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Biomedical subjects

P Soichot

Publications and source records attributed to P Soichot.

At least 19 recordsLinked to original sources

Cancellation of single F wave by double stimulation in case of chronic denervation.

Single F waves evoked by stimulation with above threshold intensity are cancelled by a second shock, as was previously demonstrated with maximal or sub-maximal intensity. Double stimulation of any intensity thus makes it possible to detect a possible reflex component in the spinal response, by elimination of the F wave. As an H or a heteronymous H reflex may be a sign of a disordered central motor system state, this fast method has a direct clinical utility.

Adult

[Value of gadolinium magnetic resonance imaging of the lumbosacral roots in acute polyradiculoneuritis].

Four patients with acute inflammatory polyradiculoneuropathy were evaluated with MRI. In 3 of 4 cases, gadolinium enhancement was observed in the nerve roots of cauda equina, on frontal and horizontal slices. This enhancement was correlated with the severity of the clinical picture and the cerebrospinal-fluid inflammatory protein concentration and supports the inflammatory nature of this forms of acute polyradiculoneuropathy.

Acute Disease

[Electrophysiologic data on myasthenic syndromes of the Lambert-Eaton type. A series of 23 cases].

The electrophysiological data of 23 adult patients with Lambert-Eaton myasthenic syndrome (LEMS) have been reviewed. Lung carcinoma was disclosed in 17. In six cases with an EMG follow-up ranging between one and 17 years no carcinoma was detected. The results of repetitive nerve stimulation test (RNS) were not statistically different between the 2 groups. Low CMAP ulnar amplitude was present in all patients (mean: 1.7 mV). Decremental response at low rate of stimulation (3 Hz) was present in 17/20 (means: 30%). An abnormal incremental response at high rate of stimulation was present in all cases (mean: 826%). The authors emphasize the interest of a 50 Hz stimulation for 4 s. Increase of the 'F-wave' amplitude was noticed in some cases. Electrophysiological changes suggestive of an associated mild neuropathy were noticed in eight patients but H-reflex was present in 3/3 cases. SFEMG abnormalities were found in 6/6 cases. In one case, stimulated SFEMG showed more blockings and an increased jitter with low rate of stimulation. In one case the electrical pattern of RNS could be misinterpreted as myasthenia gravis in one tested muscle only. The author's results suggest that CMAP amplitude and RNS test could be used to appreciate the short-term improvement of LEMS with treatment and in some cases for the long-term follow-up.

Adult

[Investigation via electroencephalogram with sphenoidal electrodes of a case of reading epilepsy: role of the temporal lobe in the emotional evocation of seizures].

Reading epilepsy in a 20-year-old male. Electroencephalographic study with sphenoidal electrodes localized the onset of critical spikes in the temporal areas (especially the left). The frequency and diffusion of critical spikes were increased when material read had an emotional content. This case report supports the "communication" hypothesis as opposed to hypotheses that emphasize proprioceptive and other "lower order" stimuli in evoking seizures while reading. The authors discuss the role of the temporal lobe in reading: lexical function, treatment of visual information and emotional integration of stimuli.

Adult

[EEG periodic lateralized activities associated with ischemic cerebro-vascular strokes: physiopathologic significance and localizing value].

Eleven cases of periodic lateralized epileptiform discharges (PLED) with stroke (9 cases) or transient ischemic attacks are reported. PLEDs are often associated with depression of conscience (81%) or partial pure motor epileptic seizures (90%). PLEDs and seizures seem independent on EEG. Ischemic strokes associated with PLEDs have some characteristic features: old age, vascular risk factors, parieto-occipital areas infarcts and frequent association with TIAs. PLEDs seem to be often associated with watershed infarcts. The relations between PLEDs and cerebral ischemia are discussed.

Aged

[Electrophysiologic investigation of the anterior temporal and frontal lobes: sphenoidal and intraorbital electrodes].

The authors have evaluated the interest of sphenoidal electrodes in detection of internal temporal spikes, and intra-orbital electrodes in the detection of orbito-frontal spikes. From a study of 26 patients, 21 with sphenoidal electrodes, 3 with intra-orbital electrodes and 2 with both electrodes, they observed the sensitivity and specificity of such electrodes in detecting spikes with no traduction upon extra-cranial electrodes, or with an unsuspected traduction as spikes at a distance from deep electrodes, or spikes on 2 foci, or bisynchronous discharges. Sphenoidal and intra-oribital electrodes constitute a non-invasive method that provides excellent information in the exploration of the mesiobasal cerebral face. Indications for the use of such a method are complex absences without EEG traduction or with an unsuspected traduction and without abnormalities on CT scan, in the context of functional surgery of epilepsy.

Adolescent

[Identification of temporal epileptic seizures using percutaneous sphenoidal electrodes].

The authors have evaluated the indications, methods and results of sphenoidal electrodes in epilepsy. This method makes it possible to study the hippocampal area which cannot be studied by extracranial electrodes. It also localizes in a temporal lobe complex seizures without electrical events, or complex seizures giving bilateral temporal spikes or a fronto-temporal focus of spikes. It may even show evidence of temporal focus in cases with bilateral and synchronous spikes. Thus, sphenoidal electrodes enable temporal seizures to be identified and localized, leading to more specific neuroradiological explorations and therefore helping in the selection of patients for specific surgery.

Adolescent

[Local complications after axillary block anesthesia].

The authors treated a local complication after axillary block, probably after intraneural injection of lidocaine. At the operation severe epineural fibrosis was found and released. The result was good after some months. After this the authors realized a study with 14 hand surgeons, and only few cases like the first case were found. This technique axillary block, is very reliable technique, but very few local complications can occur, and it's necessary to know them. It's possible to avoid this local problem with a serious technique to realize axillary block. Never intraneural injection and never many punctures to research paresthesia from the nerves of the brachial plexus.

Adult

[Familial benign neonatal seizures: EEG, clinical, prognosis and genetic features].

The authors describe 3 families in which several members presented convulsions exclusively during the neonatal period. The EEG and clinical findings showed typical short neonatal convulsions lasting several months and with no apparent etiology. The dominantly inherited transmission is certain. Prognosis is very good, although 14% of the cases in the literature present an onset of epilepsy after 20 years of age. Even though this phenomenon is unusual, the rarity of its description probably stems from lack of knowledge rather than low incidence. We thus would like to show that, even in the neonatal period, familial epilepsy can occur.

Female

[Elevation of gamma-glutamyltransferase levels in treated epileptic patients].

Plasma levels of gamma-glutamyl transpeptidase were measured prospectively in 75 epileptic patients treated with one of the following drugs: phenobarbitone (n = 20), phenytoin (n = 23), carbamazepine (n = 18) or sodium valproate (n = 14). A significant increase in gamma-glutamyl transpeptidase levels was observed from the 7th day of treatment onward. The increase was particularly pronounced in the phenytoin group, with mean and maximum values of 104.10 and 215 mU/ml respectively, followed by the phenobarbitone group (mean 68.15, max. 124 mU/ml), the carbamazepine group (mean 49.83, max. 100 mU/ml) and the sodium valproate group (mean 35.42, max. 70 mU/ml). This was due to enzyme induction being highest with phenytoin and phenobarbitone which are strongly liposoluble and have prolonged half-life. Any epileptic patient with plasma gamma-glutamyl transpeptidase levels higher than those found in this study may be suspected of having viral or alcoholic hepatitis.

Adult

[Orthostatic arterial hypotension and giant aneurysm of the basilar trunk].

The authors report two observations of giant aneurysm of basilar artery, where the first neurological signs were preceded or escorted by a postural hypotension. They emphasize the place of rhombencephon in the control of blood pressure and they bring together their cases with those reporting a postural hypotension revealing a lesion of medulla. They insist upon the necessity to look a peripheric and central neurological lesion in front of a postural hypotension.

Adult

[Rare cause of myoclonus with giant SEP's: methyl bromide poisoning. Apropos of a case with unilateral predominance].

Giant and asymmetric SEPs were recorded in a patient with predominantly unilateral, spontaneous and intention myoclonus due to voluntary intoxication with methyl bromide as soon as day 3 after intoxication. The N10 Erb's point potential, cervical N13 and scalp recorded P15 potentials were found to be normal in latency, morphology and amplitude. The somesthetic informations could be considered as normally processed up to the subcortical levels of the somatosensory pathways. The parietal cortical potentials N20 and P25 and the frontal cortical potentials P22 and N30, contralateral to myoclonus, were abnormally large. This suggests that myoclonus could be related with an abnormal reactivity of somatomotor and somatosensory cortices to the afferent volleys triggered by voluntary movements. The prerolandic components P22 and N30 were found to be relatively more enhanced than the parietal N20 and P15.

Cerebral Cortex

[Evaluation of changes in gamma-glutamyltransferase in chronic treatment with antiepileptic agents].

To know the intensity of liver enzyme induction during a treatment with anticonvulsant, the authors have measured gamma GT before and at the 7th, 30th, 60th days after a treatment by one of the 4 major anticonvulsant as phenobarbital, diphenylhydantoin, carbamazepine and sodium valproate. All alcoholic patients, and all the patients having a liver disease have been eliminated. The results show that diphenylhydantoin is the most important inductor of gamma GT with an elevation that can reach 312% of basal level, followed by phenobarbital, when sodium valproate and carbamazepine are the weakest inductors. More, induction by carbamazepine in women is more weak than in man. Age takes a place in intensity of induction with a major induction observed between 30 and 50 years old for phenobarbital, and above 50 years old for sodium valproate. These effects are not dependent of an hepatitis. The knowledge of the upper levels of gamma GT induction by anticonvulsant appear to us usefull for several reasons: carbamazepine and sodium valproate being the weakest inductors, they must be chosen in priority in women under contraceptive treatment. Any abnormal elevation of gamma GT need to look of an alcoholic intoxication, an hepatitis or a liver cancer.

Adult

[A unusual manifestation of multiple sclerosis: sciatica].

The authors recall the possibility of a typical sciatica in multiple sclerosis and describe seven new cases. Their main clinical features are: early onset before any other signs of the disease, hyperalgic, paroxysmal, short, repetitive episodes, absence of mechanical or effort triggers, absence of improvement with rest or anti-inflammatory drugs, well defined course. The intra-medullar origin of these attacks is suggested by the clinical criteria and the aspect of evoked potentials of the lower limbs recorded in 2 of the 7 patients.

Adult

[Mental confusion in childhood migraine].

From 3 cases reports, the authors emphasize the importance of acute confusional migraine in childhood. It is more frequent than in adulthood and it is often the presenting problem making the diagnosis more difficult.

Child