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Biomedical subjects

P R Sutton

Publications and source records attributed to P R Sutton.

At least 19 recordsLinked to original sources
PubMed1992

Rearrangements occurring adjacent to a single Ty1 yeast retrotransposon in the presence and absence of full-length Ty1 transcription.

The structures of two unusual deletions from the yeast Saccharomyces cerevisiae are described. These deletions extend from a single Ty1 retrotransposon to an endpoint near a repetitive tRNA(Gly) gene. The deletions suggest that unique sequences flanked by two nonidentical repetitive sequences, or bordered on only one side by a transposable element, have the potential to be mobilized in the yeast genome. Models for the formation of these two unusual deletions were tested by isolating and analyzing 32 additional unusual deletions of the CYC1 region that extend from a single Ty1 retrotransposon. Unlike the most common class of deletions recovered in this region, these deletions are not attributable solely to homologous recombination among repetitive Ty1 or delta elements. They arose by two distinct mechanisms. In an SPT8 genetic background, most unusual deletions arose by transposition of a Ty1 element to a position adjacent to a tRNA(Gly) gene followed by Ty1-Ty1 recombination. In an spt8 strain, where full-length Ty1 transcription and, therefore, transposition are reduced, most deletions were due to gene conversion of a 7-kb chromosomal interval flanked by a Ty1 element and a tRNA(Gly) gene.

Base Sequence↗
PubMed1990

Fluoridation.

Explore the source record for details and available documents.

Dental Caries↗
PubMed1988

Fluoridation: a fifty-year-old accepted but unconfirmed hypothesis.

The fifty-year-old fluoridation hypothesis has not been confirmed. Despite this, millions of people are still medicated with fluoride by government decree, on the assumption that this process has been proved to be entirely safe, and very efficacious in reducing dental caries. In fact, the scientific basis of fluoridation is very unsatisfactory. It is promoted, in the main, by emotion-based 'endorsements' rather than by scientifically-acceptable evidence.

Australia↗
PubMed1985

Tooth eruption and migration theories: can they account for the presence of a 13,000-year-old mesiodens in the vault of the palate?

A case of a mesiodens in the vault of the palate of a skull estimated to be approximately 13,000 years old is presented. The currently cited theories of tooth eruption were considered, and it was concluded that only the newly formulated BVT (blood vessel thrust) theory of tooth eruption can account for the migration of this mesiodens into that position.

Alveolar Process↗
PubMed1985

The blood-vessel thrust theory of tooth eruption and migration.

The Blood-Vessel Thrust Theory is a new hypothesis regarding the forces which produce the normal eruption of teeth, and the movement of 'nonerupted' teeth through bone away from their normal position in the jaws. It points out that the flow of blood through the vessels of the dental pulp, and of the tissues surrounding the tooth, must produce hydrodynamic and hydrostatic forces within the blood vessels, and that these forces have a resultant towards the tooth crown, thus causing the tooth to move, crown first, through the bone during normal eruption or abnormal tooth migration.

Humans↗