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Biomedical subjects

P Schenck

Publications and source records attributed to P Schenck.

At least 19 recordsLinked to original sources
PubMed2000

Latex gloves use and symptoms in health care workers 1 year after implementation of a policy restricting the use of powdered gloves.

BACKGROUND: Latex sensitization related to glove use is a complex problem, and glove use policies that restrict exposure to powdered latex gloves alone may not provide adequate safety. This study explored health care workers' (HCWs') latex glove use and reports of related health symptoms 1 year after implementation of the latex glove replacement policy. METHODS: Two cross-sectional surveys. One was a population-based survey of HCWs at the institution (National Surveillance System for Hospital Health Care Workers); the second, a detailed survey of HCWs stratified by exposure to latex gloves (Latex Symptom Survey). RESULTS: The prevalence of symptoms of dermatitis reported by latex glove users was 40.3% (National Surveillance System for Hospital Health Care Workers) and 50.0% (Latex Symptom Survey). Symptom reports increased as exposure to latex gloves increased (pairs used per day, occupations with more glove use, working in higher exposure areas, more tenure, and more hours of use per day). Aerosol symptoms and urticaria related to latex glove use were reported much less frequently than were rash, chapping, itching, or redness. HCWs, even those with skin symptoms, continued to choose latex gloves in more than 80% of the cases. CONCLUSIONS: Stepwise preplacement evaluation at employee health clinics is recommended to identify and protect employees sensitized to latex. The medical community needs more understanding and education about latex gloves, latex sensitization, and available alternatives.

Academic Medical Centers↗
PubMed1995

Synthesis and degradation of hyaluronate by synovia from patients with rheumatoid arthritis.

OBJECTIVE: Hyaluronate degradation was analyzed in cultures of healthy tissue and tissue obtained from patients with rheumatoid arthritis. METHODS: Arthritic and healthy synovial tissues were incubated in culture with [3H]glucosamine. Labelled hyaluronate was extracted and its size determined by gel filtration. The production of low molecular weight hyaluronate was analyzed by pulse-chase experiments. Radical production was measured by a cytochrome C reduction assay. RESULTS: Healthy tissues and some arthritic tissues that did not contain significant amounts of granulocytes produced high molecular weight hyaluronate. In contrast, arthritic tissue infiltrated with granulocytes released low molecular weight hyaluronate. Pulse-chase experiments suggested that hyaluronate was degraded in these arthritic tissues. Exogenous hyaluronate was degraded only by intact tissue, but not by cells in culture obtained from synovial membranes of synovial fluids. Hyaluronate degradation was accompanied by massive oxygen radical production. Radical scavengers protected hyaluronate from degradation in synovial tissue. Some protection was achieved by superoxide and catalase or by methionine and complete protection by the iron chelators diethyltriaminepentacetic acid or deferoxamine mesylate. CONCLUSION: Degradation of hyaluronate in arthritic synovial tissue may be inhibited in tissue culture by radical scavengers.

Arthritis, Rheumatoid↗
PubMed1988

Monoclonal antibodies against herpes simplex virus type 1-infected nuclei defining and localizing the ICP8 protein, 65K DNA-binding protein and polypeptides of the ICP35 family.

The production and properties of monoclonal antibodies raised against herpes simplex virus type 1 (HSV-1)-infected cell nuclei are described. Biological and immunochemical assays revealed that these antibodies recognize four different proteins in HSV-1-infected cells. Four antibodies reacted with the major DNA-binding protein (ICP8) and six with the 65K DNA-binding protein. Two antibodies detected the ICP35 family of proteins and one antibody bound to a protein with an apparent mol. wt. of 60K. Immune electron microscopy showed that the major DNA-binding protein had a patchy distribution, whereas the 65K DNA-binding protein was evenly spread in the infected cell nuclei. The 60K protein as well as the polypeptides of the ICP35 family were preferentially found associated with the viral capsid.

Animals↗
PubMed1978

Radiation dose and labeling of hippuran.

Renal morphology and renal function were studied with iodine-123-hippurate in 98 patients with various renal diseases. Sequential scintigraphy with iodine-123-hippurate demonstrates much better renal blood flow, morphology and function than iodine-131-hippurate. A method of labeling hippurate in a short time (2 h) with high efficiency (95--100%) is described. Radiation exposure to various organs was calculated and significant differences in radiation exposure to the thyroid are demonstrated.

Hippurates↗
PubMed1975

[Liquor-scintigraphic findings with Yb 169-DTPA in cerebro-atrophic processes].

Liquor-scintigraphic examinations were carried out with Yb 169-DTPA in two patients, who were offering - clinically as well as by pneumo-encephalographic findings - the picture of a cerebro-atrophic process. Especially the first case showed the typical course and symptoms of Alzheimer's disease. A "stasis" of the radionuclide, lasting for 48 hours, was manifesting liquor-scintigraphically herein, in the course of which there was - initially - a weak representation of the ventricles. However, the complete clinical picture of a communicating hydrocephalus did not show up. In the second case, an undisturbed liquor circulation and absorption, to a great extent topically and temporally undisturbed, were observed. The question arises whether Alzheimer's disease is manifesting together with such a disturbance of the liquor circulation, already described also by other workers. The second case makes clear that the liquor space scintigraphy cannot be used as only diagnostic method in all cerebro-atrophic processes.

Aged↗