Increase in Alzheimer's disease: artifact or real?
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Biomedical subjects
Publications and source records attributed to P Rutter.
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OBJECTIVES: To define the presentation and management of patients presenting with abdominal aortic aneurysm (AAA) DESIGN AND SETTING: A prospective survey was carried out of all patients presenting to hospitals within the Oxford region. MATERIALS AND METHODS: Data were collected by one surgeon in each hospital. Full details were collected onto data sheets. RESULTS: One hundred and ninety patients presented, 141 electively, 46 with ruptured AAA and three with acute AAAs. In 53 patients presenting electively the aneurysm was small and surveillance started. Fifty-six patients underwent an operation, three patients died. Of 46 patients with a ruptured aneurysm 24 (52%) died. In 11 no operation was carried out and all of these patients died within 24 h. Operative mortality was 13 of 35 patients (37%). More patients with a ruptured AAA were transferred to the teaching hospital compared with a district general hospital (p < 0.05). This was reflected in a lower operative mortality in the teaching hospital. CONCLUSIONS: The presentation of AAA in this study was approximately 15 per 100,000 population. Approximately one-third of patients presenting electively had small AAAs which required surveillance. A further third underwent an operation, the remaining patients being unfit. Approximately one-quarter of patients with a ruptured aneurysm did not undergo an operation. The operative mortality was 37%.
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In wounds on the back of guinea-pigs an inoculum of 6 x 10(5) of Escherichia coli and of Bacteroides fragilis produced a frank infection rate of 27 per cent. Addition of a catgut or a braided nylon tie statistically significantly increased the rate to 56 and 48 per cent respectively. Prolene and silk produced much smaller, non-significant rises. The rate with polyglycolic acid was 18 per cent which, though not statistically significant, suggests the possibility that this material produces conditions unfavourable to multiplication of bacteria that produce this type of infection.
Measurements were made of the rates at which continuously cultured Streptococcus sanguis NCTC 7868 cells accumulated on the inside surfaces of narrow glass capillaries from suspensions of the bacteria flowing down the capillaries at different velocities. Initially, the rate of accumulation of bacteria on the clean walls of the capillary was rapid. The deposition rate decreased with time, however, resulting in a saturation coverage of the glass surface which was considerably less than a monolayer. Multilayer coverage of the tube surface by bacteria was only achieved when fresh nutrient was pumped over deposited cells. This was attributed to cell growth. Although theoretical considerations of the deposition of small particles on to the walls of a tube suggest that the initial deposition rate should increase with flow rate, this was not the case with cells grown at dilution rates of 0.2 and 0.5 h-1. It is suggested that this can be explained by a polymer bridging mechanism of attachment.
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