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Biomedical subjects

P Ramdavon

Publications and source records attributed to P Ramdavon.

6 recordsLinked to original sources
PubMed1993

[Reoperations for recurrent atrial septal defect].

The authors discuss seven cases of recurrent atrial septal defect (ASD) without an inferior border which were treated by surgery. A typical clinical picture of the anomaly with arterial hypoxemia being the leading symptom was encountered in all cases. The main cause of the complications was overestimation of the indications for Lewis' operation, i.e. ASD suturation. A good clinical result was produced in all cases of a repeated intervention with ASD repair with a graft.

Adolescent↗
PubMed1993

[The interventricular functional-morphological correlations in chronic overloading of the primarily intact left heart in a model of experimental vasorenal hypertension].

This investigation shows the work of the heart as an integral functional system where each of the ventricles plays its own vital role, especially in the case where only one ventricle is pathologically affected. Moreover, the changes in the right heart have been carefully studied, thus showing its immediate involvement in cases of left heart hemodynamical overloading. The experiment was carried out on 178 mature rabbits with a model of vasorenal arterial hypertension based upon coarctation of the abdominal aorta just above the renal arteries. Arterial and intraventricular parameters of blood pressure were registered and morphological investigation involved transmission electron microscopy of the left and right ventricular myocardia, especially paying attention to mitochondrial changes in the cardiomyocytes. The right ventricle reacts at the same time as the left ventricle, although it shows a more intensive function and reaches decompensation earlier than the left heart.

Animals↗
PubMed1993

[An assessment of the differences in the reaction of the left and right heart ventricles to a long-term rise in systemic arterial pressure in experimental renoprival arterial hypertension in rabbits].

Different parameters of the function of the left and right heart ventricles were investigated in rabbits with renoprival arterial hypertension during a period of 52 weeks from the moment of modelling the process. As a result, this process was divided into 3 stages: 1. The establishment of compensation (1-4 weeks); 2. Compensation (6-10 weeks); 3. Decompensation (22-52 weeks). In mathematical prognosis of the time-course changes in the parameters associated with different stages of the process, the prognostic data were shown to be close to the experimental ones during prognosis for the left ventricle in the second stage, and for the right ventricle in the first stage. While prognosing for the left ventricle in the first stage and for the right ventricle in the second stage, the data obtained were significantly different from the experimental ones. These results suggest a conclusion that the right ventricle adapts itself to cardiac overload quicker than the left ventricle, but it also gets "worn out" quicker than the latter due to the conditions of "rigid" functioning in the second stage of the process when the adaptive potentials of the heart are limited.

Animals↗
PubMedDate not supplied

[Dynamics of the interrelationships of functional and morphologic parameters of the left and right ventricle in coarctation and decoarctation of the ascending aorta].

The contractile and ultrastructural parameters of the left and right ventricles were studied in rabbits 3 weeks after ascending aortic coarctation by a third of the baseline diameter. In other rabbits, the same parameters were studied 1, 2, 3, and 4 weeks after recovery of the normal aortic lumen following three weeks of its narrowing. It was found that a rapid recovery of the parameters under study did not occur after decoarctation despite the fact that left ventricular overload was abolished. A fortnight after decoarctation there was a profound increase in the contractility of the two ventricles and three weeks there was a significant enhancement of cardiomyocytic mitochondrial function.

Animals↗
PubMedDate not supplied

[Myocardial capillary changes and formation of the "wear complex of the hypertrophic heart].

The myocardial capillary network was experimentally studied in aortic coarctation and decoarctation. Two factors were found to play an important role in the development of the wear complex of the hypertrophic heart. These included 1) failure of the myocardial capillary proliferation rate to keep up with increases in cardiac mass and 2) lag of mitochondrial hyperplasia and myofibrillar hypertrophy.

Animals↗