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Biomedical subjects

P R Mann

Publications and source records attributed to P R Mann.

17 recordsLinked to original sources

Crossed-quadrant homonymous hemianopsia.

This case report illustrates the clinicopathological correlation between the anatomic defect of bilateral occipital lobe infarction with crossed-quadrant homonymous hemianopsia that resulted from a cervical spine injury. Routine ophthalmological and neuroradiological investigations were undertaken, including magnetic resonance imaging scanning, that demonstrate some important characteristics of this rare field defect.

Adult↗

Distribution of glycoproteins containing fucose in normal and psoriatic keratinocytes.

Electron microscope autoradiography has been used to compare the fucose-containing glycoproteins of normal and psoriatic epidermis. Normal keratinocytes and uninvolved psoriatic cells have most of their fucose on the plasma membrane, whereas involved psoriatic cells retain more within the cytoplasm. The fucose distribution in other epidermal cell types is also described.

Autoradiography↗

Induction of basal lamina formation in epidermal cell cultures in vitro.

Guinea-pig epidermal cells were grown on 2 types of rat collagen substrate. The cells showed the same sort of differentiation as occurs in cells growing on rigid plastic. In addition, basal lamina formed patchily at the interface with collagen. If the collagen was eroded away the basal lamina also disappeared.

Animals↗

An eosinophilotactic factor derived from rat mast cells.

Rat eosinophils have been showed to respond chemotactically to the supernatant from mast cells which have been disrupted by freezing and thawing and from mast cells which have been specifically degranulated by Compound 48/80 or by antigen challenge or sensitised cells. The fact that the chemotactic response is not dependent on allergic degranulation suggests that the chemotactic factor is present pre-formed in the mast cells rather than being generated in response to an antigen-antibody reaction.

Animals↗