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Biomedical subjects

P Richards

Publications and source records attributed to P Richards.

At least 19 recordsLinked to original sources
PubMed1992

Toe graphaesthesia as a discriminator of brain impairment: the outstanding feet for neuropsychology.

Because of the vulnerability of the medial surfaces of the cerebral hemispheres to the consequences of shear forces, we hypothesized that quantitative sensori-motor deficits for the feet would be strong indicators of general brain dysfunction. On the basis of the Halstead-Reitan Impairment Index, 28 adults who had received closed head injuries were assigned to perfectly normal, normal, or (mildly to severely) impaired groups. Foot tap and finger tap as well as agnosia and graphaesthesia for the fingers and toes were measured. Deficits in toe graphaesthesia were the most powerful group discriminator. Potential usefulness of haptic/motor, finger/toe comparisons for recording the progress of degenerative diseases, such as AIDS, is also suggested.

Adult↗
PubMed1979

Yellow nails and nephrotic syndrome.

A patient is described who simultaneously developed the yellow nail syndrome and nephrotic syndrome. Treatment of the nephrotic oedema coincided with return of normal nail growth.

Female↗
PubMed1979

Long-term outcome in children with temporal lobe seizures. I: Social outcome and childhood factors.

One-hundred children, diagnosed as having temporal lobe epilepsy and reported on in 1966, have been followed into adult life. In this 1977 survey they have been coded into four social outcome categories, A, B, C and D. A: 33 per cent are found to be seizure-free and independent; B: 21 per cent are socially and economically independent but are receiving anticonvulsant treatment and are not necessarily seizure-free; C: O9 per cent are dependent either on their parents or in institutions; D: 5 per cent died under the age of 15. Biological factors ascertained and coded in childhood are related to adult outcome. Eight adverse factors emerged: an IQ below 90, onset of seizures before 2 years 4 months, five or more grand mal attacks, temporal lobe seizure frequency of one per day or more, a left-sided focus, the hyperkinetic syndrome, catastrophic rage and special schooling. The presence of first-degree relatives with seizure disorders was a good prognostic sign. Disorderly homes in childhood did not significantly affect adult outcome. All but one of those achieving Group A status had received normal schooling. In general, the prognosis for children with limbic seizures is clear before the end of adolescence. A simple count of the number of childhood adverse factors predicts adult outcome at a high level of significance.

Adolescent↗
PubMed1979

Long-term outcome in children with temporal lobe seizures. II: Marriage, parenthood and sexual indifference.

One-hundred unselected children with clinical and EEG evidence of temporal lobe seizures were followed into adult life. Data related to marriage and reproduction are analysed. Female survivors, if not totally handicapped, are nearly all married; surviving males who are not totally handicapped more often remain single. Early remission of seizures in males is associated with marriage: seizures continuing through adolescence are associated with sexual appetitive indifference. The female probands have produced children at a rate three times greater than the male probands. The findings have implications for understanding the development of male secual appetite. The epidemiology and genetics of these forms of seizures must take account of much greater fitness on the distaff side of the pedigree. The likelihood of marriage and parenthood would appear to rest on a few biological factors usually recognisable before the end of childhood.

Adolescent↗
PubMed1979

Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life.

One hundred children with temporal lobe epilepsy were followed into adult life. 85 per cent had had psychiatric problems in childhood. The occurrence of overt psychiatric disorder in adult life was low: of those survivors who were not gravely mentally retarded, 70 per cent were regarded as psychiatrically healthy. Overt schizophreniform psychosis has developed in 10 per cent of survivors. Males with continuing epilepsy and left-sided foci were at special risk: 30 per cent of such patients had become psychotic. No patient coded as having a right-sided focus in 1964 had become psychotic by 1977. Though 26 patients had had grossly disordered childhood homes, this factor had no significant relation to adult psychiatric disorder. Antisocial conduct marked the adult life of 12 patients. Their childhood codes showed that male sex, a focus contralateral to the preferred hand, and unremittent epilepsy marked this group. Low intelligence and childhood rages were also prominent. Treated neurotic and depressive illness was quite uncommon. Only five survivors have fallen into this category. Those patients escaping psychiatric ill-health are often notably extraverted and successful.

Adult↗
PubMed1979

Preparation of 52Fe and its use in a 52Fe/52mMn generator.

Clinically useful quantities of 52Fe have been prepared at the Brookhaven Linac Isotope Producer (BLIP) by bombarding manganese or nickel targets with medium energy protons. After chemical separation, 52Fe is loaded onto a generator column from which carrier-free 52Mn is eluted. The 52mMn generator is potentially useful in emission computed tomography.

Iron Radioisotopes↗
PubMed1978

Wasted women doctors.

Explore the source record for details and available documents.

Education, Medical, Continuing↗
PubMed1978

Comparison of the effects of keto acid analogues and essential amino acids on nitrogen homeostasis in uremic patients on moderately protein-restricted diets.

Comparisons of isonitrogenous supplements (1.2 g N) of essential amino acids and five keto acid analogues with four essential amino acids were made in seven patients with stable chronic renal failure (creatinine clearance, 4.6 to 16 ml/min) on moderately protein-restricted diets (4.60 to 7.8 g N per day). Full nitrogen balance data on the four patients who have already completed studies lasting 24 weeks are presented. No benefits of keto acid over amino acid supplements were observed. Two transient episodes of hypercalcemia occurred during keto acid treatment. There was no improvement of renal function with keto acids. Also, no carry-over effects were seen after keto acid treatment. It is concluded that any beneficial effects of keto acids in patients with chronic renal failure are only likely to occur in those taking a diet of less than 30 g protein daily.

Adult↗
PubMed1978

Metabolic studies with keto acid diets.

Five patients with chronic renal failure taking a diet containing approximately 5 g N throughout were studied during two periods of 1 month each. Nitrogen balance, urea metabolism, and incorporation of 15N from urea into albumin on diet alone or with a keto acid/essential amino acid supplement were measured. Keto acids produced a reduction of plasma urea, urea synthesis, and urea excretion and an improvement in nitrogen balance. In patients who demonstrated the greatest change on ketoacids, 15N incorporation also increased, but their total incorporation of urea nitrogen was not nearly sufficient to account for the improvement in nitrogen balance. The role of keto acids in protein anabolism is not solely or even mainly explained by promotion of nonprotein nitrogen reutilization.

Aged↗