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Biomedical subjects

P Sträuli

Publications and source records attributed to P Sträuli.

At least 55 records · Page 3Linked to original sources
PubMed1977

The spread of cancer in the organism. Facts and problems.

In this review, cancer is conceived as an alteration of the suface-monitored social behavior of cells. Apart from impaired growth controls, loss of residency (tissue affiliation) is the most important consequence of this homeostatic disorder. It results in local spread (penetration) which is initiated by locomotive and/or desctructive activities of the neoplastic cells. Access of cancer elements to the circulation possibly leads to distant spread (metastasis). Penetration and metastasis largely depend upon reactions of the organism, which are of an ill-understood, ambiguous nature favoring both the tumor and the host.

Animals↗
PubMed1976

Motility of l5222 rat leukemia cells.

The locomotive behavior of cells of the transplantable rat leukemia L5222 was studied by means of microcinematography. It was found that these cells exhibit a homogeneous pattern of movement resembling that of normal lymphoblasts and stimulated lymphocytes. This is in contrast to cytochemical and ultrastructural evidence according to which the cells are completely undifferentiated. Another phenomenon, recorded by timelapse, is the ability of the cells to move in a spherical and in a flattened state. Treatment with cytochalasin B in a concentration of 30mug/ml leads to loss of locomotion. Incubation with colchicine, 40mug/ml, results in a greatly reduced locomotion, while the on-spot motility is not impaired. The suitability of this model for investigations on the role of locomotion in penetration and tumor cell dissemination is emphasized.

Animals↗
PubMed1975

Penetration of an ascitic reticulum cell sarcoma of the golden hampster into the body wall and through the diaphragm. A scanning electron microscopic (SEM) study.

SEM studies on infiltration of the ascitic form of the hamster reticulum cell sarcoma HaTu 25 into the ventral body wall and through the diaphragm were performed during 6 consecutive days after intraperitoneal transplantation. The findings allow an interpretation of the course of events based on 3 main stages: 1) Contraction of mesothelial cells with partial exposure of the submesothelial stratum. 2) Preferential attachment of tumor cells to these denuded areas. 3) Advance of tumor cells within defects gradually extening from the submesothelial stratum of the musculature. These stages were more pronounced and took a more rapid course at the peritoneal side of the diaphragm than at the body wall. At the pleural side of the diaphragm the appearance of single tumor cells within widened intercellular spaces of the mesothelium was recorded prior to the onset of penetration at the peritoneal surface. The rapid migration of tumor cells through the diaphragm as well as the particularly intensive tumor infiltration into this organ is thought to be connected with the mechanism of intravasation of tumor cells into the lymphatic plexus of the diaphragm. During the whole sequence of events, HaTu 25 cells were found to have maintained their spherical configuration and characteristic surface architecture. Apparently, growth pressure is of minor or no importance in this spacial mode of tumor penetration, rather the action of proteolytic enzymes elaborated by the tumor cells has to be taken into consideration.

Abdominal Muscles↗