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Biomedical subjects

P Ruffieux

Publications and source records attributed to P Ruffieux.

9 recordsLinked to original sources
PubMed1997

Long-term assessment of chronic leg ulcer treatment by autologous skin grafts.

BACKGROUND: Chronic leg ulcers (CLU) are a common and major cause of morbidity. For this reason, we systematically perform autologous skin grafting. OBJECTIVE: Long-term evaluation of this treatment. PATIENTS AND METHODS: Among the 521 out-patients or those hospitalized for CLU between 1981 and 1993, we assessed 188 (118 women, 70 men, mean age 74 years, 144 grafts, 44 non-grafted). RESULTS: For the grafted CLU, there were 46 failures (17.5%), 152 (58%) healed in a mean time of 2.2 months and 64 relapsed (24.5%). For the non-grafted CLU, 3 did not heal (3%), 20 relapsed (22.5%) and 66 healed (74.5%) in a mean time of 4.7 months. All the patients who suffered from painful CLU mentioned a regression of pain after the graft. Finally, 87.5% of patients declared that they would accept a new graft. CONCLUSIONS: We did not note any real difference in closure and recurrence rates between grafted and non-grafted ulcers. This is most likely due to an important selection bias related to the methodology of our study. The grafted ulcers were more serious: they were larger (28.9 against 7.9 cm2) and older (11.1 against 5.6 months).

Adult↗
PubMed1997

Cellulitis after hip surgery: long-term follow-up of seven cases.

Cellulitis of the buttock after hip surgery is rarely reported, but raises concern about possible infection of the implant. In view of this we have investigated the frequency of previous hip surgery in patients with cellulitis of the hip and/or buttock and assessed for any predisposing factors. A review was made of the case notes of all patients admitted to our department with infectious cellulitis of the hip and/or buttock between 1981 and 1995. Seven of nine patients previously had had implantation of a hip prosthesis. The interval between skin infection and surgery was 7-9 weeks in two patients and 55-520 weeks in five. No infection of the implant was evident. The assumed portals of entry were gluteal fold intertrigo, tinea pedis, psoriatic plaque and a carbuncle of the buttock. The infection was successfully treated by intravenous antibiotics and, after a follow-up of a mean 64 months, no recurrence of cellulitis has been observed and only one aseptic loosening has occurred. Infectious cellulitis of the hip or buttock following hip surgery can occur secondary to impaired lymphatic drainage, a few weeks up to several years after surgery, without there being any infection of the orthopaedic implant.

Aged↗
PubMed1996

Livedo-like dermatitis (Nicolau's syndrome): a review of three cases.

We report 3 patients with typical features of livedo-like dermatitis. Emergency vasoactive therapy was administered to 2 of these patients, in whom the lesions healed completely. Although spontaneous resolution cannot be ruled out, we think that early recognition of this entity leading to rapid vasoactive treatment may limit the extent of thrombotic complications and the resulting tissue necrosis.

Aged↗
PubMed1994

Topical haemotherapy for leg ulcers.

Several growth factors, present in the plasma or delivered by blood cells, are involved in wound healing. We have treated 15 chronic atonic leg ulcers by topical application of autologous heparinized blood under a hydrocolloidal dressing. This 'topical haemotherapy' (THT) was applied every other day. After the first THT, 30% of the fibrinonecrotic material had already been removed. After a mean of 9 THT applications (range: 5-18), granulation tissue covered up to 75% of the surface of the ulcer (range: 30-100%) allowing autologous skin grafting. No local or systemic side-effects occurred during the treatment. THT is feasible and well tolerated; it is an easy and inexpensive treatment of chronic leg ulcers that rapidly induces granulation tissue. Growth factors and proteases produced by the blood cells could play a relevant role in this process.

Administration, Topical↗
PubMed1993

Superficial granulomatous pyoderma.

We report the case of a 66-year-old man presenting 2 chronic, slowly expanding skin lesions having clinical and histopathological characteristics of superficial granulomatous pyoderma. Sulfone treatment induced healing with scar formation.

Abscess↗