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P RIOPEL

Publications and source records attributed to P RIOPEL.

9 recordsLinked to original sources
PubMed1963

Effects of oxyphenbutazone (tandearil) on plasma seromucoids. II. In postoperative inflammation.

The efficacy of oxyphenbutazone (OPB) in the control of postoperative inflammation was investigated, and previous findings were extended on the rate at which the inflammatory response of plasma seromucoids was significantly modified by this drug. Eighty - five surgical patients (hemorrhoidectomy, 39; vaginal hysterectomy, 23; tonsillectomy, 14; submucosal resection of nasal cavity, 9) were studied by the double-blind method. OPB was administered orally in a daily dosage of 400 mg. with a priming dose on the evening before surgery. Effective control of postsurgical inflammation was achieved in 34 of 46 treated subjects as compared with similar results in eight of 39 controls. Control of postoperative pain was pronounced when OPB was used. One patient developed an urticarial rash. Chemical studies were carried out in 65 surgical patients (39 treated with OPB; 26 controls). In the postoperative phase, mean plasma seromucoid values increased from presurgical levels by 39% in controls and by 13.9% in OPB-treated subjects. Hence, results of this clinical trial clearly demonstrate the usefulness of OPB in the control of postsurgical inflammation. Moreover, results of the chemical studies are in accordance with those previously obtained in animals.

Analgesics↗
PubMed1963

Effects of oxyphenbutazone (Tandearil) on plasma seromucoids. I. In experimental inflammation.

Some metabolic aspects of seromucoids in inflammation were elucidated by the use of oxyphenbutazone (OPB), a potent anti-inflammatory drug whose mode of action is fundamentally different from that of corticosteroids. Inflammation was induced in rats by intraperitoneal injection of 3 ml. of 1% formaldehyde. This resulted in an immediate and remarkable increase in the plasma seromucoid level, which persisted for 23 days. The subcutaneous injection of OPB (100 mg./kg.), six hours after formal-dehyde treatment, significantly lowered plasma seromucoids. The decrease was more pronounced when the same dosage of OPB was administered 24 hours before formal-dehyde injection. However, no effects were detected with single or repeated injections of OPB in a dosage of 50 mg./kg. Furthermore, the plasma seromucoid levels of normal rats were uninfluenced by OPB. From these results, it was postulated that some mediating or stimulating factor was released at the site of injury that was responsible for the increased synthesis of seromucoids and that was inhibited by OPB. The lowering effect of OPB was in contrast to the action of ACTH and cortisone, which latter do not alter the increased plasma level of seromucoids. These results further confirm that plasma seromucoid regulation is independent of the pituitary-adrenal mechanism.

Analgesics↗