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Biomedical subjects

P Strömberg

Publications and source records attributed to P Strömberg.

9 recordsLinked to original sources
PubMed1989

Comparison of ketoprofen and naproxen in the treatment of dysmenorrhoea, with special regard to the time of onset of pain relief.

In a double-blind, crossover study in 39 women with dysmenorrhoea, the effects of oral treatment with single doses of 100 mg ketoprofen and 500 mg naproxen were compared with regard to time for onset of pain relief and overall effect on symptoms. Assessments of pain severity using a visual analogue scale and an activity-related scale were made at 15-minute intervals for 2.5 hours. The results showed that ketoprofen was significantly more effective at 60 and 45 minutes, respectively, after intake of medicine and the differences remained significant until 120 and 105 minutes, respectively. Reduction in original pain by 50%, the patient's view on the overall effect after each treatment as well as a comparison of effects at the end of the study all differed significantly in favour of ketoprofen. No significant differences were found between treatments in the need for additional analgesic therapy after the 2-hour observation period or in the incidence of side-effects, which was low with both medications. It is suggested that ketoprofen could have a therapeutic advantage over naproxen, particularly in patients in whom menstrual pain develops rapidly.

Adolescent↗
PubMed1987

Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study.

A competitive inhibitor of the action of oxytocin on the uterus, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, was studied for the first time in 13 patients with established, uncomplicated premature labour. Intravenous infusion of 10-100 micrograms/min of the analogue was given for 1-10 h and the effect was monitored by external cardiotocography. In all women an inhibition of uterine activity was observed, and in the majority of patients infused with 25 micrograms/min and a total dose of about 5 mg or more of the drug total inhibition of uterine contractions was achieved. There were no effects on the maternal and fetal pulse rates, nor were there any other side-effects. The results of this preliminary study support the concept of an increased concentration of uterine oxytocin receptors being aetiologically important in uncomplicated premature labour. They also suggest that the present oxytocin antagonist could be an interesting therapeutic alternative in the condition, primarily because of the marked selectivity of its effect.

Clinical Trials as Topic↗
PubMed1979

Fetoscopy.

A brief report is given on fetal blood sampling by fetoscopy in three fetuses at risk for severe congenital bleeding disorder; hemophilia A in two cases, von Willebrand's disease in one. Published reports on complications of fetoscopy are reviewed. Out of all together about one hundred pregnancies that have been allowed to continue after fetoscopy, five ended in miscarriage. No other serious complication has been reported.

Abortion, Spontaneous↗
PubMedDate not supplied

An instrument for measuring endometrial blood flow in the uterus, using two thermistor probes.

An instrument was developed for continuous measurement of thermal conductance reflecting blood flow locally in the endometrium. The probe consists of two small thermistors, one sensing the tissue temperature, and the other working at 5 degrees C elevated temperature, sensing the heat loss caused by thermal conduction mainly due to the blood flow. The power needed to keep this temperature difference was recorded as a measure of flow. When the instrument was tested in model experiments, for measurement of flows at temperatures of 35 to 40 degrees C, stable recordings with high sensitivity were obtained and no influence of the surrounding temperature was observed. Recordings were also made in vivo in non-pregnant women by applying the instrument to the endometrium of the uterine fundus. Intrauterine pressure was recorded simultaneously. The blood flow recordings were stable over long periods in spite of changes in body temperature, but with fluctuations of up to 0.1 mW concomitant with uterine contractions. Pulse-syncronous variations in flow were recorded, indicating a high sensitivity and a short time constant of the instrument. The blood flow effects of vasoactive substances, i.e. vasopressin and a vasopressin antagonist, could readily be distinguished. It is concluded that this instrument can be used for semi-quantitative recordings of blood flow in cavities of the body, for example the uterus, which can be reached by small probes and that changes of body temperature do not effect the measurements.

Biomedical Engineering↗