PubMed Health⌕ Search

Biomedical subjects

P Rödbro

Publications and source records attributed to P Rödbro.

14 recordsLinked to original sources
PubMed1977

Bone composition and vitamin D after Pólya gastrectomy.

With the aim of evaluating bone phosphorus/hydroxyproline ratio (P/Hypro) as an index of osteomalacia, this bone index and the bone mineral content (BMC) have been investigated together with other indices of calcium metabolism in 27 gastrectomized patients. None of the patients had clinically manifest bone symptoms. The mean values of bone P/Hypro, BMC, plasma calcium and plasma magnesium were subnormal; the mean values of serum parathyroid hormone (iPTH) and plasma alkaline phosphatase were elevated. Mean serum 25-hydroxycholecalciferol (25-OH-D) did not differ from normal. A significant positive correlation was found between bone P/Hypro and serum 25-OH-D, but no significant correlation between bone P/Hypro and BMC. Serum 25-OH-D and bone P/Hypro were significantly lower and serum iPTH was significantly higher in a subgroup of 12 patients with no regular supplementary intake of vitamin D. In conclusion, the gastrectomized patients had blood biochemical evidence of a mild vitamin D insufficiency and the low bone P/Hypro values can be explained by mild osteomalacic changes in bone.

Adult↗
PubMed1977

Long-term reproducibility of bone mineral content measurements.

The long-term reproducibility of bone mineral content (BMC) measurements using two identical equipments for two-dimensional fore-arm scanning, was measured in normal persons and aluminium standards (corresponding to normal persons and severely osteopenic patients). The mean coefficient of variation in normal subjects measured for one year was 1.4%. The data were used to estimate that this equipment can measure BMC in osteopenic patients with a long term reproducibility of 1.7%, which is sufficient for use in the clinically relevant range of calcium balance.

Adult↗
PubMed1976

Selection of routine method for determination of glomerular filtration rate in adult patients.

The precision and reporducibility of three different clearance methods as used in clinical routine assessment of glomerular filtration rate (GFR) were investigated in 51 patients: total [51Cr]EDTA plasma clearance (E); 24-hr endogenous creatinine clearance (C); and creatinine clearance estimated from the plasma creatinine concentration, weight, and sex- and age-dependent mean creatinine excretion rate (c). The precision and reporducibility (coefficient of variation) for single determinations were, in patients with E greater than 30 ml/min, 5.5 and 4.1% (E); 26.9% (C); and 23.2 and 11.0% (c). The corresponding figures for E less than 30 ml/min were 11.6 and 11.5% (E); 21.9% (C); and 21.4 and 6.5% (c). The precision of C could not be ameliorated by excluding single deviating determinations, but only by excluding patients for whom the precision of 15.5% for mean of three determinations of C (total material) could be reduced to 10% by excluding 25% of the patients. The present data indicate that E in most cases is the method of choice for assessment of GFR in clinical routine work. For changes in renal function, especially at low functional levels, c may be of value.

Adult↗
PubMed1976

Optimum time of blood sampling for determination of glomerular filtration rate by single-injection [51Cr]EDTA plasma clearance.

We have investigated the influence on reproducibility of total [51Cr]EDTA plasma clearance (E) of various times and number of blood samples in patients with normal (13 patients) and low (14 patients) renal function. The study aims at fixing a clinically useful procedure suitable for all levels of renal function. Six different types of E were evaluated with time periods for blood sampling between 3 and 5h after tracer injection, and the variation from counting radioactivity, sc, was determined as part of total variation, st. Optimum mean time t(E), for blood sampling was calculated as a function of E, as the mean time giving the least change in E for a given change in the 'final slope' of the plasma curve. For patients with normal E, sc did not contribute significantly to ST, and t(E) was about 2h. For patients with low renal function sc contributed significantly to st, and t(E) increased steeply with decreasing E. The relative error of sc from fixed E types was calculated for all levels of renal function. The results indicate that blood sampling individualized according to predicted E values is not necessary. A sufficient precision of E can be achievef for all function levels from three blood samples drawn 180, 240, and 300 min after injection.

Blood Specimen Collection↗
PubMed1976

Systematic difference of extrarenal background in left and right kidney regions at renography.

The problem of whether the extrarenal sodium [131I]iodohippurate background activity at renography is higher in the right kidney region than in the left was studied by analyzing data from 711 consecutive renographies. The 3 conical collimators had an aperture diameter of 78 mm, an internal diameter at crystal surface of 50 mm, and a skin-to-crystal surface distance of 115 mm, thus allowing the radioactivity of almost the entire kidney to be registered with equal efficiency.

Humans↗
PubMed1976

Comparison between total and renal plasma clearance of [51Cr] EDTA.

The total plasma (Et) and renal plasma (Er) clearances of [51Cr]EDTA were measured simultaneously in 40 patients with a wide range of renal function. The regression equation was Et identical to 0.997 Er+4.1; the slope of the regression line was not significantly different from 1.00, and the intercept differed significantly from zero. The results suggest that [51Cr]EDTA has a significant extrarenal clearance of approximately 4 ml/min, independent of renal function. The data are used to correct the total [51Cr]EDTA plasma clearance, measured by a simplified method, to yield a rapid, accurate, and precise measurement of glomerular filtration rate for routine clinical use.

Edetic Acid↗
PubMed1975

Determination of fractional renal function in renography with and without individually [131I]albumin-determined blood background.

Fractional renal function was determined from 122 renographies using three different blood background subtractions: with individually [131I]albumin-determined correction factors, with direct subtraction of the thorax background curve. In the latter case a systematic error was introduced, since the right kidney's fractional function was overestimated and that of the left kidney accordingly underestimated. With mean correction factors the deviation from 'true' fractional function (as determined individually with [131I]albumin) was negligible. We recommend this principle since it is simple and sufficiently accurate.

Adult↗
PubMed1975

Bone mineral content in the forearm measured by photon absorptiometry. Principles and reliability.

A method for estimating total bone calcium is reported. The method is based on two-dimensional scanning photon absorptiometry on the distal part of the forearm. The following factors are investigated: precision of measurements on standards and human subjects; linearity; the effect of varying bone orientation; amount of fat and soft tissue; and the relation between weight and content of calcium and phosphate. The results show that the method is eminently suitable for rapid, easy, and atraumatic measurement of local bone calcium in vivo.

Adult↗
PubMed1975

Estimation of total body calcium from the bone mineral content of the forearm.

The representativity of forearm in bone mineral content (BMC) measurements for estimation of total body calcium is investigated in this article. It is shown that there is a very high correlation between weight and calcium content of examined bone pieces, that there is a high correlation between weight of individual bones and BMC values, that the BMC values from various parts of the skeleton are reasonably well correlated, that the weight of individual bones is highly correlated to the weight of total skeleton, and that there is a reasonably high correlation (r=0.85) between BMC measurements in the distal part of the forearm and total weight of the skeleton. It is concluded that BMC measurements of the distal part of the forearm give an estimate of total body calcium.

Bone and Bones↗
PubMed1975

Bone mineral content and estimated total body calcium in normal adults.

Bone mineral content (BMC) was measured in 127 normal subjects, 54 men and 73 women, aged 21-70 years. BMC was a function of age and sex; it was therefore found relevant to give normal values in 10-year age groups for each sex. BMC was furthermore related to height, weight, surface area, and muscular strength but the biological scatter was not reduced by correction for surface area. The normal range is expressed in arbitrary units, mmol calcium/m, and calculated total body calcium in grams. Since the latter expression, after determination of the necessary proportion constants, is independent of apparatus construction and location of measurement, and is dependent on the selection of the reference population, it is recommended that the result be expressed in these grams. It is furthermore concluded that the BMC measurement is excellently suited for determining the effect of treatment on osteopenia in a group of patients but rather unsuitable for diagnosis of osteopenia in the individual patients, whereas two other conditions (as regards clinical applicability) occupy an intermediate diagnosis of osteopenia in a group of patients.

Adult↗
PubMed1975

Bone mineral content and estimated total body calcium in normal children and adolescents.

Bone mineral content in the distal part of the forearm was measured in 301 normal children and adolescents aged from 7-20 years to estimate total body calcium in these age groups. From year 7 to 9 and from year 15 to 20 the mean values in boys were significantly higher than those in girls. In the lower age groups there was a slow increase in estimated total body calcium with age, followed by a sharp increase at the age of puberty.

Adolescent↗