PubMed Health⌕ Search

Biomedical subjects

P R Moret

Publications and source records attributed to P R Moret.

At least 19 recordsLinked to original sources

[Myocardial infarction in the adult under 35 years of age].

Infarction in the adult aged less than 35 is almost always accompanied by risk factors, the most common of which are tobacco abuse, lipid disturbances, obesity, a strong family history of cardiovascular disease and, in the woman, the use of contraceptives. The coronary arteries are sometimes normal (10-15 p. cent) but coronary lesions are most often single vessel, proximal and affect the anterior interventricular branch. Actual coronary thrombosis probably plays a more important role than in the older adult. Ventricular function is often markedly impaired. The infarct is most often anterior, transmural and large in size, with ventricular arrhythmias more frequent and a higher risk of sudden death. Post-hospital complications are the same as in the older adult, with possibly less good results of aorto-coronary venous bypasses. Long term mortality depends directly upon the number of vessels affected, but is markedly better than in the older adult.

Adult↗

[Physical training in high altitude].

Hemodynamic parameters and myocardial extraction of lactate and free fatty acids (FFA) have been studied at rest and during exercise (bicycle) in 9 mountain climbers who spent 4 weeks in the Himalayas at an altitude of 5500-7000 m. All investigations were performed before and immediately after the stay at high altitude. The combined effect of physical training and hypoxemia of high altitude did not alter the hemodynamic parameters, calculated VO2 max, production of lactate or decrease of FFA during the exercise test, but myocardial extraction of lactate and FFA changed. After returning from the expedition myocardial extraction (at rest and during exercise) of lactate increased and that of FFA decreased. The reasons for these alterations and their goals and implications are discussed.

Adult↗

[Benign acute pericarditis: choice of treatment?].

101 cases of acute benign pericarditis covering a period of 18 years are reported, and it is stressed that 80% of patients who relapsed had been treated with corticosteroids. It was also found that corticotherapy did not favourably influence the evolution of the tamponade risk, the persistence of cardiomegaly or pericardic constriction. It is concluded that, except for a few well-defined indications, corticotherapy is to be avoided in the treatment of acute benign pericarditis because of the high risk of recurrence. Some suggestions regarding the indications for corticotherapy are presented.

Adrenal Cortex Hormones↗

[Protective effect of pyridoxilate on the hypoxic myocardium. Experimental studies].

The protective action of piridoxilate on hypoxic myocardium has been studied on rats in acute hypoxia (isolated heart, perfused with a non-oxygenated solution) and in prolonged hypoxia (3 days at high [3454 m] altitude). Piridoxilate maintained a higher ATP level with a much lower production of lactate. The mechanisms of action of piridoxilate are probably fairly similar to those of Na dichloracetate.

Adenosine Triphosphate↗

[Effects of propranolol on pulmonary hypertension, right ventricular hypertrophy and metabolic myocardial changes due to acute hypoxemia due to high altitude].

In rats, a 3-day stay at an altitude of 3454 m (paO2 approximately 55 mm Hg) provokes a 50% increase in pulmonary pressure and a 20% increase in right ventricular weight, edema of both ventricles, particularly the right, and marked alterations in energy metabolism. Propranolol (4 mg/kg/day), administered 1 day before the transfer to high altitude and during the days of stay, prevents the increase in pulmonary pressure and in right ventricular weight and decreases myocardial edema, but has no effect on the metabolic alterations.

Altitude↗

Changes in biochemical properties of myocardial lactate dehydrogenase during exposure of rats to high altitude.

Exposure of normal rats to chronic natural hypoxia has shown the following effect upon catalytic properties of myocardial lactate dehydrogenase (LDH): significant increase of the two substrates pyruvate and lactate in tissue extracts; no changes in electrophoretic patterns of the enzyme; a slight enhancement of the activation energy of enzyme molecules; a significant increase in the Michaelis constant for pyruvate. Variations in biochemical properties of LDH appear after 12 ueeks of life in high altitude environment. These adjustments may be related to the stimulation of anaerobic metabolism induced by altitudinal hypoxia. Changes in LDH biochemical parameters seem adaptative.

Acclimatization↗

Changes in energetic metabolism of rat myocardium during acclimation to high altitude.

The results reported in this paper refer to the modifications of energetic equilibrium in the myocardium tissue, involved by altitude chronic hypoxia. Experiments have been done on adult rats (males and females) placed in the Jungfraujoch station, in the Alps, at 3,500 m. The obtained data were compared to control animals, bred in Geneva. On the first days of stay at high altitude, a significant fall of tissue energy charge, due to the non-modified enzyme levels in comparison with the controls, was observed. After several weeks of stay in chronic hypoxia, the metabolic modifications leading to the improvement of energy production and to the achievement of a new equilibrium state, take place. In acclimatized animals some good correlation, between the energy charge and the activity of glycolytic enzymes (PGK and PK) ensuring the ATP generation, is established.

Acclimatization↗

Determination of regional and central circulation times by the ascorbate dilution method.

The usefulness of the ascorbate dilution method in demonstrating intracardiac shunts and valvular incompetence is known. The ascorbate technique can also be applied to the determination of the transit time of regional vascular beds such as the coronary and the renal systems. Furthermore, the determination of central circulation times may be helpful in the diagnosis of caval obstruction. The method is safe, simple, inexpensive, and reliable.

Adolescent↗