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Biomedical subjects

P Tewari

Publications and source records attributed to P Tewari.

At least 19 recordsLinked to original sources
PubMed2006

Emergency cardiopulmonary bypass for impassable airway.

INTRODUCTION: Some medical emergencies need compromised airway management as the first measure. Most of these cases are first seen by an ENT surgeon, whose proper evaluation and timely intervention can prove decisive. Knowledge of alternatives for airway management can prove life-saving, although these may require the active involvement of other specialities. CASE REPORTS: Two patients, a 27-year-old man and a 31-year-old woman, presented in respiratory distress with cyanosis. Each had a pedunculated mass in the lower trachea above the carina, with about 90 per cent tracheal lumen obstruction. They were managed successfully with femorofemoral cardiopulmonary bypass and restoration of airway. CONCLUSION: Femorofemoral cardiopulmonary bypass can be a relatively safe option which gains time for airway management in such conditions. Knowledge of this procedure among ENT surgeons can lead to timely intervention, in properly selected cases, which can save valuable time.

Adult↗
PubMed2006

Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.

A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.

Animals↗
PubMed2003

An unusual case of neonatal anuria.

Neonatal anuria is not an uncommon problem in neonates. Here, we report an unusual case of neonatal anuria due to renal tubular dysgenesis, secondary to the use of angiotensin converting enzyme inhibitor (ACEI) during pregnancy. ACEI remains one of the most commonly used antihypertensive drug at present. A greater awareness needs to be created in the medical fraternity especially among pediatricians, gynecologists and internists that ACE inhibitors should not be prescribed during any trimester of pregnancy.

Adult↗
PubMed1996

Combined left-sided recurrent laryngeal and phrenic nerve palsy after coronary artery operation.

BACKGROUND: Ice/saline slush used along with cold cardioplegia for heart arrest in cardiac operations can cause hypothermic damage to certain structures, an important one being the left phrenic nerve, damage of which results in raised left hemidiaphragm and delayed recovery of the patient. In coronary artery bypass grafting, opening of the pleura and collection of the ice/saline slush in the pleural cavity increases the incidence of injury. METHODS: Three of our nonconsecutive patients underwent coronary artery bypass grafting with cold cardioplegia and open pleura, with collection of ice/saline slush in the pleural cavity for a sufficiently long time. RESULTS: Simultaneous involvement of left recurrent laryngeal nerve along with left phrenic nerve was found in all patients without any concurrent topical injury around the larynx. the recurrent laryngeal nerve took 8 to 10 months to recover. CONCLUSIONS: The left recurrent nerve as it arches around aorta lies in the thorax very close to the parietal pleura and may be prone to hypothermic injury by ice/slush collecting in the pleural cavity during cardiac operations. Judicious use of ice/saline slush had helped in eliminating the problem to some extent.

Aged↗
PubMed1995

Hypertension and tachycardia during adrenal manipulation.

The purpose of this report is to draw attention to haemodynamic changes during intraoperative adrenal gland manipulation. Severe hypertension, ventricular tachycardia and subendocardial ischaemia occurred during the manipulation of adrenal gland in a patient who underwent live related donor nephrectomy. The patient responded well to intravenous lidocaine. Plasma norepinephrine concentration was elevated at the time of event. Further investigations after surgery excluded the possibility of phaeochromocytoma. In two years follow-up patient remains well. Suspicion for the cause of the event remains the excessive release of catecholamines with manipulation of a normal adrenal gland. The presence of halothane might have contributed to the arrythmia.

Adrenal Glands↗
PubMed1994

Resuscitation after modified Fontan procedure.

As the survival rate after modified Fontan procedure is increasing, cardiopulmonary resuscitation may be needed in such patients for other causes not related to their cardiac status. The state-of-the-art cardiopulmonary resuscitation with external chest compression may not be sufficient to revive such patients, and the addition of external abdominal compressions may help in the final outcome, as is reported here.

Abnormalities, Multiple↗
PubMed1987

A simple test to monitor aromatic amine clearance in occupational workers.

A simple, quick and sensitive procedure is described to monitor urinary clearance of aromatic amines in industrial workers. Estimation is based on the measurement of coloured Schiff's bases developed with 4-dimethylaminocinnamaldehyde-organic acid reagent. Extraction of amines in water saturated butanol ensured 89-97% recovery from biological samples with a coefficient of variation of less than 8%. Regression analyses of the absorbance-concentration curves with different aromatic amines showed excellent correlation coefficient and a high molar absorptivity with the lowest detection limits ranging between 0.05-0.12 microgram ml-1. The proposed reagent has additional use as a spray reagent to detect amine spots on chromatograms. Low final acidity ensures estimates of free amines without causing hydrolysis of conjugated amines.

Amines↗