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Biomedical subjects

P Sarasin

Publications and source records attributed to P Sarasin.

5 recordsLinked to original sources
PubMed1978

Active E rosette formation by human lymphoblasts.

The percentage of active and total E rosettes for lymphocytes cultured for 72 h both with and without phytohaemagglutinin (PHA) was evaluated in 20 normal subjects. A clear increase in the formation of active E rosettes by PHA-stimulated lymphocytes was demonstrated with respect to unstimulated lymphocytes. Our data gives further proof that the active E rosettes constitute a specific subpopulation of lymphocytes which represent functionally active T cells in the blood.

Adult↗
PubMed1977

Mitogenic action of neuraminidase.

A new effect of NCV on lymphocytes is demonstrated. This property is the capacity to act as a mitogen in and of itself. The possible mechanisms of this phenomenon are discussed.

Humans↗
PubMed1976

Peripheral lymphocytes in paraproteinemia.

In 22 cases of myeloma and 12 cases of benign paraproteinemia the functional situation of circulating lymphocytes was studied. The technique used was the incorporation of 3H-Thymidine after PHA stimulation. E rosette formation and immunoglobulin bearing cells were evaluated. A reduction of 3H-Thymidine incorporation in the blastic cells was seen in the patients with myeloma (2,942 +/- 421 cpm/10(6) lymphocytes in respect to 13,182 +/- 920 of the control group). The difference was statistically significant: p less than 0.001. In benign monoclonal gammopathies the reduction was moderate and was at the limits of the significance: 9,482 +/- 1,100. The percentage of E rosettes and of immunoglobulins bearing cells was normal. The different behaviour of the blastic response in vitro in the two groups of patients tested confirms that the respective condition of the immunocompetent system is clearly different. A possible interpretation of this type of behaviour is discussed.

Antibody Formation↗