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Biomedical subjects

P Timon-David

Publications and source records attributed to P Timon-David.

At least 37 records · Page 2Linked to original sources
PubMed1991

Evaluation of in-vitro leishmanicidal activity of hydrazones of thiophene carboxaldehydes against promastigotes of Leishmania infantum and Leishmania tropica.

The lack of leishmanicidal drugs has prompted the synthesis and testing of new hydrazones of thiophene carboxaldehydes against three Leishmania strains. The compounds were obtained by condensation of appropriate hydrazines with thiophene 2-carboxaldehyde (series 1), thiophene 3-carboxaldehyde (series 2), and 5-nitrothiophene-2-carboxaldehyde (series 3). Leishmanicidal activity was assessed against promastigotes of Leishmania strains, grown in-vitro in nutrient broth medium complemented with fresh rabbit blood. The minimal inhibitory concentrations were evaluated against pentamidine, as a reference drug. Several compounds exhibited significant leishmanicidal activity, the best being ten times more active than pentamidine.

Animals↗
PubMed1987

In vitro chemosensitivity of Plasmodium falciparum to four chloroquine derivatives.

The antimalarial activity of four chloroquine derivatives has been assessed in vitro by the Trager and Jensen technique against the strain of Plasmodium falciparum FCC, 2spp. Monodesethyl-chloroquine possessed a significant activity, reducing the parasitaemia to 5% with 2 nM ml-1 (base). The hydroxy-metabolite showed a slight activity, reducing the parasitaemia to 39.5% with 2 nM ml-1 (base). No activity was found with the amino-metabolite and the pyrrolidinyl chemical derivative. The anti-malarial activity of monodesethyl-chloroquine should be considered for pharmacokinetics and for optimizing chloroquine treatments.

Animals↗
PubMed1987

Anthelmintic properties of Polygonum glabrum.

A pure anthelmintic substance (PGA) has been isolated from the methanol-aqueous extract of the leaf of Polygonum glabrum Willd., a semi-aquatic Sudanese species of the family Polygonaceae. The antiparasitic in-vitro activity of several fractions isolated from the plant, has been examined comparatively with that of PGA. PGA also showed molluscicidal activity against Biomphalaria glabrata and Limnea truncatula Müll. Structural determination of PGA was attempted following data analysis of UV, IR, 13C NMR, 1H NMR and MS spectra and suggests that PGA is a terpenoid.

Animals↗
PubMed1986

[Intravector anti-Plasmodium activity of a pyrethrinoid: deltamethrin].

In vitro tests, deltamethrin reduced the parasitemic index of Plasmodium falciparum on human red blood corpuscles. In vivo tests, at sublethal doses, deltamethrin limited the development of the sporogonic cycle of Plasmodium yoelii yoelii in Anopheles stephensi. This novel type of antiplasmodic activity involve an intravectorial route and gives an explanation about surprising antimalaria effects observed several months after treatment.

Animals↗
PubMed1985

[Effect of invertebrate rickettsiae on vertebrates: experimental infection of mice by Rickettsiella grylli].

An analysis by cytology, electron microscopy, and serology of experimental infections of the mouse by an invertebrate rickettsia with chlamydial cycle, Rickettsiella grylli, showed that, according to the routes and the severity of the infection, the pathogen can have no effect, or cause local inflammations, or induce degenerative or malignant processes. The very limited development of the pathogen as well as the possible direct role of the chlamydial elementary bodies and toxins in the pathogenesis are discussed.

Animals↗
PubMed1982

[Comparative study of fungicidal activity in vitro of various quaternary ammonium compounds used in ophthalmology].

A study was conducted to evaluate the antifungal activity in vitro of 5 quaternary ammonium compounds. N cetylpyridinium was found to be particularly active against Candida albicans and Aspergillus fumigatus. The association of N cetylpyridinium and of neosynephrine, found in various eye drop compositions, resulted in potentation of the antifungal activity of this quaternary ammonium.

Antifungal Agents↗