PubMed Health⌕ Search

Biomedical subjects

P Szerze

Publications and source records attributed to P Szerze.

14 recordsLinked to original sources
PubMed1980

Iodine metabolism and iodothyronine (T3 and T4) binding in human polymorphonuclear leucocytes in vitro.

Surviving human polymorphonuclear leucocytes (PMNL) were found to incorporate and metabolize 125I in vitro. After incubation the metabolized iodine may be found in three different fractions which may be separated by Sephadex G-200 column chromatography. The first fraction consists of deoxyribonucleoproteins and specifically binds T3 (Bmax) 4 x 10(-12) mol mg-1 protein; Ka (4.5 x 10(11) mol-1 mg) and T4 (Bmax) 13 x 10(-12) mol mg-1 protein; Ka (0.77 x 10(11) mol-1 mg). The second fraction binds iodine and T4 by a non displaceable manner. It appears to be acid precipitable and possibly of iodoprotein nature. The third fraction of iodinated molecules was further analyzed with the aid of Sephadex G-10 column chromatography and it was found that these compounds may correspond to iodothyronines, as concluded from their physicochemical characters. The addition of T3 or T4 or TSH reduced the radioactivity associated presumably to nucleoproteins and iodoproteins. These experiments suggest a possibility of intracellular synthesis and macromolecular binding of iodothyronine-like compounds in PMNL and the influence of external T3, T4 and TSH.

Female↗
PubMed1978

Stimulation of phagocytosis by human lymphokines.

Supernatants of concanavalin A stimulated human lymphocytes increased the phagocyting and intracellular killing activities of human macrophages and neutrophils tested with particles of Saccharomyces cerevisiae.

Humans↗
PubMed1977

Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages.

The ability of human polymorphonuclear granulocytes and alveolar macrophages from rats to ingest Saccharomyces cerevisiae was tested in vitro in the presence of various concentrations of emetine and libexine. Emetine 4.0 and 40.0 microgram/ml caused an increase in the phagocytic index of polymorphonuclear granulocytes and alveolar macrophages. After oral administration of emetine the phagocytosis-enhancing effect was still apparent. Intracellular killing was not influenced by emetine or libexine.

Adult↗
PubMed1977

Antibody-dependent cell-mediated cytotoxicity in Graves disease.

The antibody-dependent cell-mediated cytotoxicity of peripheral lymphocytes from patients with Graves disease was tested using chicken erythrocytes coated with rabbit antichicken red blood cell antibody and labelled with 51Cr. An increased cytotoxic activity was found in untreated Graves disease without ophthalmopathy. The cytotoxic activity was less elevated in the groups of patients with severe ophthalmopathy or high level of anti-thyroglobulin antibody, and approximately normal after methimazole treatment.

Adolescent↗
PubMed1976

Inhibition of spontaneous E-rosetting by antithymocyte globulin in Graves disease.

The number of thymus-dependent (T) lymphocytes and the concentrations of antithymocyte-globulin causing 25% inhibition of E-rosetting were determined in 40 cases of Graves disease. No significant difference in T-lymphocyte count was found between the test groups and the control group. An increased resistance of T-lymphocytes to antithymocyte globulin was found in Graves disease, particularly in its form marked by progressive ophthalmopathy. The increase in resistance was significant in the first five years of the disease.

Adolescent↗
PubMed1975

Examination of HL-A antigens and lymphocytotoxic antibodies in discoid lupus erythematosus.

The distribution of HL-A antigens and lymphocytotoxic antibodies has been studied in the sera of patients suffering from discoid lupus erythematosus (DLE). A significant deviation in HL-A5 antigen has been found in the 33 cases investigated, while the lymphocytotoxic antibodies were present in only 8 sera. The possible cause of these findings are discussed.

Antibodies↗
PubMedDate not supplied

Investigation of the chemiluminescence associated with phagocytic and intracellular killing activity of human polymorphonuclear leucocytes and monocytes.

The chemiluminescence associated with phagocytic and intracellular killing activity of human polymorphonuclear leucocytes and monocytes was investigated. A significant, opsonization-dependent increase in photon emission of polymorphonuclear leucocytes and monocytes was observed induced by engulfment of opsonized, heat-killed and living fungi (Saccharomyces cerevisiae), aggregated gamma globulin, latex and India ink particles. Mononuclear cells displayed only minimal enhancement of photon emission after incubation of various particles. It is suggested that the method can be used in clinical practice as a test of phagocytotic and intracellular killing function.

Adolescent↗