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Biomedical subjects

P R Gupta

Publications and source records attributed to P R Gupta.

At least 19 recordsLinked to original sources
PubMed2002

Shah Waardenberg syndrome.

Intermittent or partial small bowel obstruction in a neonate may be a rare presentation of total aganglionosis. The presence of partial albinism and white forelock should alert the clinician to the possibility of associated Hirschsprung disease as a cause of bowel symptoms. Such a rare association has been called Shah Waardenberg syndrome and is being reported.

Diagnosis, Differential↗
PubMed1997

Evaluation of oral dipyridamole electrocardiography test in ischaemic heart disease.

Forty-three cases of ischaemic heart disease of the age group 35-72 yrs with positive treadmill test (TMT) results were administered dipyridamole in the morning on empty stomach. Heart rate, BP and ECG were recorded before and every 15 mins after oral dipyridamole upto 2 hrs. ECG was repeated every 5 mins when patients developed angina or ischaemic ECG changes. Oral dipyridamole electrocardiography test (ODET) was found to be positive in 21 (48.83%) cases and majority of them developed ST depression in 25-40 mins and persisted for less than 30 mins. While compared with TMT results patients having chest pain, lower target heart rate (< 75%), shorter time to onset (< 2 mins) of ST depression and longer duration (> 8 mins) of ST depression had significantly higher rates of positivity on ODET than those without these manifestations. There were minor changes in hemodynamic parameter (heart rate, systolic and diastolic blood pressure) and other minor side effects encountered include mild headache and benign unifocal VPCs. Oral dipyridamole is viewed as a safe drug and may be used as a substitute for TMT specially in economically poor and physically disabled patients with significant coronary artery disease.

Administration, Oral↗
PubMed1993

Prevalence of initial drug resistance in tuberculosis patients attending a chest hospital.

Sputum samples from pulmonary tuberculosis patients attending a hospital for chest diseases and tuberculosis at Jaipur, India were directly subjected to sensitivity tests to detect drug resistance to streptomycin (S), isoniazid (I), rifampicin (R) and ethambutol (Emb) by slide culture technique. Drug resistance was observed to one or more drug in 19.9 per cent of the patients. I resistant organisms were present in 10.1 per cent of patients, S resistance in 7.6 per cent, R resistance in 3.0 per cent and Emb resistance in 2.6 per cent. Resistance was limited to a single drug in 16.7 per cent patients. Drug resistance was unrelated to age and sex of the patients.

Adolescent↗
PubMed1992

Adverse effects of oral amiodarone therapy.

Oral amiodarone was administered to 38 patients (25 males, 13 females) with mean age of 43.6 years. Ventricular and supraventricular arrhythmias were present in 30 and 8 patients respectively. Amiodarone was given as 400-1200 mg/day for 1-2 weeks as loading dose and then it was maintained as 100-600 mg/day. The mean duration of therapy was 12.4 months. Adverse effects were noted in 21 (55.3%) cases. The commonest adverse effects observed were asymptomatic corneal microdeposits followed by gastrointestinal, cardiac, neurological and cutaneous disturbances. The drug was withdrawn in 2 (5.3%) patients because of nausea and vomiting. One patient died of pulmonary infiltrations. It is concluded that adverse effects are common with amiodarone but are tolerated well, making this drug an excellent choice for treatment of cardiac arrhythmias.

Administration, Oral↗
PubMed1992

Ranitidine--rifampicin interaction.

Newly diagnosed patients of pulmonary tuberculosis (n = 112) were put on a rifampicin-containing drug regimen. Fifty six patients were also given a placebo tablet twice daily while the other fifty-six were given ranitidine 150 mg twice daily. Gastric pH, gastric emptying time, serum rifampicin levels, urinary total and unchanged rifampicin, serum bilirubin and ALT levels were measured serially. Clinical record of adverse symptoms was maintained. Ranitidine increased the basal as well as post-drug gastric pH without altering the gastric emptying time. Concomitant administration of ranitidine and rifampicin did not alter the absorption, metabolism or excretion of the latter but reduced the frequency of gastrointestinal symptoms.

Adult↗
PubMed1992

Influence of prior information of drug toxicity on patient compliance.

Sixty patients with pulmonary tuberculosis, who had not received any chemotherapy in the past, were divided into two groups. All the patients were put on isoniazid, rifampicin and pyrazinamide for 8 weeks followed by isoniazid and rifampicin for another 18 weeks. Group A patients were informed of the likely occurrence of anorexia and/or vomiting but Group B patients were not. Routine and default retrieval home visits were given to ensure maximal drug compliance. Drug toxicity related early defaults were significantly less common in Group A patients (1 of 30) as compared to Group B (6 of 30).

Adult↗
PubMed1992

Tropical pyomyositis in India: a clinico-histopathological study.

Eighteen cases of tropical pyomyositis, aged 12-45 years, were seen over a 3-year period. There was clustering of cases in January, February and July to October. Male:female ratio was 14:4. Multiple muscular lesions (greater than 2) were common (67%). Extramuscular complications were present in 50% of the cases. Cardio-pulmonary involvement was most frequent. Muscle biopsies, done in 16 cases, showed suppurative changes (pus) in 15 cases and one case of non-suppurative myositis. Muscle necrosis, cellular infiltration with polymorphs and haemorrhage in-between muscle fibres were common.

Adolescent↗
PubMed1989

Cardiac changes in acute viral hepatitis in Varanasi (India): case reports.

Three cases of acute viral hepatitis are reported with various cardiac changes such as transient left ventricular hypertrophy, myocarditis and progressive cardiomegaly (cardiomyopathy). Extra-hepatic manifestations of acute viral hepatitis are rare but have been well documented. The aims of the present study are to highlight the cardiac involvement in acute viral hepatitis and to report the clinical implications of cardiac changes in acute viral hepatitis.

Acute Disease↗
PubMed1985

Tuberculous fistula of cheek. Report of a case.

A case of tuberculous fistula of the cheek is reported. The fistula was caused primarily by a carious tooth and was infected with tubercle bacilli present in the sputum of the patient, who had pulmonary tuberculosis.

Adult↗