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Biomedical subjects

P Stubblefield

Publications and source records attributed to P Stubblefield.

5 recordsLinked to original sources
PubMed2000

Low-dose oral contraceptives and bone mineral density: an evidence-based analysis.

We reviewed studies of the association of oral contraceptive (OC) use and bone mineral density (BMD). We limited the review to studies of women using low-dose oral contraceptives and that measured BMD by bone densitometry. A total of 13 studies met the inclusion criteria. Nine of these showed a positive effect of OC use on BMD, and four did not show an association. However, none of the studies showed a decrease in BMD with OC use. We classified the level of evidence from each study according to the guidelines of the US Preventive Services Task Force. The level of evidence supporting a positive association between OC use and increased BMD is II-1. There is fair evidence (Category B) to support the position that OC use has a favorable effect on BMD. We made suggestions for a study design that could yield Level I evidence.

Adult↗
PubMed1998

Single dose methotrexate therapy: application to interstitial ectopic pregnancy.

A woman with a small (6-mm gestational sac) interstitial pregnancy had complete resolution after medical therapy alone. A single cycle of methotrexate 50 mg/m2 was used as outpatient treatment without any operative procedure either for diagnosis or intervention. The guidelines that have evolved for selection of women for single dose methotrexate treatment for both intrauterine and tubal ectopic pregnancies may be applicable to interstitial ectopic pregnancy as well. A suggested framework for treatment decisions is presented.

Adult↗
PubMed1995

Effect of labor analgesia with nalbuphine hydrochloride on fetal response to vibroacoustic stimulation.

OBJECTIVE: To evaluate the effect of labor analgesia with nalbuphine hydrochloride on the fetal response to vibroacoustic stimulation. STUDY DESIGN: The response to fetal acoustic stimulation (FAS) was recorded in 27 laboring patients before analgesia. After analgesia with 5 mg nalbuphine hydrochloride administered subcutaneously, the response to FAS was again recorded. RESULTS: No ominous fetal heart rate (FHR) patterns were observed. FAS reliably increased FHR baseline and long-term FHR variability and produced FHR accelerations. Nalbuphine hydrochloride analgesia did not produce a significant decrease in long-term FHR variability or alter FHR baseline but did reduce the number of FHR accelerations recorded. CONCLUSION: FAS-induced FHR accelerations did not differ from those observed before analgesia. Analgesia with low doses of nalbuphine did not alter fetal response to FAS, which therefore offers a means of assessing fetal well-being even in the narcotized fetus.

Acoustic Stimulation↗
PubMed1992

White blood cell immunization and anticardiolipin antibody levels in women with recurrent miscarriages.

To determine whether WBC immunization stimulates production of anticardiolipin antibodies, anticardiolipin antibodies were measured before and 6 weeks after WBC immunization. Twenty-four non-pregnant women, who had had recurrent miscarriages for which a definitive cause could not be determined, were immunized with their partner's WBC. No significant differences in levels of anticardiolipin antibodies were detected between paired samples of sera obtained before and 6 weeks after WBC immunization. White cell immunization in nonpregnant women did not stimulate production of anticardiolipin antibodies.

Abortion, Habitual↗