Biomedical subjects

P Skłodowski

Publications and source records attributed to P Skłodowski.

5 recordsLinked to original sources

PubMed1999

[Night headache: report of 2 cases].

The pathogenesis of hypnic headache is still unknown. Some authors supposed that the genesis of hypnic disorder is a decrease of melatonin secretion. It is a rare, moderately severe headache that occurs in middle-aged or elderly patients and affects both sexes. It appears exclusively during sleep and often with alarm clock regularity. The attack lasts from two to 6 hours, it may be unilateral or diffuse, pulsating or boring, without autonomic system features. Case 1. A 49 year old man reported the history of two week nocturnal headache that awakened him every night from sleep. The headache lasted two hours. There were no autonomic system features. Case 2. A 52 year old man suffered from nocturnal headaches for 6 weeks. The pain occurred between 2 and 5 almost every night and woke the patient. He suffered from diabetes mellitus too. Both patients were treated with flunarizine with good results.

Circadian Rhythm↗

PubMed1995

Creutzfeldt-Jakob disease: ultrastructural study of brain biopsy: unusual interaction between astrocytes and oligo- and microglia.

We report a case of Creutzfeldt-Jakob (CJD) disease in a 72-year-old man without characteristic EEG alterations. Unusually abundant pleomorphic PrP-immunopositive amyloid plaques were found in the cerebellum. Despite of this similarity with Gerstmann-Străussler-Scheinker (GSS) disease the case cannot be classified as GSS lacking classical GSS 102 PRNP gene mutation. The ultrastructural findings were similar to those described previously for CJD. The close contact of reactive astrocytes with both oligodendroglia and microglia in this case suggests their possible functional interaction.

Aged↗

PubMedDate not supplied

[Familial dystonia: a case of idiopathic torsion dystonia].

A 43 year old man suffered from the involuntary movements since 10-th year of age. Those movements, initially mild, have progressed in the course of the disease. In the neurological examination the dystonic involuntary movements of the neck, trunk and limbs, more expressed on the right side, were observed. The laboratory findings were normal, except the level of dopamine beta-hydroxylase, which was increased. Similar results were observed also in the closest relatives of our patient. After the treatment with high doses of L-Dopa we achieved a considerable decrease of the symptoms.

Adult↗

PubMedDate not supplied

[SUNCT syndrome--case report].

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tears (SUNCT) syndrome is a very rare disorder, first described by Sjaastad et al. in 1989. The authors report a case of that type of headache in an 80 years old woman. They also discuss the pathophysiology and treatment.

Aged↗

PubMedDate not supplied

[Critical opinions on the treatment of multiple sclerosis with immunosuppressive agents].

The author reviews some important publications dealing with treatment of multiple sclerosis (m.s.) with the most commonly used immunosuppressive agents i.e. steroids and cyclophosphamide. He emphasises the methodology referring to group selection as well as placebo group and the way of the therapy results verification. The author concludes that many studies on the effective treatment with immunosuppressive agents are not sufficiently proved from the methodological point of view as well as the evaluation of the therapeutical effects in comparison with the placebo group is not convincing. The author appreciates the use of MRI in evaluation of the treatment effects. In the authors opinion the effectiveness of immunosuppressive therapy has not been so far sufficiently proved.

Adrenocorticotropic Hormone↗