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Biomedical subjects

P Saidi

Publications and source records attributed to P Saidi.

48 records · Page 3Linked to original sources
PubMed1979

Effect of factor XII deficiency on pregnancy and parturition.

The clotting parameter of a primigravida with factor XII deficiency was studied during her third trimester of pregnancy, labor and post-partum; and compared with those of her newborn male infant. Sharp increases in factors VII, VIII, IX, X and moderate increases in factors II and XI were documented during pregnancy and at labor. All factors had returned to normal or near normal levels 24 hours after delivery. Factor XII remained at 0.0 level throughout. In the infant the clotting factor levels reflected depression of vitamins K-dependent factors II, IX, and X and a factor XII level of 40.0%. No undue bleeding was noted in the mother at delivery or placental separation, and no bleeding manifestation was apparent in the infant. These findings suggest that factor XII does not play a major role in triggering or modulating the course of normal labor, nor is its absence necessarily associated with bleeding complications during parturition or placental separation.

Adult↗
PubMed1979

Heparin allergy accompanying acute renal failure.

A generalized cutaneous hypersensitivity reaction to a porcine heparin preparation was observed in a patient during the course of acute renal failure. Immunological studies, including gel diffusion and immunoelectrophoresis, suggested that the reaction was to a contaminant of the heparin and involved both IgG and IgE antibodies.

Acute Kidney Injury↗
PubMed1978

Methamphetamine intoxication. A speedy new treatment.

This communication describes the use of droperidol in methamphetamine poisoning. Droperidol antagonizes the central stimulatory effects of amphetamines producing a person who is indifferent to environmental stimuli, calm and cooperative. Coupled with an acid diuresis, causing a fivefold increase in the urinary concentration of methamphetamine and recovery of 66% of the ingested drug, a seriously intoxicated patient showed rapid improvement.

Adult↗
PubMed1976

Reduced erythrocytic deformability in megaloblastic anemia.

Ten patients with megaloblastic anemia had erythrocytes with reduced deformability. The mean half-life for erythrocyte filtration was 9.89 minutes in these patients, compared with 5,20 minutes in controls. The half-life was inversely related to the hemoglobin concentration. After adequate vitamin replacement therapy filtrability improved significantly. Two patients had thromboembolic disease, It is proposed that the reduced erythrocytic deformability reflects membrane rigidity that might ultimately lead to hemolysis.

Adult↗
PubMedDate not supplied

Nephrotic syndrome associated with hypocomplementemia in a 4-year-old boy with hemophilia B.

PURPOSE: The case of a 4-year-old boy with hemophilia B with inhibitor who developed nephrotic syndrome is described. The possible association between factor IX therapy and nephrotic syndrome in patients with hemophilia B is discussed. PATIENT AND METHODS: A chart review of a 4-year-old boy with hemophilia B and an inhibitor who developed nephrotic syndrome with transient hypocomplementemia was performed. In addition, a literature search was undertaken to determine the prevalence of this association and possible etiologic factors. RESULTS: Although the nephrotic syndrome was resistant to steroid therapy and Bebulin (Osterreichisches Institut für Haemoderivate Ges.M.B.H., Subsidiary of Immuno AG, Vienna, Austria) infusions were continued, the edema resolved and proteinuria decreased. Seven month later, proteinuria, accompanied by transient hypocomplementemia, increased again. A rise in factor IX inhibitor level was observed. The patient received no immunosuppressive therapy, and exhibited a continuous decrease in urinary protein excretion over the following months. DISCUSSION: A discussion about possible differential diagnoses and a review of the literature are presented.

Child, Preschool↗