technic that the authors analyse in the light of more recent labours on the oesophagoplasty.

Adolescent↗
PubMed1980

[Peritoneal hemorrhage following spontaneous rupture of a liver containing a hepatoma (author's transl)].

Two cases of a rare complication of this tumor have been reported. A hepatoma can provoke an intra-peritoneal hemorrhage in two different ways: either by tearing through the hepatic tissue which surrounds it or by necrosis and hemorrhage of the tumor itself. This complication may be the initial symptom and may require emergency surgery. Local hemostasis if often precarious and does not resolve the underlying oncological problem. At best, survival is limited to several months. Rapid removal of the tumor seems to be the only means of prolonging survival although there is not yet much data on this in the literature. At any rate the poor general condition of the patient, the frequent multiplicity of the tumoral locations and the habitual cirrhotic nature of the rest of the liver would rule out any possible surgical removal in 90% of cases. In the remaining 10% where surgery is possible, the average survival rate is 13 months.

Aged↗