PubMed Health⌕ Search

Biomedical subjects

P Tarjan

Publications and source records attributed to P Tarjan.

14 recordsLinked to original sources
PubMed2000

Antiprothrombin and antiannexin V antibodies imply risk of thrombosis in patients with systemic autoimmune diseases.

OBJECTIVE: To investigate the relationship between antiprothrombin (aPT) and antiannexin V (aANX) autoantibodies of IgG isotype and thrombosis in patients with systemic autoimmune diseases. To compare the clinical relevance of these antibodies to that of anticardiolipin (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), and lupus anticoagulant (LAC). METHODS: Serum IgG aPT, aANX, aCL, and anti-beta2-GPI levels were measured by solid phase enzyme immunoassay in the sera of 70 patients with systemic autoimmune diseases, 35 with antiphospholipid syndrome (APS) and 35 without APS. Medical records were analyzed, and associations of the antibodies with clinical features of APS were assessed. RESULTS: Patients with APS had higher frequency of aPT (p = 0.001) and aANX (p = 0.002) compared to patients without APS. Thrombotic events occurred more frequently in those with aPT or aANX than those without (p = 0.005, p = 0.006, respectively). The presence of aPT and aANX was found to be highly specific for APS. CONCLUSION: Measurement of aPT and aANX antibodies may be of value in confirming the diagnosis of APS, and in evaluating risk of venous and arterial thrombosis in patients with systemic autoimmune diseases.

Adult↗
PubMed1986

An experimental device for low-energy, precise ablation of AV conduction.

A combination suction catheter-bipolar lead system permits precise ablation of AV conduction with low energy. The electrode is positioned to maximize the bipolar His potential, then to maximize the HP between the tip and a surface electrode. With the tip held in place by 100-200 mmHg of suction, this site is paced. If the St-V interval is short and the ventricular morphology is similar to a sinus beat, a shock of 10 or 20 J is delivered. If complete heart block does not result, additional shocks are delivered. The device was used in eight dogs. When the St-V was close to the unpaced H-V interval, a shock of 20 J always produced permanent CHB. In contrast, an initial shock of 10 J always failed, and more shocks of up to 30 J were required to produce CHB which, even then, did not always persist. At 60 days the hearts were healed with a round, white, dense scar of about 2 mm in diameter just above the leaflet of the tricuspid valve. This device can produce permanent dissociation of the atria and ventricles with a shock of 20 J. It also enables precise positioning of the electrode.

Animals↗
PubMed1984

Redundant pacing: case report and review.

A 17-year-old boy with severe sick sinus bradycardia had a doubly redundant pacemaker inserted. With two separate ventricular leads inserted by the epicardial route, the pacemaker is able to compensate for a lead that has developed high threshold by activation of an alternate lead. The two pacing channels of the pulse generator can be programmed independently of one another. In addition, there is a back-up pacing circuit separate from the two primary channels. The pacer can be used with both channels active for continuous automatic redundancy for safety, or with one channel active and the other in reserve.

Adolescent↗