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Biomedical subjects

P R Patterson

Publications and source records attributed to P R Patterson.

7 recordsLinked to original sources

Compartment syndrome--current trends in Scottish practice.

The results are reported of a postal survey into current trends in the management of compartment syndrome and the use of compartment pressure monitoring (CPM) within Scottish trauma units. The majority of consultants in the study felt that all patients, especially the obtunded, with suspected compartment syndrome should be diagnosed using a combination of clinical review and CPM. 73% had CPM devices available representing an increase of 27% compared with previously published UK data. 43% improvised a device using a standard CVP/Arterial-line, transducer and monitor. Marked variation in threshold pressure was noted with the majority recommending perfusion pressure (PP) of diastolic blood pressure (DBP)--intracompartmental pressure (ICP) < 30 mmHg for intervention. We have found no published evidence to suggest that CPM in itself is harmful. Although a marked variation in intervention threshold exists in the literature, we would support a perfusion pressure of < 30 mmHg as being a safe, familiar and conservative intervention threshold, particularly when used in conjunction with clinical assessment.

Body Fluid Compartments↗

Minocycline in the antibiotic regimen of cystic fibrosis patients: weight gain and clinical improvement.

Minocycline hydrochloride was given to 100 patients with cystic fibrosis of the pancreas for periods of 3 months over a broad-spectrum antibiotic drug rotation which lasted 2 years. Increased weight gain and some clinical improvement was seen during treatment with minocycline. Those patients with severe disease gained more weight than those with mild or moderate disease, and males gained more than females. When minocycline hydrochloride was not the drug in use, patients lost weight and their health declined.

Adolescent↗