Biomedical subjects

P Ronconi

Publications and source records attributed to P Ronconi.

22 records · Page 2Linked to original sources

PubMedDate not supplied

Distal oblique osteotomy of the first metatarsal for the correction of hallux limitus and rigidus deformity.

The purpose of this study was to evaluate the effectiveness of the distal oblique osteotomy of the first metatarsal (a triplanar shortening decompression osteotomy) to correct stage I and II hallux rigidus. The osteotomy cut is performed from dorsal-distal to plantar-proximal with an angle ranging from 35 degrees to 45 degrees in the sagittal plane. The capital fragment is then displaced plantarly and proximally and fixed with two screws and the metatarsal head is remodeled. From January 1993 through December 1995, a total of 26 patients (21 females and 5 males) underwent 30 distal oblique osteotomies of the first metatarsal (22 unilateral and 4 bilateral). The mean age of the patients was 54 years and the mean follow-up was 21 months. Patient satisfaction and objective clinical and radiographic measurements were evaluated. Patients' satisfaction was measured postoperatively with a modification of the University of Maryland 100-Point Painful Foot Center Scoring System. The results were: 84% good to excellent; 7% fair; and 9% poor. Radiographic measurements included: intermetatarsal angle mean: preop = 12.2 degrees, postop = 8.6 degrees; proximal articular set angle mean: preop = 11.8 degrees; postop = 10.3 degrees. There was no evidence of avascular necrosis in any of the cases. Clinical findings were: dorsiflexion of the first metatarsophalangeal joint: preop = 22 degrees, postop = 45 degrees; plantarflexion of the first metatarsophalangeal joint: preop = 15 degrees, postop = 18 degrees; hallux purchase power: preop = 2.5, postop = 2.3; pain on the second and third metatarsophalangeal joints, associated with excessive pressure on the central metatarsal heads: preop--present in 10 patients, postop--present in 12 patients; forefoot supination angle: preop = 13 degrees, postop = 7 degrees.

Adult↗

PubMedDate not supplied

Plasma carnitine levels and urinary carnitine excretion during sepsis.

Carnitine is an indispensable factor for the beta-oxidation of medium- and long-chain fatty acids, and it plays a possible role in the oxidation of branched-chain amino acids. Plasma and urinary levels of free carnitine and short-chain acyl-carnitines were studied in 67 surgical patients, after non-septic surgical procedures or during sepsis. The septic state was associated with increased urinary excretion of free carnitine (p less than 0.001), as well as with lower plasma levels of short-chain acyl-carnitines (p less than 0.001); the latter feature correlated with the level of hypermetabolism, as evaluated by the metabolic rate and by the arterial-mixed venous O2 difference. In 26 patients during total parenteral nutrition D, L-acetyl-carnitine was administered (100 mg/kg/24 hrs, in continuous iv infusion) and was associated, in septic patients only, with a significant decrease in the respiratory quotient, suggesting enhanced oxidation of low respiratory quotient substrates (fatty acids and/or branched-chain amino acids). Carnitine supplementation during total parenteral nutrition might be of theoretical benefit in some clinical conditions, such as sepsis, in which the following conditions coexist enhanced utilization of substrates whose oxidation is partially or totally carnitine dependent; prolonged absence of exogenous intake of carnitine (as in long-term total parenteral nutrition); eventual impairment of carnitine synthesis due to hepatic dysfunction; increased, massive urinary loss of carnitine.

Acetylcarnitine↗

PubMedDate not supplied

[Treatment of intermetatarsal neuromas with alcohol injection under US guide].

PURPOSE: The cause of intermetatarsal neuromas is unclear; the pathogenesis is, most likely, a mechanically induced degenerative neuropathy or an entrapment of the intermetatarsal nerve under the transverse intermetatarsal ligament. Treatment of intermetatarsal neuromas includes very simple methods, such as changing shoe styles, or more complex conservative treatments such as orthotic devices and steroid injections until surgical therapy. This study aimed to evaluate the neuroma's intralesional treatment with alcohol sclerosing injection as a viable alternative to steroid injections or surgery in persisting symptoms. MATERIAL AND METHODS: 23 patients with clinical symptoms of intermetatarsal neuroma and who had not undergone other treatments were treated with 30% alcohol applied under US guide. Each patient received from 3 to 7 applications at 7 to 10 day intervals. RESULTS: We performed 3 applications in 17 patients, 5 in 5 patients and 7 in 1 patient for a total of 83 applications with a technical success of 100%. A complete resolution of all symptoms was achieved in 91% of the patients. CONCLUSION: Alcohol sclerosing intralesional treatment under US guide is a viable alternative to conservative or surgery treatments in patients with intermetatarsal neuromas.

Adult↗

PubMedDate not supplied

Preoperative treatment of hydatid cysts with mebendazole.

Mebendazole--an anthelmintic drug which is known to have a lethal effect on hydatid cysts--was administered preoperatively to patients affected by Echinococciasis, in order to sterilize cysts and prevent surgical contamination. Our results suggest that mebendazole treatment (1500 mg/die for 25 days) was effective in ten out of eleven cases; no major toxic effect was observed.

Benzimidazoles↗