[Health and environment. General introduction].
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Biomedical subjects
Publications and source records attributed to P Recht.
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The Commission of the European Communities has been carrying out scientific investigations on asbestos for some years. The principal activity has been the regular meetings of two European Communities panels of scientific consultants concerned primarily with the pathology of the asbestos-related diseases, asbestosis and mesothelioma. In addition, the Commission has carried out a number of comparative studies on the measurement of asbestos in various media, using both gravimetric and microscopic techniques.
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In 1977, the Commission of the European Communities initiated an intercomparison study to determine the single administration oral LD50 value in rats of each of 5 chemicals with the aims of comparing experimentation technologies, determining the degree of variation in the results and the various parameters used to establish the LD50 value, and establishing a common protocol for the determination of the LD50 value. Sixty-five laboratories in 8 countries took part in the first study. The significant variation in protocol may have led to the large interlaboratory variation observed in the results. Therefore, participating laboratories carried out a second study using a common protocol, preceded by a pilot study. A total of 100 laboratories in 13 countries participated. A majority of results of the second study are currently being analyzed, and the indications are that the interlaboratory variation has been significantly reduced.
Wounds involving the nail bed should be covered immediately by an autograft, a homograft or a heterograft to prevent dystrophy and loss of sensation. The author's technique in performing such grafts is described.
In children the treatment of pulp injuries should amed at conservation. In amputations, replantation should always be tried owing to the high possibility of success and subsequent of functional recovery. In non-specialized workers the simplest and shortest operative procedure (natural healing or skin graft) should be preferred to ensure the quickest possible return to work. In specialized manual workers such as musicians and typists, the return of the sense of touch along with a functional distal joint is essential. In these cases all necessary reconstructive procedures are indicated. In women the cosmetic appearance is most important and requires precise nail reconstruction. Special considerations apply to certain digits: 1. The thumb should be kept as long as possible, without bone sacrifice, requiring plastic procedures to ensure good skin cover. When possible these should employ local flaps which may restore sensation, especially significant on the ulnar side of the pulp. If these local flaps are not possible, sensitive flaps (KUHN/HOLEVICH type) or sensory island flaps (MOBERG, LITTLER or HILGENFELDT type) may be used. 2. In the little finger conversation is almost as important as this digit is mobile, autonomous and represents the usual contact of the ulnar side of the hand. 3. In the index finger, employed manity for fine actions, DIP mobility is important for good pick up ability. Local flaps are preferred. If impossible sensitive flaps should be used on the radical aspect of the pulp, to avoid functional substitution of the middle finger for the index.
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