Biomedical subjects

P S Nsubuga

Publications and source records attributed to P S Nsubuga.

4 recordsLinked to original sources

PubMed2001

Efficacy of patient-delivered partner medication in the treatment of sexual partners in Uganda.

BACKGROUND: Patient-based partner referral (PBPR), which is the main method for treating sexual partners of patients with sexually transmitted diseases (STDs), has limited effectiveness. GOAL: The authors compared the efficacy of PBPR with patient-delivered partner medication (PDPM) among patients attending the Mulago STD clinic in Kampala, Uganda. STUDY DESIGN: A total of 383 patients (187 women, 196 men) with STDs were randomized to the PBPR or PDPM group. The proportion of sexual partners treated in either group was compared using the chi-square statistic by intention to treat for partners whose follow-up status was unknown. RESULTS: The two groups had similar background characteristics. Of the 237 partners elicited, 176 (74%) were reported treated in the PDPM group. In the PBPR group, in which 234 partners were elicited, 79 (34%) were referred to the treatment clinic. This difference was statistically significant (risk ratio [RR], 2.44; 95% CI, 1.95-3.07; P < 0.001). Furthermore, PDPM was more effective than PBPR for women and for casual partners for whom PBPR is considered difficult. For women, 86 of 103 partners in the PDPM group were reported treated, compared with 23 of 104 partners in the PBPR group (RR, 4.55; 95% CI, 2.92-7.08; P < 0.001). For casual partners, 18 of 51 (34%) were reported treated in the PDPM group, compared with only three of 45 partners (7%) who were referred in the PBPR group (RR, 1.43; 95% CI, 1.40-2.65; P < 0.01). CONCLUSION: Patient-delivered partner medication is more effective than patient-based partner referral in the treatment of sexual partners.

Adult↗

PubMed1999

Factors influencing sexual partner referral for sexually transmitted diseases in Uganda.

BACKGROUND AND OBJECTIVE: Patient-based partner referral has limited effectiveness. We studied factors associated with sexual partner referral among patients with sexually transmitted diseases (STDs) with a view of suggesting remedial action. GOAL: To examine the role of psychosocial variables vis-a-vis other variables in predicting sexual partner referral. STUDY DESIGN: A cross-sectional interview survey with 507 patients with STDs at an STD clinic in Kampala, Uganda. Multivariate analyses were used to identify independent predictors of sexual partner referral. RESULTS: Forty-two percent of the 599 partners elicited were referred. The independent factors that favored sexual partner referral were examined in the laboratory (adjusted odds ratio [AOR] 2.20, 95% confidence interval [CI] 1.20-4.05): psychosocial variables of intention (likelihood of referring the partner) (AOR 4.60, CI 1.58-13.36), self-efficacy (partner referral being easy) (AOR 3.22, CI 1.36-7.66), having a positive attitude toward partner referral (AOR 1.19, CI 1.06-1.33), and previous success in having referred a partner (AOR 9.78, CI 2.90-33.04). Other variables, such as age, sex, marital status, employment, and type of partner, that were significant on univariate analysis were not significant after multivariate analysis. CONCLUSION: By providing interventions to change the psychosocial variables, there is a high chance of improving compliance with sexual partner referral.

Adult↗

PubMed1995

Single-dose ampicillin/sulbactam versus ceftriaxone as treatment for uncomplicated gonorrhoea in a Ugandan STD clinic population with a high prevalence of PPNG infection.

During the period November 1989 to March 1991 a total of 330 patients (269 males and 61 females) with signs and symptoms of uncomplicated lower genital tract infections with Neisseria gonorrhoeae were treated at a sexually transmitted disease clinic in Kampala, Uganda. Patients were randomized for treatment with either intramuscular ampicillin/sulbactam (1 g ampicillin/0.5 g sulbactam), plus 1 g probenecid orally, or ceftriaxone (250 mg). In those cases where N. gonorrhoeae was isolated and the patients returned for a follow-up visit, 70/74 (95%) of the patients treated with ampicillin/sulbactam and 71/72 (99%) of those treated with ceftriaxone had favourable clinical outcomes. All 24 patients with penicillinase-producing N. gonorrhoeae (PPNG) treated with ampicillin/sulbactam had a favourable clinical outcome compared with 95% (20/21) of those with PPNG treated with ceftriaxone. The infecting pathogen was eradicated in 65/71 (92%) of the evaluable patients treated with ampicillin/sulbactam and in 60/63 (95%) of the ceftriaxone group. Both drug regimens were well tolerated and there were no reports of adverse drug effects. In summary, in a predominantly male group of clinic patients in Kampala, Uganda, ampicillin/sulbactam was as safe and effective as ceftriaxone in treating uncomplicated gonococcal infections of the lower genital tract caused by either PPNG or non-PPNG strains.

Adult↗

PubMedDate not supplied

Rapid sexually transmitted disease assessment in two developing countries.

Two rapid assessment studies of the magnitude of sexually transmitted disease (STD) were performed in Senegal and Uganda in 1989 and 1990. The study objectives were: to develop and validate STD indicators for the "rapid" assessment of the frequency of STD in populations; and to develop a standardized survey methodology to assess STD prevalence using these indicators. The World Bank, World Health Organization (WHO), and Senegal and Ugandan government officials desired a product similar to the WHO/UNICEF immunization coverage survey instrument, which is an accepted and proven methodology, implemented by national programs and donors worldwide. Three indicators were used: 1) past or present signs of selected STD; 2) symptoms as noted by a clinician; and 3) simple laboratory tests performed and results obtained at examination. Each indicator was validated against a confirmatory laboratory test considered the gold standard in indicating the presence or absence of an STD. Male military members, women seeking prenatal care, and female prostitutes were the three population groups chosen. With the exception of the rapid plasma reagin (RPR) test for syphilis, symptoms, signs, and simple laboratory tests failed to accurately predict STD in individuals in all three of these population groups. Indicators for the major STD other than syphilis among populations not seeking STD care will have to be the "gold standard laboratory tests" until easy-to-perform and low-cost alternatives are found.

Cost-Benefit Analysis↗