Biomedical subjects

P Sansi

Publications and source records attributed to P Sansi.

3 recordsLinked to original sources

PubMed1991

Bone scan as a stratification variable in advanced prostate cancer.

The serial technetium 99 (99Tc) bone scans of 76 patients with Stage D-2 prostate cancers were reviewed. Sites of metastases in skeletal areas in decreasing order were vertebrae, ribs, pelvis, long bones, and skull. Patients with one or two involved skeletal areas had a significantly longer progression-free interval and survival time than patients with three or more bony areas of uptake. Bone scans might be used as a stratification variable in future prospective clinical trials of Stage D-2 prostate cancer.

Aged↗

PubMed1985

Nuclear medicine in the diagnosis of cardiac contusion.

In 16 patients with blunt trauma to the chest, the role of cardiovascular nuclear medicine was evaluated using anterior chest flow assessment, with first-pass ejection fraction of left and right ventricles and 99mTc-pyrophosphate scintigraphy. The radiopharmaceutical used was pyrophosphate, labelled with approximately 20 mCi 99mTc. The anterior chest flow and first-pass ejection fractions were initially obtained during the injection of 99mTc-pyrophosphate and were followed up 3 h later by anterior, LAO 45 degrees, and left lateral views of the chest, using an LFOV gamma camera with a data processor. The results were compared with serial cardiac enzymes studies, electrocardiograms and echocardiograms. Of the patients, 77% showed scintigraphic evidence of cardiac contusion. The intensity of activity varied from grades I to II; five patients had abnormal echocardiographic findings. Only two had abnormal ejection fractions, and one patient had evidence of left ventricular aneurysm along with poor ventricular performance. Cardiac enzymes were found to be the least helpful. Electrocardiograms, though non-specific for myocardial damage, were abnormal in 62% of the patients. Eleven of our patients had both abnormal ECG and increased PYP uptake. Even though there is no agreement as to which noninvasive parameter is more sensitive in the diagnosis of myocardial contusion, 99mTc-pyrophosphate scintigraphy, in conjunction with ECG, seems promising in this respect.

Contusions↗

PubMed1976

Thrombosis detection using radionuclide techniques.

Radionuclides have been used in the evaluation of intravascular thrombosis for several years. The most widely accepted nonimaging technique is I-125 labeled fibrinogen. It is commonly used for patients who have a high probability of developing a thrombus (e.g., those undergoing surgery). Other techniques are emerging as having value in thrombosis detection. These techniques include radionuclide venography and clot localization scanning techniques utilizing the affinity of clot for small radiolabeled particles, as well as imaging techniques using I-131 labeled fibrinogen. More recently, a number of the above-mentioned techniques have been applied to patient problems. The FDA ban on commercial radiolabeled fibrinogen in the United States has promoted the development of alternative techniques and the use of autologous fibrinogen. A number of other techniques for thrombosis detection have also been explored on a more experimental basis. They include the use of thrombolytic agents such as streptokinase, urokinase, and white blood cells, as well as platelets. The common lung or pulmonary perfusion scan using macroaggregates of albumin or microspheres radiolabeled also gives information as to the presence of thrombosis of embolus within the pulmonary arteries, by showing the effect upon the perfusion pattern. This review will explore in detail the principles, as well as the present and prospective usefulness of the techniques currently available.

Antibodies↗