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Biomedical subjects

P Spieler

Publications and source records attributed to P Spieler.

23 records · Page 2Linked to original sources
PubMed1976

[Evaluation and significance of cholesterol containing abdominal fluid].

In 2 female patients with clinical suspicion of malignant abdominal tumor "ascitic" fluid obtained by abdominal paracentesis, was found to contain an abundant amount of cholesterol. Laparotomy revealed huge, benign ovarian mucinous cystadenomas. The cytological diagnosis of cholesterol-containing cystic fluid is discussed. Cholesterol-containing cystic fluid is discussed. Cholesterol-containing cystic fluids can be differentiated cytologocally from serous and chylous effusions, and also from cholesterol pleurisy and cholesterol peritonitis.

Ascitic Fluid↗
PubMed1976

Evaluation of prostatic cytology in primary diagnosis and clinical course of prostatic carcinoma.

Franzén's method of transrectal aspiration biopsy, capable of being performed without narcosis or hospitalization of the patient, is an ideal method of early recognition of prostatic carcinoma, and its reliability is equal to the more elaborate transrectal or transperineal needle biopsy. For the appraisal of the local therapy-effect, transrectal aspiration biopsy can be successfully used if no high-voltage radiation treatment of the primary tumour has been administered. For local progress-checks on radiologically treated prostatic carcinomas, however, needle biopsy with the Tru-Cut needle is clearly superior to aspiration biopsy. Cytologic and histologic progress-checks reveal that the local therapy-effect of the measures were applied were directly dependent on the primary degree of differentiation. No improvement in the therapy-effect is to be achieved by the use of high-voltage radiation, especially in cases of undifferentiated carcinoma of the prostate. The clinical course is also largely determined by the primary degree of differentiation, and 20 % of stage C patients tend, with or without radiation-treatment, to rapid metastasisation, although the local tumour may have partically disappeared after such treatment. The plasmatestosterone level could be related neither to the local therapy-effect nor to the clinical course, whereas the enzyme-status in numerous cases coincided with the clinical history, though not with the cytologically or histologically determined therapy-effect. We could not establish any radiologically induced typical therapy-effect on the prostatic carcinoma either by cytological or histologic means.

Acid Phosphatase↗
PubMedDate not supplied

The cytologic diagnosis of tuberculosis in pleural effusions.

This paper reports on eight patients who had cytologic findings suggestive of florid pleural tuberculosis in pleural exudates. The suggestive diagnosis in each case was confirmed either by a pleural biopsy, culture of Mycobacterium tuberculosis from the aspirated fluids or clinical improvement from the administration of tuberculotherapy. The pleural effusion from tuberculosis is characterized by the presence of abundant lymphocytes in the smear. The nuclei of the lymphocytes show characteristic morphologic features. The two most important differential diagnoses are those effusions rich in lymphocytes due to nonspecific causes and effusions containing numerous tumor cells from a well-differentiated lymphosarcoma.

Adolescent↗
PubMedDate not supplied

Identification of types and primary sites of malignant tumors by examination of exfoliated tumor cells in serous fluids. Comparison with the diagnostic accuracy on small histologic biopsies.

The accuracy of identification of tumor type and primary site of malignant tumors by examination of exfoliated tumor cells was cytologically studied in 448 malignant effusions from 366 patients for whom the primary tumor site had been confirmed by histology. Ninety-seven corresponding small biopsies from metastases were separately reviewed histopathologically. In four fluids, the cells were too scanty or too poorly preserved for tumor typing. The cytologic tumor typing was performed with nearly 100% accuracy in the remaining 444 fluids, except for those of intermediate-cell anaplastic carcinomas (0 of 3) and poorly differentiated squamous (epidermoid) carcinomas (1 of 5). Adenocarcinoma was correctly identified in 98% of 285 fluids, large-cell carcinoma in 97% of 108 fluids, oat-cell carcinoma in 94% of 16 fluids, well-differentiated (keratinizing) squamous carcinoma in 100% of 3 fluids, malignant lymphoma in 100% of 22 fluids and sarcoma in 100% of 2 fluids. The criteria and the failures are discussed at length. In the investigation of the accuracy of cytologic and histologic diagnoses with respect to the primary tumor site, tumors with variable sites of origin (sarcomas and lymphomas) and those with usually singular sites of origin (e.g., small-cell anaplastic carcinoma of the lung) were excluded, leaving 387 cytologic and 83 histologic specimens available for review. The breast as a primary site was correctly identified in 70% of both the cytologic and histologic specimens; the primary cytodiagnostic criteria included a uniform cell pattern, finely granular chromatin, dense cytoplasm and cell balls with smooth borders. Ovarian primaries were correctly identified in 70% of the fluids and 83% of the biopsy samples on the basis of very irregular clusters of large pleomorphic tumor cells, large nucleoli and psammoma bodies. Lung primaries, identified in 50% of the fluids and 29% of the biopsy samples, showed quite variable cell patterns, most often including large pleomorphic cells with or without mucus formation and prominent multinucleation. Gastric cancers of the diffuse type were accurately identified in 52% of the corresponding fluids, which showed mainly isolated cells with dense cytoplasmic rims, occasional signet-ring cells, "embryo-shaped" nuclei, marked hyperchromasia and densely granular chromatin.(ABSTRACT TRUNCATED AT 400 WORDS)

Adenocarcinoma↗