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Biomedical subjects

P SMITH

Publications and source records attributed to P SMITH.

At least 19 recordsLinked to original sources

ENTEROVIRAL SYNDROMES IN TORONTO, 1964.

Virological or serological investigations of 72 children in Toronto and environs, who were hospitalized between January and October 1964 with a variety of syndromes, revealed evidence of enteroviral infection in 29 subjects. Coxsackie B2 was the dominant enterovirus, being isolated from feces and/or cerebrospinal fluid (CSF) of three children with aseptic meningitis, three with pleurodynia, one with myalgia and one with pericarditis; four additional patients showed rising antibody titres to this virus. Coxsackie B1 virus, which has not been isolated in Toronto since 1950, was recovered from feces of three patients with pleurodynia, CSF of one patient with myalgia, and peritoneal fluid of a child with primary peritonitis; one patient with pericarditis showed a rising antibody titre to Coxsackie B1 virus. Coxsackie B3, B4 and Echo 23 viruses were associated with one case each of pleurodynia. Coxsackie B5 virus infected five patients with aseptic meningitis, and one each with pericarditis and myocarditis.

Canada↗

CHEMICAL TESTS FOR PHAEOCHROMOCYTOMA.

Urinary catecholamines, 4-hydroxy-3-methoxymandelic acid (V.M.A.), and metadrenalines have been estimated in 39 cases of proven phaeochromocytoma and in many hypertensive patients without phaeochromocytoma. The variation in excretion of these substances is described and their diagnostic significance discussed. Excretion of free catecholamines and metadrenalines showed a proportionately greater increase than of V.M.A. in patients with a phaeochromocytoma, and estimation of the first two appears to be diagnostically more reliable. Hingerty's method for catecholamines appears to be a satisfactory screening test, provided that 90 mug. is taken as the upper limit of normal, and estimation of metadrenalines is considered to be the best confirmatory test for phaeochromocytoma.

Catecholamines↗