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P Romero Colomer

Publications and source records attributed to P Romero Colomer.

12 recordsLinked to original sources
PubMed1986

Bronchial hyperreactivity in fresh stage I sarcoidosis.

In order to analyze the mechanism of airways obstruction seen in patients with early sarcoidosis, we have studied the bronchial reactivity in 12 patients with stage I sarcoidosis. The patients were given progressively increasing doses of methacholine to inhale. A fall of more than 35% of the SGaw was taken as the index of response. In 6 out of 12 patients (responders), we observed a dose-response curve similar to that seen in subjects with highly reactive airways. We could not find any difference between responders and nonresponders that could explain the diverse responses to the methacholine. Nevertheless, the modifications in different mechanical parameters showed that the inhaled methacholine induced two types of changes: a change in lung volumes (RV and FVC), observed mainly in the nonresponders, and a change in forced expiratory flows (FEV1, MEF25, and MEF50), observed in the responders. These types of response may suggest a different site of action of the inhaled agent. We conclude that the presence of airways hyperreactivity is frequent in early sarcoidosis and could perhaps explain the incidence of airways obstruction seen in this disease.

Adult↗
PubMed1984

Is it possible to predict pulmonary arterial hypertension from an exercise test?

In patients with chronic lung disease, the response to exercise can be impaired by ventilatory and/or circulatory disturbances. The response to a standard exercise varies according to the load in relation to the maximum load the subject can tolerate. Thus it seems more suitable to study the maximum tolerated, i.e. maximum workload expressed as VO2 max. We compared the results of VO2 max and pulmonary haemodynamic variables in 43 patients with chronic bronchitis. VO2 max ranged from 0.720 to 3.010 l/min. The relation between VO2 max and pulmonary artery pressure at rest or its increase with low level exercise was very poor, but there was a trend towards an increase in pulmonary vascular resistance in patients with low VO2 max, although a number of patients with low VO2 max had normal pulmonary vascular resistance. The ratio between heart rate at maximum workload and maximum heart rate according to age (heart rate obs/pred) was above 95% in the patients with pulmonary vascular resistance above 250 dyn.s. cm-5; it varied widely in the patients with normal or slightly elevated pulmonary vascular resistance. When VO2 max was below normal, and heart rate obs/pred low, it is probable that the decrease in VO2 max was due to ventilation impairment, or to a lack of cooperation. Oxygen pulse at VO2 max was also reduced in patients with high pulmonary vascular resistance, but a large range of values was observed in the rest of the patients. A high oxygen pulse at VO2 max however allows to rule out severe pulmonary artery hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

[A prospective study of pulmonary function in sarcoidosis (author's transl)].

A prospective study of 21 patients with sarcoidosis has been carried out. The patients were divided into two groups with (B) or without (A) radiological evidence of pulmonary involvement. The results show that there exists a correlation only between pulmonary restriction and the degree of radiological involvement, and that the alteration of the other measured functions (pulmonary diffusion, elasticity, peripheral airway involvement) is independent of the radiological stage of the disease. The findings are compared to those of the literature, and the relative value of the different tests in the diagnosis of pulmonary sarcoidosis are discussed.

Adult↗
PubMedDate not supplied

[Comparison of three exercise tests in a group of patients with chronic broncho-pulmonary disease (author's transl)].

In a group of 26 patients with various broncho-pulmonary diseases, the results of three types of exercise were compared : maximum supported power (PMS), maximum supported power + 20 W, and maximum tolerated power (PMT). The two first ones were made at constant power, the last one at increasing power (by 30 W, during three minutes). The comparison of the results indicates that there was no significant difference between the variables measured during PMT and PMS +20 W (power, oxygen uptake, cardiac frequency, oxygen pulse, ventilation). The changes in oxygen uptake, cardiac frequency, and ventilation, as the power increased, were not significantly different in the three types of exercise. In this group of patients, mean PMT was 121 W, mean PMS was 98 W, and the ratio PMS/PMT was thus 81%. To determine PMT first reduced the number of exercise-tests necessary to measure PMS (two or three tests depending on the patient).

Adult↗
PubMedDate not supplied

[Glycolytic metabolism during muscular excerise in chronic broncho-pulmonary disease without hypoxemia (author's transl)].

Maximum oxygen uptake (VO2 max) was measured in 11 chronic bronchitics without heart failure or hypoxemia at rest and during maximal work load, using a triangular type of excerise with increasing power (30 W/3 min). Glycolysis was studied in these patients during rectangular exercises lasting 10 minutes, in which power was increased by steps from an average value of 45 % to 72 and 94 % of VO2 max. The metabolic response of lactate in blood is similar to normal, during the limited performances of these patients.

Acid-Base Equilibrium↗