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Biomedical subjects

P T Doyle

Publications and source records attributed to P T Doyle.

At least 37 records · Page 2Linked to original sources
PubMed1988

The investigation of painless haematuria--a comparison of intravenous urography and DMSA scintigraphy.

In order to test in a prospective study the suggestion that there should be a shift from the intravenous urogram to DMSA scintigraphy for the diagnosis of suspected renal masses, both investigations were performed in 63 patients with painless haematuria. While the sensitivity of both investigations was similar in renal lesions, specificity was slightly less for scintigraphy. These findings, together with the intrinsic limitations of the DMSA scintigram in detecting lesions elsewhere in the urinary tract, lead us to conclude that the intravenous urogram should remain the initial investigation for painless haematuria unless there are specific contraindications.

Hematuria↗
PubMed1988

Serial residual volumes in men with prostatic hypertrophy.

Thirty men with prostatic hypertrophy were scanned on 3 occasions on the day before TURP. Five commonly used formulae to estimate residual urine were used. All of these methods are subject to large degrees of error; 66% of these patients had residual volumes that varied significantly on the same day. We suggest that it is of no clinical value to perform a single residual urine measurement in patients with prostatic hypertrophy.

Aged↗
PubMed1988

The use of endoscopic detrusor muscle biopsies for in vitro muscle strip studies.

A technique is described for performing in vitro muscle strip studies using samples of detrusor muscle taken by means of endoscopic biopsy forceps. This study of pig bladder muscle showed that the nerve mediated and drug induced responses of the muscle showed that the nerve mediated and drug induced responses of the muscle biopsies were similar to those produced by traditionally dissected muscle strips. The importance of continued access to human material for pharmacological studies is discussed.

Acetylcholine↗
PubMed1988

Internal iliac artery embolisation for the control of severe bladder and prostate haemorrhage.

Embolisation of the internal iliac artery was preformed under local anaesthesia in eight patients with severe bladder haemorrhage and in two with severe bleeding from the prostatic bed after prostatectomy. Good and effective control of the bleeding was achieved in six of the patients with bladder haemorrhage, with a partial response in the other two. Both patients with post-prostatectomy bleeding responded well to embolisation, with prompt cessation of the bleeding. This technique is recommended for the control of severe bleeding from the bladder or prostate in the seriously ill patient.

Aged↗
PubMed1987

Improving splintage techniques in pyeloplasty.

One hundred patients undergoing pyeloplasty were studied and the outcome assessed with particular reference to the splintage technique used. A double J stent was used in 16 patients instead of a more traditional external drainage technique. The use of the double J stent for splintage of a pyeloplasty anastomosis was associated with a marked reduction in hospital stay and with fewer post-operative complications when compared with external drainage techniques. The double J stent is recommended in cases where a pyeloplasty anastomosis is to be splinted.

Adolescent↗
PubMed1987

Bladder instability and denervation in patients with bladder outflow obstruction.

In vitro pharmacological studies were performed on endoscopic detrusor biopsies from patients with bladder outflow obstruction. Urodynamic studies had been undertaken to detect the presence of bladder instability. Muscle strips from patients with instability demonstrated supersensitivity to acetylcholine and reduction in nerve mediated responses, as compared with strips from stable bladders. These changes are interpreted as suggesting the presence of cholinergic denervation in obstructed patients with bladder instability.

Acetylcholine↗
PubMed1986

Role of computed tomography in assessing "operability" of bronchial carcinoma.

To try to assess the accuracy of predicting "operability" (as defined by local policy) of bronchial carcinoma 300 patients underwent computed tomography of the thorax in a prospective study. The results of 141 patients showed an agreement between computed tomographic and surgical (including pathological) findings in those patients who had received operations. Most of the other patients had more advanced disease than suggested by the findings of computed tomography. A total of 118 patients did not receive operations: in 47 their disease was considered to be inoperable on the basis of computed tomographic findings alone, and this was accepted by the cardiothoracic surgeons after consultation. Thirty two other patients had further evidence of metastatic disease on other investigations. Computed tomography of the thorax should be performed early in the assessment of operability of patients with bronchial carcinoma and before the start of an extensive search for metastatic disease.

Carcinoma, Bronchogenic↗
PubMed1982

The prediction of invasive potential in superficial transitional cell carcinoma of the bladder.

A and B blood group specific monoclonal antibodies have been used in an indirect immunoperoxidase technique to detect blood group isoantigen (BGI) on normal transitional epithelium and its possible loss on malignant cells. On all 14 specimens of normal tissue and on 31 of 39 (79%) superficial transitional cell carcinomas of the bladder BGI was detected. The incidence of invasive recurrence in the BGI-negative group (50%) was significantly higher than in the BGI-positive group (13%). It is concluded that this method of detecting BGI expression offers several advantages over existing techniques and identifies a group of patients with superficial transitional cell carcinomas of the bladder who are at higher risk of developing an invasive recurrence.

ABO Blood-Group System↗
PubMed1981

Sensory level and renal prognosis in myelomeningocele.

Two hundred and fourteen cases of spinal dysraphism were studied to investigate the relationship of sensory level and renal damage. It was found that in 72 cases with a high sensory level of T12 and above, 45 cases (62%) had renal damage which was the cause of death in 12; in 142 cases with a low sensory level of L1 and below, 40 cases (28%) had renal damage which was the cause of death in only 2. A palpable bladder and reflux were associated with renal damage in the cases with a low sensory level but some additional factor appears to operate in those with a high sensory level. Other reasons for the poor prognosis in these cases are discussed. The critical level in the spinal cord at which the prognosis for renal damage sharply changes coincides with the sympathetic outflow to the renal tract (T12-L1). Disruption of the spinal cord at or above the renal outflow may be a determining factor in prognosis.

Adolescent↗