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Biomedical subjects

P Skinhöj

Publications and source records attributed to P Skinhöj.

6 recordsLinked to original sources
PubMed1989

A randomized trial of oral versus intravenous acyclovir for treatment of herpes zoster in bone marrow transplant recipients. Nordic Bone Marrow Transplant Group.

Twenty-seven bone marrow transplant patients who developed localized herpes zoster were treated with acyclovir in a randomized study comparing oral and intravenous drug administration. Fourteen patients received oral and 13 patients received intravenous treatment. None of the patients developed disseminated disease. No differences were found between the treatment groups in the number of days that new lesions continued to develop, in number of days with pain, or in the number of days from start of treatment until all lesions were crusted over. We suggest that oral acyclovir may be as effective as intravenous acyclovir in the treatment of localized herpes zoster after bone marrow transplantation.

Acyclovir↗
PubMed1977

Serological evidence of hepatitis B infection in patients with chronic liver diseases: radioimmunoassay of HBsAg and anti-HBs.

The prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs was determined by a sensitive double-antibody radio-immunoassay technique in a series of patients with chronic liver diseases. HBsAg was demonstrated in 37 out of 98 consecutive patients with chronic hepatitis (38%) and in 14 out of 108 patients with non-alcoholic cirrhosis (13%). HBsAg was not found in any of the patients with steatosis, alcoholic cirrhosis, or primary biliary cirrhosis. In the patients with chronic hepatitis HBsAg or anti-HBs was demonstrated in 83% of the patients below 40 years of age in contrast to 48% of the patients more than 40 years of age. It is concluded that a substantial part of the patients with chronic hepatitis has serological evidence of actual or past hepatitis B virus infection. This is in contrast to the groups of patients with other chronic liver diseases.

Alcoholism↗
PubMed1977

Humoral and cell-mediated immunity to hepatitis B virus antigens in acute and chronic liver disease.

The humoral immune response to hepatitis B virus antigens and the cell-mediated immunity to hepatitis B surface antigen (HBsAg) were investigated in 12 healthy persons and 56 patients with various liver diseases. In patients with acute viral hepatitis type B, anti-hepatitis B core antigen was present constantly in serum in all phases, and after clinical recovery simultaneously with anti-HBs. A transitory cellular immune response to HBsAg was demonstrated at the time the antigen was cleared, while a patient with persisting HBs antigenaemia and another with transient hepatitis Bc antigen showed no response during the course of the disease. Cellular immune response to HBsAg was present only infrequently in patients with chronic liver disease type B and non-B, thus suggesting that a cellular immunity to HBsAg is not a prerequisite for the development of these conditions.

Acute Disease↗