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Biomedical subjects

P Suduca

Publications and source records attributed to P Suduca.

At least 19 recordsLinked to original sources
PubMed1994

[Malignant epidermoid tumors of the anus. Etiopathogenesis and clinical aspects].

Malignant squamous tumors of the anus (MSTA) are most often carcinomas of the anus (80 to 85%) but remain rare. They occur above all in women between the age of 45 and 70. Three groups are considered to be high-risk: passive homosexuals, individuals with anal condylomas (in particular HIV+) and women with genital dysplasias or carcinomas. The presentation of MSTA is variable and often quite non-specific: bleeding, pain, pruritus, discharge. Proctological examination reveals an ulcerated lesion, proliferative or infiltrating. The diagnosis is confirmed by biopsy. Clinical (often under general anesthesia) and paraclinical (endoscopy, CT scan and endo-anal ultrasonography) evaluation is necessary. This involves three levels: local (enabling determination of spread in terms of height and circumference and/or infiltration of deep layers), regional (detection of inguinal and/or pelvirectal lymphadenopathy) and general (detection of bone, liver or lung metastases). This evaluation enables classification of the tumor, forming the basis of management choices and defining its prognosis.

Aged↗
PubMed1990

[Treatment of isolated rectal ulcer syndrome].

Our study involved a group of 46 cases of isolated rectal ulcer syndrome. We believed that our management procedure would have to take several factors into consideration. Firstly, the clinical context is of primary importance: the age, psychological context, functional signs and, above all, the state of the lesions. We attached particular importance to distinguishing between the forms of proctitis (whether ulcerated or not) and the pseudotumoral polypoid forms. In addition, complementary explorations (dynamic rectography and anorectal manometry) can provide valuable information (the degree of prolapse, impairment of the exoneration mechanism and the status of sphincter function). In both ulcerated and non-ulcerated forms of proctitis, the treatment is essentially medical and intended to treat the constipation and rehabilitate the exoneration. This treatment suffices in most cases. In poorly tolerated cases, involving persistent bleeding or in forms corresponding to major prolapse, surgery is required which usually includes proctopexy. The first problem posed by pseudotumoral polypoid forms is that of a differential diagnosis to formally exclude cancer or an inflammatory disease process. Transanal biopsy exeresis may be crucial in the diagnosis. In addition, this transanal resection may well initiate therapy, in combination with medication. In some forms, involving major prolapse, it is logical to combine rectopexy. In some cases, rectopexy may be necessary if simple transanal resection is unsuccessful (persistence or recurrence of lesions). Rectopexy is also frequently the only treatment possible of pseudotumoral forms affecting extensive areas or higher regions of the bowel.

Colorectal Surgery↗
PubMed1985

[Anorectal neuralgias].

Ano-rectal neuralgia consists of pain in the ano-rectal region without any underlying organic proctological disease. Classically, three major clinical groups are defined, although associated, successive and intermediary forms may also exist. Proctalgia fugax is the most distinctive condition, consisting of brief episodes of nocturnal pain recurring at very variable intervals. In coccygodynia, the pain is postural and reproduced by pressure and mobilisation of the coccyx. The other forms of ano-rectal pain are grouped under the heading ano-rectal neuralgia or neurosis, which are characterised by the imprecision and the variability of the symptoms described. The pathogenesis of these forms of pain is unknown. Psychiatric elements are generally involved in these conditions, especially in the third clinical group. The treatment suffers from this uncertainty about the pathogenesis. The patient should be reassured by means of the least aggressive proctological procedures.

Anus Diseases↗
PubMed1984

[Inverted polypoid hamartoma of the rectum].

The inverted polypoid hamartoma of the rectum (IPHR) is characterized by polypoid masses composed of ectopic glands of Lieberkühn invaginated within the mucosal muscle to form a conglomeration in the submucosa, hence the term "inverted polyp". It produces an unremarkable rectal syndrome, more suggestive, when abundant glairy exudate is observed, in young subjects. It causes a unique sessile polypoid lesion, occasionally multilobular or a stenotic, approximately circular, ring. Diagnosis is made using deep surgical biopsies. Two theories, dysgenetic or acquired, attempt to explain the pathogenesis of this lesion. The predominant acquired theory includes IPHR in the "solitary rectal ulcer" syndrome which is related to the traumatism of rectal prolapse. Transanal ablation is the predominant treatment.

Adolescent↗
PubMed1977

[Problem posed by the prevention and detection of colorectal cancers].

The incidence of colonic and rectal carcinoma is in constant progression. The detection and destruction of polyps is the only effective means of reducing the number of adenocarcinomas. The technical means of detection are well known and fully proved: rectosigmoidoscopy, thin layer double contrast enema, colonoscopy. The true problem is that of the cost of this prevention. It is important to define high risk groups in which these tests should be carried out as a routine. Furthermore it is necessary to know whether blood tests or examination of the stools may be considered as a means of detection of polyp or at least certain types of potentially malignant polyp. without suggesting a considerable increase in the number of medical investigations, one may hope for better use of sigmoidoscopy and double contrast barium enema. These two examinations represent undoubtedly the essential factor in the diagnosis of colonic and rectal tumours.

Adenocarcinoma↗
PubMed1976

[Clinical aspects and course of drug-induced upper digestive hemorrhage].

In a series of 500 patients admitted to hospital for upper digestive hemorrhage, the authors studied the influence of taking drugs on the clinical characteristics and course of the original disease. Taking aspirin is exceptional before rupture of esophageal varices. One may isolate a homogenous group of elderly women consuming aspirin and another anti-inflammatory drug, and bleeding from a gastric ulcer. One may also isolate another group of men, bleeding from acute gastro-duodenal lesions after taking aspirin alone. If one considers apart portal hypertension, owing to its extreme gravity, one may note that the prognosis depends on the age. One patient out of five, dies of hemorrhage after the age of 60 years. Taking an anti-inflammatory drug at this age is thus not harmless.

Adrenal Cortex Hormones↗
PubMed1976

[Cholestatic hepatitis with a chronic course. 7 cases].

Cholestatic hepatitis, whilst having a longer course than cytolytic forms, in general regresses in a few months. The authors report here seven cases of cholestatic hepatitis lasting for more than 18 months. These chronic forms have certain characteristic features: - female predominance (6 cases out of 7). - a severe degree of cholestasis with, in particular, marked elevation of lipids, cholesterol and alkaline phosphatase. - the absence of Australia antibody and antigen, together with the absence of anti-smooth muscle antibody and anti-mitochondrial natibody. - a decrease in the number of permeable biliary canaliculi in the portal spaces. - a decrease in the number of permeable biliary canaliculi in the portal spaces. - a course which appears to be little influenced by various therapeutic measures. Although the final course seems satisfactory on the majority of cases, the possibility of a slow cirrhogenic transformation cannot be excluded in certain instances.

Adult↗