Biomedical subjects

P Reade

Publications and source records attributed to P Reade.

12 recordsLinked to original sources

PubMed1995

Characterization of genetically distinct subgroup of Candida albicans strains isolated from oral cavities of patients infected with human immunodeficiency virus.

During the course of a study of oral Candida albicans strains from 60 human immunodeficiency virus-infected patients over a 2.5-year period, 18 of the 295 C. albicans isolates had genomes that failed to hybridize with a C. albicans-specific DNA probe (27A). These strains were germ tube positive and chlamydospore positive and were identified as C. albicans by the ID 32C test (API Systems, Montlieu, France). These strains were analyzed for the presence of two other C. albicans-specific DNA segments by PCR. The first was a C. albicans 1,348-bp species-specific sequence, and the second was a 1,059-bp C. albicans repetitive element. The probe 27A-hybridizing strains yielded PCR products which differed from those of the nonhybridizing strains. Five of these genetically atypical C. albicans strains and 98 of the C. albicans strains were then analyzed for purported virulence factors. The genetically atypical C. albicans strains, in comparison with typical C. albicans strains, produced greater amounts of extracellular proteinase (P = 0.038, Student's t test), adhered to a greater degree to buccal epithelial cells (P = 0.018, Student's t test), and were less susceptible to the antifungal drug 5-flucytosine (P = 0.0003, Mann-Whitney test). Analysis of these strains with other common antifungal drugs showed no statistically significant variation in susceptibility. The results of this study indicated that these genetically atypical C. albicans strains possess increased virulence in comparison with typical C. albicans strains.

AIDS-Related Opportunistic Infections↗

PubMed1992

Referral patterns of patients with oral squamous cell carcinoma, Australia.

Early diagnosis is an important factor affecting the prognosis of patients with oral cancer. Delays in diagnosis have been variously reported as being linked to the patient, the clinician or both. The purpose of this study was to investigate the referral patterns of patients with oral cancer by medical and dental practitioners, in order to assess the delays in diagnosis and to establish the reasons for these delays. 51 consecutive patients diagnosed with oral mucous membrane squamous cell carcinoma were retrospectively reviewed. In this study it was found that over one-third of the patients (38%) delayed seeking professional advice for more than 3 months after first being aware of the lesion. Initial delays in diagnosis of oral cancer was identified in one-third of the cases (17 patients), with antimicrobial medications prescribed and denture adjustments constituting the most frequently administered inappropriate therapy. General medical practitioners were more likely to encounter and refer patients with more advanced (T4) primary oral cancers than their dental colleagues. The findings of this study raise the concern that lack of patient awareness and inappropriate clinical management prevails in a community that should be better informed.

Adult↗

PubMed1992

Oral ulceration.

Oral ulceration is a common problem. The presentation is often very similar, irrespective of the underlying cause. This paper illustrates some of the more commonly encountered forms of oral ulceration.

Diagnosis, Differential↗

PubMed1989

Prognostic features of value in the management of temporomandibular joint pain-dysfunction syndrome by occlusal splint therapy.

Fifty consecutive patients diagnosed as suffering from a temporomandibular joint pain-dysfunction syndrome that required occlusal splint therapy were studied. Particular attention was given to observable features that could be analyzed during resolution as indicated by using successive visual analogue scales for pain assessment. By photographing occlusal registrations before and after each splint adjustment visit it was shown that the stabilization of occlusal patterns as resolution progressed gave a good indication of the success of treatment in most patients. In patients in which stabilization of patterns occurred but pain continued there was an indication of a complicating psychosocial disorder.

Adolescent↗

PubMed1978

Hypnotherapy in the treatment of oro-facial pain.

A continuing study at the Oro-Facial Pain Clinic. The Royal Dental Hospital of Melbourne has demonstrated that hypnotherapy is a useful tool in the management of previously resistant, chronic facial pain disorders, discomfort conditions and dental phobic illness.

Adolescent↗

PubMed1976