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Biomedical subjects

P Stoicescu

Publications and source records attributed to P Stoicescu.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[The pulmonary manifestations in AIDS].

Clinical and paraclinical experience in HIV infection, though the time elapsed since the first observations is relatively short, begins to get typical outlines. In the case of AIDS, the lung is the main place of opportunistic infections, other inflammatory processes and neoplasia. The present work deals with six clinical cases with positive serum tests for HIV and secondary respiratory phenomena such as: Kaposi sarcoma, pneumonia with Pneumocystis carinii, tuberculosis, candidosis, pneumonia with common germs. Particular aspects of treatment and disease evolution are commented.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[The respiratory manifestations in the picture of phakomatosis].

After a short review of phakomatosis nosology, the paper deals with 3 clinical cases, out of which two of Recklinghausen neurofibromatosis and one of tuberous sclerosis (Bourneville's disease), all of them with pulmonary determinations, confirmed bioptically and histopathologically. A "florid" cutaneous syndrome (including all the variants of skin lesions) dating from childhood, subsequently accompanied by phenomena of psychical involution and behaviour troubles were present in two cases; retinal lesions were also associated in the third case. Visceral intrapulmonary determinations (i.e. diffuse interstitial fibrosis, and even bronchopulmonary neoplasm in one case) were registered in all cases, too. The diagnostic importance of investigating all apparatus, systems and organs which can be jointly involved in phakomatosis is emphasized. The importance of an inquiry regarding family history is also noticed. For the studied cases, the contribution of complementary (psycho-neurological, ophthalmological, orthopaedic a.s.o.) examinations--though quite valuable--took a back seat in comparison with the essential elements provided by the dermatological and histopathological examinations.

Biopsy↗
PubMedDate not supplied

Histologic aspects in pleural diseases revealed by needle biopsy.

In 59 patients, 18 to 82 years old, with pleural exudates, a number of 78 needle biopsies were performed in view of establishing the etiologic diagnosis. The diagnosis was: pleural tuberculosis in 9 cases, acute or chronic non-tuberculous inflammation in 8 cases, postinfectious sequelae in 6 cases, secondary malignant neoplasia in 10 cases; 2 mesotheliomas, and in 24 cases the aspect was normal or the minimal alterations found were not conclusive. The proportion of confirmations was of 81% for tuberculosis and 37% for cancer. The method is recommended as being of particular value in establishing the etiologic diagnosis of pleural exudates.

Biopsy, Needle↗
PubMedDate not supplied

[Pulmonary involvement in scleroderma].

The paper deals with 3 cases of sclerodermia with pulmonary determinations detected by clinical, radiological, functional and histopathological means, of diffuse interstitial fibrosis type. The association with bronchopulmonary cancer is pointed out in one case only.

Adenocarcinoma↗
PubMedDate not supplied

[The therapeutic prospects of patients with bronchopulmonary cancer].

By means of a retrospective analysis on 405 cases found out as having bronchopulmonary cancer, the therapeutical possibilities on fixing the diagnosis were evaluated. The therapeutical attitude indicated by pre-established criteria and the therapeutical line adopted were also analysed. The low percentage (25%) of cases with favourable therapeutical perspectives at case finding, as well as the high percentage (75%) of cases found out in stages therapeutically beyond treatment are pointed out. Several non-concordances between recommended and applied therapies are discussed.

Adult↗
PubMedDate not supplied

Clinical management of bronchial asthma with inhaled high-dose beclomethasone dipropionate (Beclomet 250--Orion).

The efficacy of inhaled high-dose beclomethasone dipropionate (BDP) in intrinsic and cortico-dependent asthma was studied in 12 asthmatics (3 males and 9 females), average age 39 years (range 17-62 years), with a mean duration of the disease of 9 years (range 2-20 years). The patients were instructed to use one actuation (250 micrograms), three times daily or two actuations three times daily in severe cases in which dyspnoea persisted during the intake of oral corticosteroids. The results during the 6 month follow-up period were: Clinical: dyspnoea, wheeze and cough disappeared or diminished, oral administration of corticosteroids stopped or the daily dose was reduced, the intake of beta-agonists decreased; Functional: after 2-4 weeks, in almost all cases, the base line values of FEV 1.0 and Raw were normal and hyperinflation significantly diminished after the first month of BDP therapy. Clinical and functional improvement were maintained during the follow-up period; no side-effects were revealed.

Administration, Inhalation↗
PubMedDate not supplied

[Computed tomography in establishing the therapeutic management of lung cancer].

Computer tomography (CT), a noninvasive method of high complexity, compelled recognition in pneumological practice, becoming indispensable. The present study deals with 59 patients suspected of bronchopulmonary cancer, who were submitted to computer tomography, besides other examinations. CT contribution in establishing the diagnosis, the therapeutical line (particularly in determining the surgery moment) as well as the correlations (concordance and discordance) between the information offered by CT and by other conventional (radiological, bronchological) methods are analysed. The association of thin needle trans-thoracic biopsy (TNB) to CT ensures an important histologic confirmation which amounts to 75% of investigated cases, according to our statistical data.

Adolescent↗
PubMedDate not supplied

[Mediastinal-pulmonary lymphangioleiomyomatosis. The anatomicoclinical aspects].

The lymphangioleiomyomatosis is a rare disease which has a severe course and prognosis and occurs exclusively in females. The symptomatology is not characteristic and the radiological picture is that of a reticular and micronodular diffuse interstitial process. The morphological examination is the only which elucidates the diagnosis. Two cases are reported, the diagnosis of which was established postmortem. In the first case, the site was predominantly pulmonary; in the second case, in addition to the lung, the mediastinal lymph system was also strongly damaged. The morphological changes are characterized by an abnormal proliferation of muscular tissue at the level of the pulmonary interstitium and of the pulmonary and mediastinal lymphatics. The process develops towards destructive lesions of the bronchiolo-alveolar and vascular structures. The pathogenesis is unknown, but genetic and endocrine factors seem to be involved.

Female↗
PubMedDate not supplied

[Value of methods used in the etiological diagnosis of pleural exudates].

A study was carried out on 64 cases of pleural exsudates, i.e. 23 of neoplastic origin, 13 tuberculous, 10 with various etiologies and 8 the cause of which could not be determined. In all cases pleural biopsy puncture was performed, once or several times, the histologic examination confirming 80% of the cases of tuberculosis and 40% of the cancer cases. Biochemical methods are orientative, their significance increasing when the other probability tests give convergent results.

Glucose↗