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P Simonsson

Publications and source records attributed to P Simonsson.

38 records · Page 3Linked to original sources

Postprandial effects of dietary phosphatidylcholine on plasma lipoproteins in man.

To evaluate the effects of dietary phospholipids on plasma lipoproteins in the postprandial phase six normolipidemic men were fed alternatively a test meal rich in phosphatidylcholine and a control meal low in phosphatidylcholine. Plasma very low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins were isolated at 2, 4 and 6 h after the meals. The changes in lipoprotein cholesterol, triacylglycerol, and phospholipid after feeding the phospholipid-rich meal were indistinguishable from those after the low-phospholipid meal. The phospholipid composition in high-density lipoproteins was also unchanged. The amount of phosphatidylcholine used in this trial was approximately 10-fold higher than that found in the normal Swedish diet. It is therefore concluded that the normal dietary intake of phosphatidylcholine has little influence on the plasma lipoprotein parameters measured in the present study.

Adult↗

Ethanol effects on bradykinin-stimulated phosphoinositide hydrolysis in NG 108-15 neuroblastoma-glioma cells.

The effect of short-and long-term ethanol exposure on bradykinin-stimulated hydrolysis of phosphatidylinositol 4.5-bisphosphate (PIP2) was investigated in neuroblastoma X glioma hybrid cells (NG 108-15). Acute exposure of 50-150 mM ethanol neither influenced the bradykinin-stimulated accumulation of [3H]-inositol phosphates (IP1, IP2, IP3) nor the hydrolysis of PIP2 in cells labelled with [3H]-inositol. Furthermore, ethanol (100 mM) added in the absence of agonist did not influence these parameters. However, in cells cultivated for 4 days in 100 mM ethanol, PIP2 hydrolysis and IP1, IP2 and IP3 formation after stimulation by 10(-6)-10(-5) M bradykinin was markedly inhibited while there was no effect on the basal levels or on the levels found after stimulation with low concentrations of bradykinin. The inhibitory effect of ethanol on IP accumulation became significant after 2-3 days of ethanol.

Bradykinin↗