Anti-cardiolipin antibodies in progressive systemic sclerosis (PSS)
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Autoantibodies↗
Biomedical subjects
P Riboldi
Publications and source records attributed to P Riboldi.
The SL/Ki system in connective tissue diseases: incidence and clinical associations.
In a clinical and serological study carried out on 516 subjects with different connective tissue diseases, anti-SL/Ki autoantibodies were found in 12% of patients with systemic lupus erythematosus, 14% of patients with mixed connective tissue disease, 18% of patients with different kinds of vasculitides, and 3% of patients with Sjögren's syndrome. In SLE patients, no significant clinical association was found with the SL/Ki system, but the incidence of the antibody was nearly three-fold higher in males than in females. Most sera contained other autoantibodies; a statistically significant serological association has been found between SL/Ki and PCNA antibodies (p less than 0.05).
Adolescent↗
Antinuclear antibodies in progressive systemic sclerosis.
Sera from 84 patients with progressive systemic sclerosis (PSS) were tested for the presence of antinuclear antibodies by immunofluorescence on HEp2 cells and gel immunodiffusion. Fluorescent antinuclear antibodies were detected in 80 subjects with PSS (95%). Ninety-three percent of patients with CREST syndrome and 3% of those with diffuse scleroderma had a centromere staining. Precipitating antibodies were found in 57% of PSS sera and identified as anti-Scl 70 in 42 cases (50%). This specificity was found in 42 of 70 subjects with diffuse scleroderma (60%); another patient was positive for anti-nRNP antibodies, and 5 more sera from PSS patients showed precipitin lines of unknown specificity. No serum from 14 patients with CREST syndrome was positive for anti-Scl 70 antibodies. Significant relationships have been found between centromere staining and CREST syndrome (p less than 0.0005) and between the presence of anti-Scl 70 antibodies and the diffuse form of scleroderma (p less than 0.0005). The latter specificity is strongly associated with grainy speckled pattern on HEp2 fluorescence (p less than 0.0005). These data suggest that anti-Scl 70 antibodies and anti-centromere antibodies are useful markers for different subgroups of patients with PSS.
Adult↗