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Biomedical subjects

P Schräpler

Publications and source records attributed to P Schräpler.

16 recordsLinked to original sources
PubMed1980

[Diagnosis of renal cysts (author's transl)].

Renal cysts were demonstrated in 48 out of 1000 non-selected patients investigated with sonography. Large cysts (mean diameter 4.8 cm) were also shown by urography. Smaller cysts (mean diameter 2.5 cm) could be diagnosed only by sonography. This method enabled establishment of the diagnosis in 3 out of 5 patients in whom there was radiographic suspicion of tumours. Ultrasound may also be used in the patient with renal failure. Powerful mobile equipment permits investigation at the bedside of the severely ill patient. Demonstration or exclusion of space occupying renal changes should make use of ultrasound as a primary diagnostic tool.

Diagnosis, Differential↗
PubMed1978

[The effect of benzbromarone on fasting-hyperuricemia as a model (author's transl)].

The effect of daily therapeutic doses of 100 mg benzbromarone (Normurat) and 2.0 g probenecid on the purine metabolism of 40 test subjects was investigated. Fasting-hyperuricemia was used as the model and particular attention paid to the mechanisms of renal elimination. Urate concentration remains under the solubility threshold when benzbromarone is administered, in contrast to medication with probenecid. The significantly greater hypouricemic effect of benzbromarone correlates with a significant rise in the excretion and clearance of uric acid in comparison to probenecid, accompanied by a stronger depression of tubular reabsorption. Serum levels, clearances and reabsorption rates demonstrate the prolonged effect of the benzofurane derivative Normurat even during strict fasting. Supplementary allantoin and urea determinations gave no indication of increased enterobacterial uricolysis. Normurat was well tolerated, side effects were not noted.

Adolescent↗
PubMed1978

[The uricosuric effect of benzbromaron and probenecid under fasting conditions (author's transl)].

As we could demonstrate in a group of 39 obese subjects submitted to a 15-days period of absolute fasting, the developing hyperuricemia coincides with a decrease of uric acid clearance following an increase of the reabsorbed amount of filtered uric acid. After daily application of 2 g probenecid a marked uricosuric effect was detectable only during the first 3 days, while in the following time this effect was perceptible only impaired. As a reason for the diminution of efficacy the fasting-dependent urinary acidosis is discussed, which leads to low tubular concentration of the pharmacon by non ionic diffusion. In a dosage of 100 and 300 mg/day benzbromaron proved to be a much more potent uricosuricum. Additionally, related to the increase of dose the unproportional strong fall of serum uric acid levels, which stood in contrast to higher rations of uric acid excretion under a lower dose and which exceeded the dose-depending increase of uric acid clearance, indicated an additional extrarenal site of action. The depression of PAH-excretion after application of 2 g/day probenecid, which comes about the competitive inhibition, did not occur under 100 mg/day benzbromaron. This difference signifies, that benzbromaron does not develop its uricosuric effect by influencing the tubular transport system, which is specific for PAH and probenecid.

Benzbromarone↗
PubMed1977

[Changes of kidney function in obese subjects during absolute fasting (author's transl)].

In 28 obese subjects the influence of a 15-days fasting period on the kidney function was investigated by continuous measurement of the clearances for creatinine, urea and uric acid. In the course of fasting time the serum concentrations of creatinine in comparison to the initial value significantly increased, the creatinine clearance maximally decreased about 40%. The serum concentrations of urea were found lower, whilst the clearance of urea increased. Moreover a distinct increase of the serum levels in connection with a significant decrease of the uric acid clearance was to be observed. Under conditions of strict fasting changes of the kidney function are evident, whose intra- and extrarenal reasons are discussed.

Adult↗