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Biomedical subjects

P Schilling

Publications and source records attributed to P Schilling.

7 recordsLinked to original sources
PubMed2000

PANORAMA: an integrated Web-based sequence analysis tool and its role in gene discovery.

As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-accessible software package that performs a variety of informatics analyses on a given DNA sequence and returns a visual and interactive representation of the results. Its design is modular, so that further sequence analysis tools can be integrated with minimal effort. The utility of PANORAMA is demonstrated in the analysis of 650 kb of human genomic DNA from chromosome region 3p21.3, a region of potential tumor suppressor genes involved in lung cancer, breast cancer, and other forms of cancer. PANORAMA aided in the discovery of genes and alternate splice forms of known exons, in the demarcation of intron-exon boundaries, and in the identification of promoter regions and polymorphisms, all of which contributed to a better understanding of the region. PANORAMA is available on the World Wide Web at http://atlas.swmed.edu.

Animals↗
PubMed1990

[Cardioactive contaminants and actual active ingredient content of various digitalis preparations].

To establish possible cardioactive impurities which have not been totally separated while isolating the compound from plant material several preparations containing digoxin (NOVODIGAL = beta-acetyldigoxin, LANITOP = beta-methyldigoxin and LANICOR = digoxin) were analyzed by HPLC-chromatography after careful extraction. Impurities were found (digoxigenin, digoxigenin-monodigitoxosid, digoxigenin-bisdigitoxosid) which on the one hand occur as natural lanatosid-derivates in digitalis leaves but on the other hand also are described as possible metabolites of digoxin in human organism. The experiments have shown that the results of studies in metabolization of digoxin without knowledge of purity of the substance applied have to be interpreted with care.

Digitalis Glycosides↗
PubMed1984

Erythrocyte and dietary zinc in adolescent females.

Erythrocyte zinc has been suggested as an index of zinc status. This study was undertaken to investigate the possible relationships of erythrocyte zinc concentration to age, physical maturity, and zinc intake of teenage girls of two races. Dietary zinc was calculated from two 1-day food recalls, and erythrocyte zinc was determined for over three hundred 12-, 14- and 16-yr-old girls in Oklahoma and Virginia. Erythrocyte zinc concentration increased and the intake of zinc from the diet decreased after attainment of menarche. Among girls of the same menarcheal state, age was not related to zinc intake, but concentration of zinc in erythrocytes increased with each 2-yr age increment in those that were past menarche. Results did not show a direct relationship of erythrocyte zinc values to calculated intakes of zinc by adolescent females. Black and white races did not differ in either zinc intake or red cell zinc content.

Adolescent↗
PubMed1983

The iron status of Black and white female adolescents from eight Southern states.

Hb, hematocrit, plasma iron, and transferrin saturation were measured in approximately 1000 girls aged 12, 14, or 16 yr in eight southern states. The iron status parameters did not differ significantly among the three age groupings or between menstruating and nonmenstruating girls. Blacks had significantly lower mean Hb (p less than 0.0001), hematocrit (p less than 0.0001), and transferrin saturation (p less than 0.05) levels than whites and a greater proportion of Blacks exhibited low Hb (p less than 0.05) and low hematocrit levels (p less than 0.01). Adjusting for dietary iron intakes and per capita income levels did not adequately account for significant race differences for iron status parameters. These findings support the contention that genetic as well as environmental factors are responsible for the frequently reported Black-white differences in Hb and hematocrit levels.

Adolescent↗