Biomedical subjects

P Romieu

Publications and source records attributed to P Romieu.

3 recordsLinked to original sources

PubMed2001

[Acceptability of computerized prescription writing in the hospital. Survey of 44 drug-prescribing physicians].

OBJECTIVES: The purpose of this work was to assess the acceptability of computerized prescriptions delivered by hospital prescribers. METHODS: The study was conducted in four clinical units of the Grenoble University Hospital that have a computerized prescription system. Forty-four physicians using the system responded to a questionnaire concerning the act of prescribing and the benefits or drawbacks of the system. RESULTS: Generally, the computerized prescription system was well accepted. The first drawback mentioned was the time spent manipulating the software. Safe prescription was noted as one of the advantages. Overall, organizational rather than technical factors appeared to condition the development of computerized prescription writing. CONCLUSION: Optimization of computerized prescription writing requires a reorganization of the care unit. Consultation schedules and working relations between the prescriber and other healthcares and hospital pharmacies will have to be adapted.

Attitude of Health Personnel↗

PubMed2001

The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities.

Steroids, synthesized in peripheral glands or centrally in the brain--the latter being named neurosteroids--exert an important role as modulators of the neuronal activity by interacting with different receptors or ion channels. In addition to the modulation of GABA(A), NMDA or cholinergic receptors, neuroactive steroids interact with an atypical intracellular receptor, the sigma(1) protein. This receptor has been cloned in several species, and highly selective synthetic ligands are available. At the cellular level, sigma1 agonists modulate intracellular calcium mobilization and extracellular calcium influx, NMDA-mediated responses, acetylcholine release, and alter monoaminergic systems. At the behavioral level, the sigma1 receptor is involved in learning and memory processes, the response to stress, depression, neuroprotection and pharmacodependence. Pregnenolone, dehydroepiandrosterone, and their sulfate esters behave as sigma1 agonists, while progesterone is a potent antagonist. This review will detail the physiopathological consequences of these interactions, focusing on recent results on memory and depression. The therapeutical interest of selective sigma1 receptor agonists in alleviating aging-related cognitive deficits will be discussed.

Animals↗

PubMed2000

Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.

The sigma1 (sigma1) receptor constitutes a particular target of cocaine believed to be involved in some of its behavioral effects. In the present study, its involvement in the rewarding effect of cocaine was examined using the conditioned place preference (CPP) procedure. CPP was induced in C57Bl/6 mice injected repeatedly with cocaine (20 mg/kg, i.p.). The selective sigma1 receptor antagonists NE-100 and BD1047 (1-10 mg/kg, i.p.) significantly attenuated or blocked the cocaine-induced CPP. Animals treated centrally with a sigma1 receptor antisense oligodeoxynucleotide failed to develop cocaine-induced CPP, unlike mismatch controls. The sigma1 receptor thus appears to be critically involved in the development of the cocaine-induced CPP and, in consequence, may constitute a promising approach to blocking cocaine reward.

Animals↗