Use of atracurium in the presence of lower or upper limb tourniquets.
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Biomedical subjects
Publications and source records attributed to P Suppan.
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The authors have tried "priming" the cervix by the administration of a single extraamniotic dose of a F2-alpha prostaglandin gel. This is shown to decrease the risks of trauma associated, with the often difficult, instrumental dilatation of a primigravid cervix at the time of the termination of a 9-12 week pregnancy. The dilatation observed at curettage after this single dose was on the average 10.5 mm +/- 2.2 mm. This is very significantly (p < 0,0001) different from that of patients who received a placebo gel, in which the average diameter of the cervical canal was 4.5 mm +/- 1.0 mm. Constituting a sure and safe method this single priming dose is only applicable when the pain, from the uterine contractions that it produces, can be controlled in an efficient manner. The comparisons made concerning this point, in this paper, show that it can only be done by the use of a continuous epidural anaesthetic. This obviates the necessity of another anaesthetic at the time of aspiration-curettage.
The increased rate of glycolysis in neoplastic cells may be used to design tentatively antimetabolites whose detoxification would be faster in normal cells. Pyruvo-substituted nucleotides are examined in this respect and their expected differential metabolism outlined.
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A technique of indirect determination of arterial systolic pressure using a photoelectric pulse monitor signal to indicate arterial occlusion has been applied to the feed-back control of halothane administration. In normotensive patients, the inspired halothane concentration had little influence on arterial pressure; in about 25% of patients a periodic pattern between the low and medium outputs of the vaporizer occurred. In hypertensive patients, the arterial pressure was more sensitive to the depressant effects of halothane and the concentration administered was reduced automatically as the operation proceeded.
Pancuronium and a continuous infusion of althesin was used to produce muscular relaxation in a patient with myotonic dystrophy. Excellent muscle relaxation with absence of percussion or surgically induced myotonia was obtained but the EMG was not modified; an intracellular site of action of althesin is postulated. Cardiovascular stability was remarkable peroperatively; post-operatively an increased myocardial susceptibility to hypokalaemia was noticed.
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A case is reported in which obstetric management resulted in 52 minutes elapsing between the induction of anaesthesia and delivery by Caesarean section. The mother was induced and maintained on Althesin and minimal methoxyflurane throughout this period without detriment to the neonate.