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Biomedical subjects

P Renon

Publications and source records attributed to P Renon.

At least 19 recordsLinked to original sources

[Study by radiolabelling of the residual time of a therapeutic gel in the nasal fossae].

The residence times in the nose of the liquid and gel forms of the same therapeutic preparation were compared in 7 healthy subjects. A 50 microliters drop of the preparation, labelled with Tc99m, was placed down the head of the inferior turbinate, and the kinetics of its clearance from the site of deposition was monotired using a gamma camera, during 60 minutes for the liquid and 120 minutes for the gel. The average times for removal of 50% of the labelled material from the site of deposition were 10.3 minutes and 28.6 minutes for the liquid and gel forms respectively. The slower removal of the gel form is probably due to a mechanical effect, and seems to affect the whole nasal passage. The contact time between the preparation and the mucosa is increased in this galenic form and this should improve the efficiency of the preparation.

Adult

[Results of the evaluation of nasal respiration in maxillo-mandibular malocclusion in children. Apropos of 53 cases].

The authors measured nasal resistance in 53 children aged 5 to 13 years treated for bite disorders. Comparison of the results with a normal control group of children of the same age demonstrated that major nasal incompetence was 4 times more common in the group of children with orthodontic abnormalities. Nasal incompetence with permanent buccal respiration leads to disordered growth and modification of the morphogenesis of the naso-ethmoid-maxillary unit. Adaptation of deglutition and phonation to these new conditions produces modifications in the tension of the velo-pharyngo-facial and pharyngo-hyoglossal musculo-aponeurotic bands with a tendency to produce more vertical mandibular growth in children. The prevention of nasal incompetence in children and its treatment are important for coherent facial growth and guarantee the stability of the results of orthodontic treatment.

Adolescent

Electronystagmography and saturation deep diving at 4.6 MPa.

In the course of the ENTEX V and VIII saturation deep diving experiments at 4.6 MPa for 12 d, electronystagmography monitoring was performed on divers before, during, and after the stay in the diving chamber. In a vestibular sense, these dives were well-tolerated subjectively, clinically, and infraclinically by the divers. However, a decrease in the nystagmus induced by caloric stimulation was seen in 4 out of 8 divers during the confinement period at 0.2 MPa and in 6 out of 8 divers upon reaching 4.6 MPa, followed by variable responses dependent on the subject, with total recovery on reaching the surface. These results are explained on one hand in terms of the thermal conductivity of helium, and on the other in terms of a rough form of HPNS.

Calorimetry

[Complications of decompression of the internal ear during diving].

Inner ear decompression sickness belongs inner ear barotrauma. It occurs after a dive with factors of risk. The diagnostic needs an accurate history and physical examination which allows emergency treatment: therapeutic recompression, then hyperbaric oxygen and perfusions of vasodilators + corticoids. The symptomatology is mainly vestibular and the discussion between peripheric and/or central lesions is still open.

Adult

[Current status of objective measurements of nasal airflow].

Objective quantitative measurements of nasal airway patency are badly known and used in clinical practice. However lot of difficulties may be overcame. The modern instruments have a good preciseness and the results are given with reproducibility. The authors sum up principal indications, wether medical or surgical, and insist on a necessary severe methodology.

Humans

[Bacteriological study of maxillary sinusitis].

Suppurated maxillary sinusitis are frequent diseases. Diameatic puncture allows bacteriological investigations. Our results are positive in two thirds of cases. The bacterial flora is very varied, whose identification and antibiograms involve efficient treatment with daily washing and in situ antibiotherapy.

Adolescent

[Solitary tumors of the vagus nerve in the carotid sulcus: neurofibroma and schwannoma. Apropos of 2 cases].

Neurinoma of the vagus is a rare disease (less than a hundred cases published) and even more exceptional when it develops in the carotid cervical sulcus. Indeed, nevous tumors of the neck are usually situated in a high position, in the lateo-pharyngeal space. Clinical diagnosis is difficult: a chronical enlarged lymph node is the usual suggestion. Nevertheless, two signs, albeit inconsistent are very important: cough and bradycardia on palpation of the tumefaction. Enucleation, when possible, is the best procedure for exeresis, leaving the recurrent fibers intact. But in most cases, the tumor cannot be separated from the nervous fibers and the vagus nerve must be severed at both ends. This results in definitive paralysis of the homolateral vocal cord. Microscopically, it is not always easy to distinguish between neurofibroma and schwannoma because both tumors share a common cytogenetic origin and many intermediary forms are found. Only electronic microscopy can solve litigious cases. The importance of this distinction is not only speculative, a schwannoma assumes a solitary course but a neurofibroma may belong to Recklinghausen's disease. Both schwannoma and the rare solitary neurofibroma of the cervical portion of the vagus nerve can be surgically removed, their prognosis is favorable. nervous tumors of the neck in Recklinghausen's Disease must not be operated on account of possible aggravation.

Adult

[Electrogustometric threshold in diabete and chronic ethylism. Survey on 230 patients (author's transl)].

This study completes a previous one in which the authors tested the electrogustometric threshold in 300 normal subjects used as controls. The collected datas has been computerized on a programable calculator according to a lognormal model. Comparison between the electrogustometric threshold in diabetic patients, ethylic ones and controls demonstrate that they are statistically different. More than a half of the diabetics and ethylics have abnormaly high electrogustometric thresholds. The responses have been studied as a function of the evolution of the disease, of the clinical form and of gravity. Diabete and chronic ethylism do not disturb the gustatic function at the same speed and with the same intensity: one year evolution is at least necessary for diabetics, and ten years for ethylics in order to detect abnormal electrogustometric thresholds. But if the action of ethylic intoxication is slower, it determines the most important gustometric deteriorations.

Alcoholism