[Value of the sequential treatment with defibrinating agents and plasminogenic urokinase in thromboembolic disease].
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Biomedical subjects
Publications and source records attributed to P Raynaud.
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This paper describes a test for diagnosing pregnancy in the cow based on the detection of blastocyst antigens in the maternal blood circulation. Rabbit anti-bovine embryo serum was agglutinated with the sera of non-pregnant cows to obtain specific antibodies. These rabbit antibodies were then absorbed on latex beads which could then be used for the standard passive agglutination reaction. This diagnostic technique was tested on 415 animals. The results on pregnant cows were successful in 78 p. 100 of the cases (confidence interval: 69-86 p. 100) and on non-pregnant cows 94 p. 100 of the time (confidence interval: 90-97 p. 100). This test is independent of the status of the ovaries and of the pregnancy stage. Detection is reliable from day 26 after coitum.
The imaging of the cardiac cavities with appropriate tracer materials (99 m Technetium or 113 m Indium), the recording of intracardiac dilution curves by radionuclide angiography and dynamic studies by gamma cinecardiography give global and regional parameters of left ventricular function which are reliable and reproducible: an index of cardiac output, intracardiac circulation times and ventricular volumes. The assessment of left ventricular contraction and global and regional ejection fractions is facilitated by coupling the gamma camera and the electrocardiogramme and computer analysis of the results. "First passage" recordings may be used to differentiate the right from the left heart chambers. "Equilibrium" studies give detailed information at rest, under stress (or leg-raising) and under pacing and/or trinitrin. Average and maximal rates of contraction derived from the ejection fraction and left ventricular contraction times are indices comparable to the rate of fibre shortening. The calculation or regional parameters point by point such as the ejection fraction, contraction time and ejection volume gives a more accurate and sensitive estimation of left ventricular function than the global left ventricular indices. They are many practical applications in cardiology especially in coronary artery disease: monitoring the changes in the acute phase of myocardial infarction, the selection of patients for aorto-coronary bypass surgery and their pre- and post-operative controls. These non-invasive, easy and reliable cardiac studies justify the development of laboratories of nuclear cardiology within departments of cardiac physiological investigation.
28 patients with primary congestive cardiomyopathy in heart failure identified by cineangiographic criteria (end-diastolic volume greater than 120 ml/m2; parietal thickness less than 11 mm; normal coronary angiography), underwent 131-Cesium and 201-Thallium myocardial scintigraphy in antero-posterior and LAO projections, and 17 also underwent angiocardiography with 99 Technetium labelled albumin. This condition usually gives an appearance of an enlarged heart with diffuse or localised (antero lateral wall) hypofixation, dilatation of the left ventricular, left atrial and right ventricular cavities and a very low ejection fraction with diffusely hypokinetic wall motion. Radio-Isotopic methods may help discriminate primary and ischaemic cardiomyopathy but are not diagnostic. A low ejection fraction and marked diffuse hypofixation are poor prognostic indices. Radio-Isotopic methods are valuable in the classification of primary cardiomyopathy.
Lysozyme is present in the salivary secretions and a low level has been reported for the bile and the pancreatic juice. It has been found to be absent from the digestive material of the rabbit stomach and small and large intestines as well as from the intestinal secretions taken from temporary fistulae placed at the duodenal, jejunal, ileal and colic levels. However, secretions obtained by permanent intestinal and gastric fistulae showed high enzyme levels. Lysozyme is thus of probable plasmatic origin. The question of Paneth cell secretion is still to be determined.
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In the Rabbit, during excretion of hard feces, a correlation exists between the stock of bacterial carbohydrates at the caecal level and the intensity of the bacterial lysis observed in the proximal colon.
The results of Isoprenaline stress tests, exercise electrocardiography and coronary arteriography were compared in 90 patients suspected of having coronary insufficiency. The technique used was a continuous intravenous infusion starting with an initial dosage of 3.8 gamma/minute and increasing progressively until the heart rate was equal to or greater than 130/minute, and sustained for three minutes. The same criteria of "positivity" were used as in the exercise test but only electrical charges which persisted or appeared 3 minutes after stopping the infusion were taken into consideration. In this series the sensitivity and specifity of the Isoprenaline test was greater than the exercise test if coronary arterial narrowing equal to or greater than 50% is considered significant. The prognostic values of positive tests which are classified in three groups according to the severity of the coronary artery disease, and the value of the isoprenaline test in the diagnosis of moderate single vessel disease are emphasised.
50 patients were investigated by both left ventricular cine-angiography, and "balanced" gamma-cine-cardiography in the frontal and LAO positions. Measurements of the ejection fraction and the mean and maximal speeds of contraction were made by the two techniques. The correlation was good (r = 0.89 for the ejection fraction). A morphological analysis of the dynamic findings in the two methods in the 12 cases with discordered left ventricular kinetics showed that once again the results were very similar. A numerical presentation of the data from the radioisotope studies was made either as a group of sequential ventricular contours successively from diastole to systole, or to give a functional picture which would provide the value for one kinetic paramter at any one time (for example, the regional equivalent of the ejection fraction). To overcome the problems of superimposition in the RAO position in the "balanced" technique, the recordings of the first radioisotope study in RAO were combined with a study of balance in 50 other patients, and the correlation was excellent. These two isotope techniques, which can be carried out in the same examination and which may be repeated without risk, perfectly complement each other, and very few of the results were incapable of interpretation.
The authors report four cases of right atrial palsy associated with tachycardia and/or slow atrial rhythm from the left auricle in elderly subjects with a past history of cardiac failure with atrial fibrillation for about ten years; they were digitalised and had cardiac failure, and in addition there was one perisinus block and one paroxysmal or persistant complete block situated above the bundle of His and probably above the AV node itself, secondary to the condition of atrial palsy. This probably represents an intermediate stage between chronic atrial fibrillation and atrial palsy in an elderly subject. These cases require careful intracavitary investigation, and often treatment by pacemaker and digitalis.
The distribution of volatile fatty acids (VFA) in digestive tract contents of Rabbits was studied using gas chromatography. VFA concentration in the posterior zones of the digestive tract were very high and comparable to values for ruminants. The distribution of the three principal VFA was different from that found in polygastric as well as monogastric animals. In Rabbits, butyrate concentration is higher than that of propionate. A selective absorption of butyrate, resembling an active transport, has been shown in the colon.
Volatile fatty acids (VFA) were measured by gas chromatography in the digestive material of Rabbits subjected to:--alimentary fast for 48 hours;--stercoral fast for 96 hours. A 48 hour alimentary fast caused a substantial drop in VFA in the digestive tract, butyric acid was the most affected, its concentration falling below that of propionate. Fasting for 48 hours did not cause a total cessation of fermentation. Stercoral fasting did not diminish the quantity of VFA in the digestive tract. VFA production was even augmented in the posterior parts (caecum and colon).
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