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Biomedical subjects

P Schmidt-Peter

Publications and source records attributed to P Schmidt-Peter.

10 recordsLinked to original sources

The development of osteosarcoma in four-fold selected group of patients.

Patients with osteosarcoma have been submitted to four-fold selection using parameters previously shown to be associated factors. These are sex, age at onset, haptoglobins and histological type. Further data have been added to the final resulting sequence of patients. In the four-fold selected group there is an age-dependent AB0 distribution which confirms the relevance of the criteria used and, consequently, the influence on sarcoma development. It can be assumed from these investigations that the occurrence of osteosarcoma is modified by several genetically fixed factors (HP type, sex, AB0 group).

ABO Blood-Group System

[The value of computed tomography in monitoring the preoperative chemotherapy of osteosarcoma].

Computed tomography was performed in 45 patients with osteosarcomas before and after preoperative chemotherapy. Changes of bone alterations, intramedullary tumour spread and the size of soft tissue masses are computer tomographic criteria for tumour response after chemotherapy. The computed tomography decision of responder or non-responder was correct in 37/45 patients. In comparison with conventional x-rays CT was superior. CT is a reliable method for preoperative extension diagnosis and for the decision-marking for limb-saving operations.

Adolescent

[Malignant fibrous histiocytoma of soft tissue. Possibilities and limitations of computed tomography].

Computed tomography was performed in 27 patients with confirmed malignant fibrous histiocytoma of the soft tissue. Compared with the CT results obtained in other tumours of the soft tissues. CT accuracy in malignant fibrous histiocytoma was only 74%. Non-typical attenuation values, diffuse tumour growth and non-typical contrast enhancement are discussed as reasons for the diagnostic understaging or overstaging of these soft tissue tumours. A higher accuracy was found on ultrasound examination with regard to tumour extension. Bone destruction was better visualised by CT. A base-line CT is recommended postoperatively for the earlier detection of recurrent tumours in further investigations.

Adult

[Malignant bone tumors--possibilities and limits of surgical treatment].

Surgical treatment of patients for malignant bone tumours, its possibilities and limits, is expounded in this paper on the basis of results and experience obtained from more than 330 cases. Reference is made to adjuvant chemotherapy which today is an indispensable component of complex treatment at least for osteosarcoma and Ewing's sarcoma. Described are ablative procedures, ranging from amputation to hemicorporectomy, and limb-saving operations, including implantation of tumour-specific endoprotheses which has assumed growing importance in recent years.

Amputation, Surgical

CT evaluation of osseous tumors.

Computed tomography was performed on 153 patients with histologically proved bone tumors. CT has been found to be important for demonstrating the extent of the lesion, in aiding decisions about the operative approach, especially in tumors of the shoulder girdle and pelvis, and also for planning of localized surgery to maintain extremities. CT is of limited value in determining the nature of tumors. CT has proved efficacious in the detection or ruling out of tumor recurrences and in the assessment after chemotherapy or radiation therapy.

Bone Neoplasms

[Diagnostic imaging of peripheral soft tissue tumors with special reference to computed tomography].

The further development of modern therapeutical procedures in the treatment of soft tissue tumors requires an improvement of radiological diagnostics. The diagnostic values of X-rays, angiography, sonography and computed tomography is estimated critically. The results of own CT examinations in 120 patients with soft tissue tumors and of 50 ultrasound examinations show the importance of these methods in the extent diagnosis of soft tissue tumors. Ultrasound or CT- guided biopsy are helpful to prove the definitive diagnosis. These methods have reduced the use of angiography.

Adolescent