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P Sussman

Publications and source records attributed to P Sussman.

7 recordsLinked to original sources
PubMed1984

Quantitative description of sleep stage electrophysiology using digital period analytic techniques.

The purpose of the current study was to assess the overlap in variance of two procedures for the quantification of sleep electrophysiology: conventional stage scoring and computer quantification of tonic activity. Data were collected on 24 nights from eight subjects and were scored according to a modified set of Rechtschaffen and Kales criteria and submitted to a period-analytic computer analysis. Following this, discriminant function analyses were performed on the data for each night to predict the visual stage scores from the computer-generated data. The results indicate a very high degree of predictive accuracy (91.05%) supporting the contention that the computer-quantified data set includes the variance normally captured by stage scoring. The implications of computer quantification of sleep electrophysiology are discussed.

Adolescent↗
PubMed1979

The description of structural and temporal characteristics of tonic electrophysiological activity during sleep.

The structural and temporal characteristics of tonic variation among electrophysiological measures during sleep are examined from the point of view of sleep stage scoring procedures and the digital quantification and statistical analysis of these measures. Sleep stage scoring procedures are nominally scaled and therefore less able to index structural and temporal characteristics than are measures derived from digital methods of quantification having the properties of interval or ratio scales. These arguments are illustrated using principal components analysis to describe the structure of tonic covariation among 36 variables derived from the computer analysis of EEG, EMG, and EOG. Three components resulting from the analysis are tentatively named 'slow-fast', 'hemispheric-shift' and 'eyes-activation'. They appear across variations in experimental manipulations such as night time awakenings and also across differences in age and species. The periodic characteristics of the vectors associated with the three components are specified by means of the Fast Fourier transform in combination with digital low pass and band pass filtering. Cycles are found which are both slower and faster than the paradigmatic 90 min ultradian rhythm. These results indicate that currently available techniques of digital and statistical analysis provide new possibilities for research on the electrophysiology and psychophysiology of sleep.

Adolescent↗
PubMed1975

Naproxen in rheumatoid arthritis. A controlled trial.

The efficacy of naproxen in treating rheumatoid arthritis patients was evaluated in a double-blind clinical trial using aspirin as the control drug. The study was conducted at seven centers and involved 80 patients. After an unequivocal increase in disease activity during a drug-free period, patients were randomly assigned to either drug and continued in the trial for 16 weeks. Some patients took low maintenance doses of corticosteroids, or gold salts, or both throughout the trial. Both test drugs significantly decreased disease activity as measured by a number of ways. By objective measurements, naproxen was as effective as aspirin, although patients in the naproxen-treated group entered the trial with more severe disease. By some subjective evaluations, naproxen was considered more effective than aspirin. Although patients taking naproxen had less frequent gastrointestinal side effects and fewer symptoms VIIIth nerve toxicity, the differences were not statistically significant. We conclude that naproxen is a useful addition to the physician's armamentarium for the treatment of rheumatoid arthritis.

Adrenal Cortex Hormones↗