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Biomedical subjects

P Sobotka

Publications and source records attributed to P Sobotka.

At least 19 recordsLinked to original sources
PubMed1992

Nutrition in acute pulmonary disease.

Acutely stressed patients with chronic pulmonary disease have a particular need for accurate nutritional assessment and appropriate nutritional therapy. Loss of skeletal muscle, often extensive, can be paralleled by dramatic alterations in cellular function; inadvertent provision of excessive calories or of individual substrates may produce more harm than benefit. In the absence of a single "gold standard" for nutritional assessment and monitoring, no single value should take precedence over the entire clinical picture, which should be thoughtfully assessed and reassessed, with both the patient's nutritional needs and the consequences of their provision kept in mind. In the future, assessments of the impact of nutritional intervention will probably rely more heavily on functional tests of specific organs and of the immune system. Intervention will be based not only on provision of calories, individual substrates, vitamins, and minerals, but also on control of the inflammatory response in order that the nutrients may be properly utilized.

Acute Disease↗
PubMed1981

Electrocorticographic activity induced by gamma hydroxybutyrate in the rat during ontogenesis.

GHB at a dose of 200 mg . kg-1 i.p. elicited groups of slow waves with a frequency of 4--5 Hz in both frontal and occipital ECoG leads in adult rats. In 25- an 18-day-old rats similar slow wave activity became continuous and exhibited a clear-cut maximum in the frontal regions. In 15- and 12-day-old animals slow wave activity was also registered in the frontal region but it was organized into short groups of unstable frequency. No ECoG effects of GHB could be found in 9-day-old rats.

Aging↗