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Biomedical subjects

P Six

Publications and source records attributed to P Six.

At least 19 recordsLinked to original sources

[Epidemiology of falls and hip fractures].

The risk of falling increases with age and with many of the disorders common in late life. Approximately 35 to 40% of community-dwelling people over the age of 65 and up to 50% of institutionalized elderly fall at least once every year. The incidence is highest in women and the very old. Hip fracture, one of the most serious injuries associated with falls, assumes epidemic proportions in old people. In addition to physical injury, falls can have other serious consequences for the older person. Repeated falls are a common reason for the admission of previously independent elderly persons to long-term care institutions. This article examines why older people fall and what factors place persons at risk for falling. The multiple reasons for an inconsistency of the epidemiological data are discussed.

Accidental Falls

[Approach to the rational management of patients with dementia].

In senile dementia the clinical presentation is not only determined by the mental deficits but also by affective, behavioral and somatic symptoms. Some sequelae are regularly associated with the process and the course of dementia, and therefore largely predictable and preventable. Identification of the complications commonly associated with this disease complex allows prevention and early treatment of states incriminating the natural course of the disease. By this approach a rational management of senile dementia can be achieved.

Activities of Daily Living

[Evaluating gait disorders in geriatrics].

Gait disorders in the elderly are a major cause of falls and accidents. They also interfere badly with the quality of life and the psychosocial well-being. The prevalence of these disorders is very high: 15% of the persons over 65 years and about 25% of those over 75 years suffer from gait disorders. The cause of gait disorders can be a specific disease, but in the elderly, multiple causes are much more frequent. In the elderly, the analysis of gait disorders consists not only of a diagnostic work-up, but also of a comprehensive geriatric and functional gait assessment. A minimal gait assessment includes a special clinical examination, an instrumental analysis of gait speed and a functional assessment of gait and balance by standard tests. In this article the relevant methods of a practical gait assessment are presented and some basic aspects of treatments are discussed.

Accidental Falls

[Lumbar spinal stenosis syndrome in the experience of a rheumatologic-geriatric clinic].

In the geriatric patient differential diagnosis of low back pain with sciatica includes degenerative lumbar spinal stenosis, affecting the central canal, the lateral recesses or both. Symptoms usually begin in the sixth decade, but may occur earlier if spinal degeneration is superimposed on congenital stenosis. In the elderly early diagnosis is more difficult to establish, because of the bewildering medical problems and the multiple symptoms rooted in the polypathy and polymorbidity of old age. Typical symptoms include low back pain, claudicatory pains, and paraesthesias of the legs, typically aggravated by standing and relieved by rest. In our series they were present in 100%, 94% and 56% respectively. In our series, the most important clinical investigations confirming diagnosis were pain provocation by reclining and pain relief by inclination (present in 69% of patients) and combined radiographic examination including plain films, computed tomography and myelography. In our experience myelography proved the best single method for early diagnosis. In our elderly patients lateral stenosis was predominant, and therefore lateral decompression by foraminotomy, generally combined with flavectomy, was the most important surgical procedure. In cases with combined lateral and central stenosis, hemilaminectomy or facetectomy was also performed. In follow-up 1 to 5 years after the operation the success rate, determined by very restrictive criteria, was 87%. Therefore, and because failure to establish early diagnosis potentially leads to definitive invalidity, degenerative lumbar spinal stenosis should be considered more frequently in the differential diagnosis of low back pain of the elderly.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged

[Diagnosis and therapy of hypotensive cardiovascular disorders in old age].

Postural hypotension, defined as a fall in systolic pressure of 20 mmHg or more on standing, and other hypotensive conditions are major problems in geriatric medicine. In this article the physiology and the pathology of orthostatic blood pressure regulation in the elderly are reviewed. Proposals are made for the diagnostic evaluation of patients with postural hypotension and for steps to be taken in therapeutic management.

Aged

Diagnostic value of reversibility of chronic airway obstruction to separate asthma from chronic bronchitis: a statistical approach.

Our aim was to assess the usefulness of tests of reversibility of airways obstruction (AO) in the differential diagnosis of asthma (A) and chronic bronchitis (CB). We selected on strict clinical criteria 20 CB and 32 A patients with stable AO and measured maximal forced expiratory flows before and after increasing doses of inhaled salbutamol. The highest sensitivity (Se), specificity (Sp) and likelihood ratio (L) were obtained when the improvement in forced expiratory volume in one second (FEV1) was expressed as a percentage of predicted FEV1. Se, Sp and L were 0.97, 0.95 and 19.3 (highest possible L: 20) for an increase of 10% of predicted FEV1 on 0.2 mg of salbutamol, and 1.0, 1.0 and 20, respectively, for an increase of 15% on 1 mg of salbutamol. Conversely, L was only 2.8 when the widely used increase in FEV1 of 20% over baseline was tested. In a second group of 42 unselected patients, who were referred to the laboratory for routine lung function testing with a presenting diagnosis of A or CB, L was only 5.5 when the 10% increase in predicted FEV1 was used and even lower for the classical 20% increase over baseline FEV1. We submit that routine tests of reversibility of AO have little diagnostic usefulness in unselected patients with AO and that the commonly used criteria of 15 or 20% increase in FEV1 over baseline are of no value in separating A from CB.

Albuterol

Chemical and enzymic degradations of nucleoside mono- and diphosphate sugars. I. Determination of the degradation rate during the glycosyltransferase assays.

In incorporation experiments used for the determination of glycosyltransferase activities, we demonstrated that the nucleoside diphosphate sugars are decomposed in three different ways: 1, transfer of the monosaccharide to acceptor molecule, catalyzed by glycosyltransferases; 2, degradation of the glycosyl nucleotides by nucleotide pyrophosphatase into monosaccharide 1-phosphates which are further hydrolyzed into free monosaccharides by phosphatases; 3, chemical decomposition of UDP-D-[14C]Gal; UDP-D-[14C]Glc and UDP-D-[14C]GlcUA into 1,2-cyclic phosphate derivatives of the corresponding monosaccharide. All the breakdown products of the nucleoside mono- and diphosphate sugars which are obtained during the incorporation experiments may be separated by paper chromatography and their amounts may be determined. Galactosyltransferase assays on human and rat serum have shown that the three different ways of decomposition of the nucleoside diphosphate sugars are dependent mostly on the concentration of divalent cations (Mn2+, Mg2+). Inhibition of the nucleotide pyrophosphatase activity is obtained with low concentrations of UMP, but increasing concentrations of UMP inhibit also the galactosyltransferase activity and consequently enhance the formation of galactose 1,2-monophosphate. A partial elimination of the nucleotide pyrophosphatase activity was achieved by the addition of increasing concentrations of UDP-D-Gal. These results demonstrate that the determination of glycosyltransferase activities in tissues and in biological fluids is not possible without a concomitant determination of the nucleotide pyrophosphatase activity present in the assay.

Adult

[Comparison of algorithms for the resolution of a secular equation in the vibrational analysis of biological molecules].

A computer analysis of several solution methods for secular equations leads to a determination of their optimum conditions. The results contribute to the application of a new preliminary method of frequency assignment to the vibrational study of the heavy atoms coordination sphere in complex biological structures, such as metalporphyrins and adenosine triphosphate.

Adenine Nucleotides

[Autoimmune polyendocrinopathy with IGA deficiency].

Case report of a 35-year-old female patient who was admitted in Addisonian crisis and in whom primary adrenal, ovarian and thyroid failure was detected. Antibodies against the adrenals and the thyroid were found, together with dinished serum IgA levels. The patient had been treated for 20 years with diphenylhydantoin, a drug known to induce immunological disturbances, e.g. depression of serum IgA levels. The IgA deficiency and pluriglandular failure may be due to prolonged therapy with diphenylhydantoin. The coincidence of IgA deficiency and autoimmune diseases is well known. As far as is known this is the first case of IgA deficiency associated with autoimmune polyendocrinopathy.

Addison Disease

[Piribedil, dopaminergic agonist. Prolonged clinical and electrophysiological study in 60 parkinsonian patients (author's transl)].

Sixty cases of Parkinson's disease were treated with piribedil alone (dose : 274 mg/day, duration : 20,4 months). The overall clinical improvement, confirmed by recordings of tremor and EMG, was 34%, tremor being improved of 59%. Before treatment, an intravenous test does of piribedil with recording made it possible to predict the effectiveness of oral treatment. Side-effects (vasomotor, digestive, psychiatric) were moderate. Orthostatic hypotension, dyskinesia and fluctuations were exceptional. The basic indication for piribedil lies in forms of recent onset in which tremor predominates, patients in whom L-dopa is contraindicated and a certain number in whom the latter has failed (tremor, fluctuating action).

Administration, Oral

[Thiamine, riboflavine and pyridoxine supply in chronic alcoholism (author's transl)].

Tests on 50 chronic alcoholics demonstrated that there was a reduced supply of thiamine (measured with the transketolase activation test) and riboflavine (glutathione reductase test) compared with results obtained in 1152 healthy controls. A high risk of thiamine deficiency was present in 45.4% of male and 50% of female alcoholics; risk of riboflavine deficiency was 11.1% and 16.7%, respectively. Corresponding results in the normal controls were 2% for thiamine and 0.4% for riboflavine deficiency. There was a significant relationship between enzymatic values of thiamine deficiency, on the one hand, and anaemia, abnormal liver functions (bilirubin, gamma-globulin) and low diastolic arterial pressure, on the other. Enzymatic riboflavine values also correlated with haemoglobin content, so that it is assumed that the anaemia is associated with the reduced thiamine or riboflavine supply. Enzymatic determination of pyridoxine with the GOT activation test would seem to be influenced by alcohol or by metabolic processes induced by it and is therefore not suitable in the presence of chronic alcoholism.

Adolescent

Interaction study between phenprocoumon and flurbiprofen.

The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of 2 weeks. The last control followed 1 week after cessation of flurbiprofen. All changes observed during the administration of flurbiprofen were quantitatively moderate; some reached statistical significance. The prothrombin time (%) Factor II and Factor X values fell; Factor II values remained unchanged. Factor IX values fell only in the first week on flurbiprofen and reached control values thereafter. Phenprocoumon concentration remained constant throughout. There was no change in spontaneous platelet aggregation. Although there was a slight, statistically significant increase in the Ivy bleeding time, it remained within the normal range. These findings suggest that the interference of flurbiprofen with oral anticoagulation is minimal and probably of no clinical relevance.

4-Hydroxycoumarins