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Biomedical subjects

P Rosenblum

Publications and source records attributed to P Rosenblum.

6 recordsLinked to original sources
PubMed1982

Cysteamine reduces serum gonadotropin concentrations in adult male rats.

We have examined the effects of cysteamine on the hypothalamic-pituitary-gonadal axis of the adult male rat. A single subcutaneous injection of cysteamine (300 mg/kg) reduces significantly (p less than or equal to 0.05 serum concentrations of LH, FSH and T. Cysteamine blocked LH secretion induced by castration and administration of naloxone and LHRH. Neither acute nor chronic treatment (7 days) altered the hypothalamic LHRH content. These results suggest that cysteamine acts to reduce pituitary responsiveness to LHRH, resulting in lower mean serum gonadotropin and testosterone concentrations. It is possible, however, that cysteamine acts also at the hypothalamus to reduce LHRH secretion and/or at the testes to reduce testosterone release.

Animals↗
PubMed1982

Use of the Honan intraocular pressure reducer at The Wilmer Institute.

Our technique for the preparation of the patient for cataract surgery is discussed, with description of our use of the Honan intraocular pressure reducer (HIPR). Results of preoperative use of the HIPR in a prospective study of 21 patients and our retrospective experience with over 1,000 patients undergoing cataract surgery (with or without lens implantation) are discussed. The HIPR appears to be a safe and effective means of reducing intraocular pressure preoperatively when used with due care.

Cataract Extraction↗
PubMed1980

Hereditary Fuchs' Dystrophy.

We studied 102 individuals from 25 families in which at least one member was known to have Fuchs' endothelial dystrophy. We used slit-lamp examination, corneal pachymetry, and specular microscopy. We also examined pathology records which contained 79 cases of penetrating keratoplasties done solely for phakic Fuchs' dystrophy between 1940 and 1978. Although there was a marked predominance of females in our review of pathology records, our clinical study provided a more even sex distribution. There was a close correlation between the number of expected and observed affected first-degree relatives based on an autosomal-dominant mode of inheritance. We observed a fairly typical corneal pattern, beginning as a circumscribed area of central or paracentral cornea guttata, and thereafter expanding more horizontally than vertically with progression of severity. Fuchs' dystrophy appears to be a true corneal dystrophy with autosomal-dominant inheritance, a high degree of penetrance, and variable expressivity, with generally increased severity among females.

Adolescent↗
PubMedDate not supplied

Sudden visual loss secondary to an orbital varix.

A 45-year-old man presented with precipitous loss of vision and rapidly changing field defects in one eye. Computerized tomography and B-scan ultrasonography revealed a small orbital mass adjacent to the optic nerve. This was removed via lateral orbitotomy. On pathologic examination it was diagnosed as a small orbital varix. Drs. Frederick C. Blodi and Stephen Trokel comment on the case.

Exophthalmos↗